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Interleukin-12

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Cola

Direct intratumoral injection of metastatic hepatic tumors using an adenoviral vector expressing the human recombinant interleukin-12 gene

adenovirus vector

interleukin-12 gene

Max W. Sung, MD

RATIONALE: Inserting the interleukin-12 gene into a person's cancer cells may make the body build an immune response to kill tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of interleukin-12 gene when injected into the tumors of patients with liver metastases secondary to colorectal cancer.

OBJECTIVES:

* Determine the toxicity and maximum tolerated dose of intratumoral adenoviral vector-delivered interleukin-12 gene in patients with liver metastases secondary to colorectal cancer .
* Determine the tumor response in patients treated with this regimen.
* Determine the immune response in patients treated with this regimen.

Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal Cancer

Phase I Trial Of Adenoviral Vector Delivery Of The Human Interleukin-12 cDNA By Intratumoral Injection In Patients With Metastatic Colorectal Cancer To The Liver

toxicity will assessed from grades 0 to 4 as per common toxicity criteria

tumor masses enumerated and measured pre-treatment and 4 weeks after treatment and changes in the tumor calculated.

National Cancer Institute (NCI)

Max Sung

Associate Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal Cancer	NCT00072098	Colorectal Canc... Metastatic Canc...	adenovirus vect... interleukin-12 ...	18 Years -	Icahn School of Medicine at Mount Sinai
Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal Cancer	NCT00072098	Colorectal Canc... Metastatic Canc...	adenovirus vect... interleukin-12 ...	18 Years -	Icahn School of Medicine at Mount Sinai

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