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Lactitol

Adjuvanted influenza A(H1N1) vaccines

The objective of this study is to assess vaccine responses to novel adjuvanted influenza A(H1N1) vaccines in patients at high risks of influenza A(H1N1) complications.

This prospective, open-label, parallel-cohorts study will include up to 1250 patients and 250 controls to whom influenza A(H1N1) immunization was recommended.

Six cohort have been established, enrolling patients with HIV infection, rheumatic diseases, organ transplant, cancer, pediatric patients and healthy controls.

Subjects will be assessed for specific antibody responses (all), T cell responses (subset) and solicited vaccine adverse events. Vaccine safety evaluation will include the influence of immunization on underlying diseases (HIV infected patients, patients with auto-immune diseases) or graft function (transplant patients) - as appropriate.

Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients

Prospective Cohort Study of the Influence of Age, Underlying Disease and Immunosuppression on Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients.

University Hospital, Geneva

Prof. Claire-Anne Siegrist

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients	NCT01022905	HIV Infection Rheumatic Disea... Cancer Transplant Pediatrics	Adjuvanted infl...	6 Months -	University Hospital, Geneva
Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients	NCT01022905	HIV Infection Rheumatic Disea... Cancer Transplant Pediatrics	Adjuvanted infl...	6 Months -	University Hospital, Geneva

Spots Global Cancer Trial Database for adjuvanted influenza a(h1n1) vaccines