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Spots Global Cancer Trial Database for adoptive cell therapy

Every month we try and update this database with for adoptive cell therapy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study titleNCT IDConditionsInterventionsEligibilityOrganizationLink
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular MelanomaNCT01814046
Metastatic Ocul...
Metastatic Uvea...
Aldesleukin
Cyclophosphamid...
Fludarabine
Young Tumor Inf...
16 Years - 75 YearsNational Institutes of Health Clinical Center (CC)
Novel BCMA-targeted CAR-T Cell Therapy for Multiple MyelomaNCT04706936
Relapsed or Ref...
anti-BCMA CAR-T
Cyclophosphamid
Fludarabine
18 Years - 75 YearsSecond Affiliated Hospital, School of Medicine, Zhejiang University
A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid TumorsNCT03970382
Solid Tumor
NeoTCR-P1 adopt...
nivolumab
IL-2
18 Years - PACT Pharma, Inc.
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast CancerNCT06121557
Breast Neoplasm...
Surgery for har...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Camrelizumab
Chemotherapeuti...
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Harvesting Cells for Experimental Cancer TreatmentsNCT00068003
Melanoma
Gastrointestina...
Metastatic Canc...
Breast Cancer
Non-Small Cell ...
Anti-CD19 CAR P...
18 Years - National Institutes of Health Clinical Center (CC)
CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic CancerNCT01218867
Metastatic Canc...
Metastatic Mela...
Renal Cancer
Anti-VEGFR2 CAR...
Cyclophosphamid...
Aldesleukin
Fludarabine
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Chemotherapy, Irradiation, Cell Infusions, and Interleukin-2 to Treat Metastatic MelanomaNCT00314106
Metastatic Mela...
Melanoma Reacti...
Cyclophosphamid...
IL-2
Fludarabine
1200 total body...
18 Years - National Institutes of Health Clinical Center (CC)
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated CancersNCT05686226
Cervical Cancer
Throat Cancer
Oropharynx Canc...
Anal Cancer
Vulva Cancer
Vaginal Cancer
Penile Cancer
Metastatic Canc...
HPV-Related Mal...
HPV-Related Car...
HPV-Related Cer...
HPV-Related Squ...
HPV-Related Ade...
HPV Positive Or...
HPV-Associated ...
HPV-Related Ade...
HPV-Related End...
HPV-Related Ana...
HPV-Related Pen...
HPV-Related Vul...
HPV Positive Re...
E7 TCR-T cells
18 Years - Rutgers, The State University of New Jersey
CRTE7A2-01 TCR-T Cells for HPV-16 Positive Advanced CancersNCT06358053
Cervical Cancer
Anal Cancer
Head and Neck C...
Other Solid Tum...
CRTE7A2-01 TCR-...
18 Years - 65 YearsCorregene Biotechnology Co., Ltd
Assessment of the Safety and Tolerability of ex Vivo Next-generation Neoantigen-selected Tumor-infiltrating Lymphocyte (TIL) Therapy in Advanced Epithelial Tumors and Immune Checkpoint Blockade (ICB) Resistant Solid TumorsNCT05141474
Epithelial Tumo...
Malignant Solid...
NEXTGEN-TIL
Non-myeloablati...
Interleukin-2
18 Years - Vall d'Hebron Institute of Oncology
Chemotherapy Followed by Infusion of DMF5 Cells to Treat Metastatic MelanomaNCT00924001
Melanoma
Malignant Melan...
Melanoma, Exper...
DMF5 Melanoma R...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - National Institutes of Health Clinical Center (CC)
Expanded Access Program of Lifileucel (LN-144) in Patients With Unresectable or Metastatic MelanomaNCT05398640
Unresectable Me...
Metastatic Mela...
Lifileucel
18 Years - Iovance Biotherapeutics, Inc.
Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLCNCT04069936
Non Small Cell ...
Lung Cancer
Lung Cancer Met...
Lung Cancer, No...
Non Small Cell ...
NSCLC
Non-small Cell ...
Non-small Cell ...
MILs™ - NSCLC
nivolumab
tadalafil
18 Years - WindMIL Therapeutics
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast CancerNCT06121570
Breast Neoplasm...
Sentinel Lymph ...
Doxorubicin
Epirubicin
Cyclophosphamid...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Nab-paclitaxel
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney CancerNCT00328861
Metastatic Mela...
Metastatic Kidn...
Natural Killer ...
IL-2
Cyclophosphamid...
Fludarabine
18 Years - National Institutes of Health Clinical Center (CC)
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular MelanomaNCT01814046
Metastatic Ocul...
Metastatic Uvea...
Aldesleukin
Cyclophosphamid...
Fludarabine
Young Tumor Inf...
16 Years - 75 YearsNational Institutes of Health Clinical Center (CC)
Vemurafenib and White Blood Cell Therapy for Advanced MelanomaNCT01585415
Metastatic Canc...
Melanoma
Vemurafenib
Young TIL
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - 66 YearsNational Institutes of Health Clinical Center (CC)
BATs in Patients With Breast Cancer and Leptomeningeal MetastasesNCT03661424
Breast Cancer F...
Leptomeningeal ...
HER2 BATs
18 Years - University of Virginia
Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue SarcomaNCT04052334
Sarcoma
TIL
Interleukin-2
Fludarabine
Cyclophosphamid...
18 Years - 39 YearsH. Lee Moffitt Cancer Center and Research Institute
BATs Treatment for Pancreatic Cancer, Phase Ib/IINCT03269526
Locally Advance...
Metastatic Panc...
EGFR BATs after...
18 Years - University of Virginia
Harvesting Cells for Experimental Cancer TreatmentsNCT00068003
Melanoma
Gastrointestina...
Metastatic Canc...
Breast Cancer
Non-Small Cell ...
Anti-CD19 CAR P...
18 Years - National Institutes of Health Clinical Center (CC)
Novel BCMA-targeted CAR-T Cell Therapy for Multiple MyelomaNCT04706936
Relapsed or Ref...
anti-BCMA CAR-T
Cyclophosphamid
Fludarabine
18 Years - 75 YearsSecond Affiliated Hospital, School of Medicine, Zhejiang University
Chemotherapy Followed by Infusion of DMF5 Cells to Treat Metastatic MelanomaNCT00924001
Melanoma
Malignant Melan...
Melanoma, Exper...
DMF5 Melanoma R...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - National Institutes of Health Clinical Center (CC)
To Evaluate the Safety and Efficacy of ADP-TILIL7 in Patients With Locally Advanced or Metastatic MelanomaNCT06204991
Melanoma Stage ...
Melanoma Stage ...
Melanoma
ADP-TILIL7
Cyclophosphamid...
Fludarabine Pho...
Proleukin
18 Years - 75 YearsHerlev Hospital
Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal CancerNCT02948426
Fallopian Tube ...
Ovarian Cancer
Primary Periton...
Autologous Mono...
18 Years - National Institutes of Health Clinical Center (CC)
Adoptive Cell Therapy Across Cancer DiagnosesNCT03296137
Cancer
Autologous tumo...
Ipilimumab
Nivolumab
proleukin
Cyclophosphamid...
Fludara
18 Years - 70 YearsHerlev Hospital
A First-In-Human Trial of pTTL in Advanced Colorectal CancerNCT05908643
Colorectal Canc...
pTTL
18 Years - Neogap Therapeutics AB
Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic MelanomaNCT01005745
Metastatic Mela...
Surgery
Administration ...
Adoptive Cell T...
High Dose IL-2
18 Years - H. Lee Moffitt Cancer Center and Research Institute
T-cell Therapy in Combination With Nivolumab, Relatlimab and Ipilimumab for Patients With Metastatic Ovarian CancerNCT04611126
Metastatic Ovar...
Metastatic Fall...
Peritoneal Canc...
Ipilimumab
Cyclophosphamid
Fludarabine Pho...
Tumor Infiltrat...
Nivolumab
Relatlimab
18 Years - 75 YearsHerlev Hospital
Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic CancerNCT04146298
Pancreatic Canc...
Pancreatic Neop...
Pancreatic Duct...
Advanced Cancer
Cyclophosphamid...
Fludarabine
Mutant KRAS G12...
Anti-PD-1 monoc...
18 Years - 75 YearsChanghai Hospital
Adoptive Cell Therapy Across Cancer DiagnosesNCT03296137
Cancer
Autologous tumo...
Ipilimumab
Nivolumab
proleukin
Cyclophosphamid...
Fludara
18 Years - 70 YearsHerlev Hospital
CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic CancerNCT01218867
Metastatic Canc...
Metastatic Mela...
Renal Cancer
Anti-VEGFR2 CAR...
Cyclophosphamid...
Aldesleukin
Fludarabine
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
ACT-TIL and ANV419 for Advanced Melanoma.NCT05869539
Advanced Melano...
Combination of ...
18 Years - University Hospital, Basel, Switzerland
CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic CancerNCT01218867
Metastatic Canc...
Metastatic Mela...
Renal Cancer
Anti-VEGFR2 CAR...
Cyclophosphamid...
Aldesleukin
Fludarabine
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Adoptive Cell Therapy Long-term Follow-up (LTFU) StudyNCT03391778
Neoplasms
GSK adoptive ce...
- GlaxoSmithKline
ACT-TIL and ANV419 for Advanced Melanoma.NCT05869539
Advanced Melano...
Combination of ...
18 Years - University Hospital, Basel, Switzerland
Phase II Study of Short-Term Cultured Anti-Tumor Autologous Lymphocytes After Lymphocyte-Depleting Chemotherapy in Metastatic MelanomaNCT00513604
Melanoma
Malignant Melan...
Melanoma, Exper...
Experimental Me...
aldesleukin
therapeutic aut...
Cyclophosphamid...
Fludarabine pho...
Total body irra...
18 Years - National Institutes of Health Clinical Center (CC)
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of PembrolizumabNCT04536922
Metastatic HPV-...
Cyclophosphamid...
Fludarabine
Aldesleukin
Pembrolizumab (...
Individual Pati...
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Cell Therapy for Metastatic Melanoma Using CD8 Enriched Tumor Infiltrating LymphocytesNCT01236573
Skin Cancer
Metastatic Mela...
Fludarabine
Cyclophosphamid...
IL-12 transduce...
18 Years - 66 YearsNational Institutes of Health Clinical Center (CC)
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast CancerNCT06121557
Breast Neoplasm...
Surgery for har...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Camrelizumab
Chemotherapeuti...
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI...NCT01319565
Metastatic Mela...
Skin Cancer
Aldesleukin
Cyclophosphamid...
Fludarabine
Young TIL
Total Body Irra...
18 Years - 66 YearsNational Institutes of Health Clinical Center (CC)
Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic CancerNCT04146298
Pancreatic Canc...
Pancreatic Neop...
Pancreatic Duct...
Advanced Cancer
Cyclophosphamid...
Fludarabine
Mutant KRAS G12...
Anti-PD-1 monoc...
18 Years - 75 YearsChanghai Hospital
Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast CancerNCT06121570
Breast Neoplasm...
Sentinel Lymph ...
Doxorubicin
Epirubicin
Cyclophosphamid...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Nab-paclitaxel
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
The ACTIVATE (Adoptive Cell Therapy InVigorated to Augment Tumor Eradication) TrialNCT03158935
Advanced Ovaria...
Malignant Melan...
Cyclophosphamid...
Fludarabine
Pembrolizumab
Tumor-Infiltrat...
Interleukin-2 (...
18 Years - University Health Network, Toronto
Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid TumorsNCT05194735
Gynecologic Can...
Colorectal Canc...
Pancreatic Canc...
Non-small Cell ...
Cholangiocarcin...
Ovarian Cancer
Endometrial Can...
Ovarian Carcino...
Ovary Neoplasm
Squamous Cell L...
Adenocarcinoma ...
Adenosquamous C...
Neoantigen spec...
Aldesleukin (IL...
18 Years - Alaunos Therapeutics
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast CancerNCT05981001
Breast Neoplasm...
Surgery for har...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Camrelizumab
Nab-paclitaxel
Gemcitabine
Carboplatin
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Chemotherapy, Irradiation, Cell Infusions, and Interleukin-2 to Treat Metastatic MelanomaNCT00314106
Metastatic Mela...
Melanoma Reacti...
Cyclophosphamid...
IL-2
Fludarabine
1200 total body...
18 Years - National Institutes of Health Clinical Center (CC)
Chemotherapy Followed by Infusion of DMF5 Cells to Treat Metastatic MelanomaNCT00924001
Melanoma
Malignant Melan...
Melanoma, Exper...
DMF5 Melanoma R...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - National Institutes of Health Clinical Center (CC)
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of PembrolizumabNCT04536922
Metastatic HPV-...
Cyclophosphamid...
Fludarabine
Aldesleukin
Pembrolizumab (...
Individual Pati...
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of PembrolizumabNCT04536922
Metastatic HPV-...
Cyclophosphamid...
Fludarabine
Aldesleukin
Pembrolizumab (...
Individual Pati...
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Expanded Access Program of Lifileucel (LN-144) in Patients With Unresectable or Metastatic MelanomaNCT05398640
Unresectable Me...
Metastatic Mela...
Lifileucel
18 Years - Iovance Biotherapeutics, Inc.
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic MelanomaNCT01993719
Metastatic Mela...
Aldesleukin
Fludarabine
Fludarabine
Cyclophosphamid...
Cyclophosphamid...
Cyclophosphamid...
Young TIL
Pembrolizumab
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 PositiveNCT02111850
Cervical Cancer
Renal Cancer
Urothelial Canc...
Melanoma
Breast Cancer
Anti-MAGE-A3-DP...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast CancerNCT05981001
Breast Neoplasm...
Surgery for har...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Camrelizumab
Nab-paclitaxel
Gemcitabine
Carboplatin
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular MelanomaNCT01814046
Metastatic Ocul...
Metastatic Uvea...
Aldesleukin
Cyclophosphamid...
Fludarabine
Young Tumor Inf...
16 Years - 75 YearsNational Institutes of Health Clinical Center (CC)
A First-In-Human Trial of pTTL in Advanced Colorectal CancerNCT05908643
Colorectal Canc...
pTTL
18 Years - Neogap Therapeutics AB
Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLCNCT04069936
Non Small Cell ...
Lung Cancer
Lung Cancer Met...
Lung Cancer, No...
Non Small Cell ...
NSCLC
Non-small Cell ...
Non-small Cell ...
MILs™ - NSCLC
nivolumab
tadalafil
18 Years - WindMIL Therapeutics
ImmPACT Expanded Multiple Antigen Specific Endogenously Derived T Cells (MASE-T) to Patients With Metastatic MelanomaNCT04904185
Malignant Melan...
Cyclophosphamid...
Fludarabine Pho...
Multiple Antige...
Pembrolizumab
18 Years - 75 YearsHerlev Hospital
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast CancerNCT05981001
Breast Neoplasm...
Surgery for har...
Cyclophosphamid...
Fludarabine
Tumor-draining ...
Interleukin-2
Camrelizumab
Nab-paclitaxel
Gemcitabine
Carboplatin
18 Years - 70 YearsSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
A Study of DeTIL-0255 in Adults With Advanced MalignanciesNCT05107739
Platinum-resist...
Endometrial Can...
Cervical Cancer
Drug Product De...
18 Years - 70 YearsNurix Therapeutics, Inc.
A First-In-Human Trial of pTTL in Advanced Colorectal CancerNCT05908643
Colorectal Canc...
pTTL
18 Years - Neogap Therapeutics AB
A Study Evaluating UCART019 in Patients With Relapsed or Refractory CD19+ Leukemia and LymphomaNCT03166878
B Cell Leukemia
B Cell Lymphoma
UCART019
12 Years - 75 YearsChinese PLA General Hospital
CISH Inactivated TILs in the Treatment of NSCLCNCT05566223
Carcinoma, Non-...
Metastatic Non ...
Stage IV Non-sm...
Squamous Cell L...
Adenocarcinoma ...
Large Cell Lung...
Fludarabine
Cyclophosphamid...
CISH Inactivate...
Aldesleukin
Pembrolizumab
18 Years - 75 YearsIntima Bioscience, Inc.
The ACTIVATE (Adoptive Cell Therapy InVigorated to Augment Tumor Eradication) TrialNCT03158935
Advanced Ovaria...
Malignant Melan...
Cyclophosphamid...
Fludarabine
Pembrolizumab
Tumor-Infiltrat...
Interleukin-2 (...
18 Years - University Health Network, Toronto
Chemotherapy Followed by Infusion of DMF5 Cells to Treat Metastatic MelanomaNCT00924001
Melanoma
Malignant Melan...
Melanoma, Exper...
DMF5 Melanoma R...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - National Institutes of Health Clinical Center (CC)
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney CancerNCT00328861
Metastatic Mela...
Metastatic Kidn...
Natural Killer ...
IL-2
Cyclophosphamid...
Fludarabine
18 Years - National Institutes of Health Clinical Center (CC)
Expanded Access Program of Lifileucel (LN-144) in Patients With Unresectable or Metastatic MelanomaNCT05398640
Unresectable Me...
Metastatic Mela...
Lifileucel
18 Years - Iovance Biotherapeutics, Inc.
T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 PositiveNCT02111850
Cervical Cancer
Renal Cancer
Urothelial Canc...
Melanoma
Breast Cancer
Anti-MAGE-A3-DP...
Cyclophosphamid...
Fludarabine
Aldesleukin
18 Years - 70 YearsNational Institutes of Health Clinical Center (CC)
Phase II Study of Short-Term Cultured Anti-Tumor Autologous Lymphocytes After Lymphocyte-Depleting Chemotherapy in Metastatic MelanomaNCT00513604
Melanoma
Malignant Melan...
Melanoma, Exper...
Experimental Me...
aldesleukin
therapeutic aut...
Cyclophosphamid...
Fludarabine pho...
Total body irra...
18 Years - National Institutes of Health Clinical Center (CC)
Safety and Efficacy of OBX-115 in Advanced Solid TumorsNCT06060613
Tumor Skin
Metastatic Mela...
Melanoma
Lung Cancer
Metastatic Lung...
Non Small Cell ...
Metastatic Non ...
OBX-115
18 Years - Obsidian Therapeutics, Inc.
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