Spots Global Cancer Trial Database for leptomeningeal metastases
Every month we try and update this database with for leptomeningeal metastases cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer | NCT00005842 | Cancer | trastuzumab tipifarnib | 18 Years - | National Cancer Institute (NCI) | |
| ANG1005 in Leptomeningeal Disease From Breast Cancer | NCT03613181 | Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B... | ANG1005 Physician's Bes... | 18 Years - | Angiochem Inc | |
| Safety Study of Afatinib for Brain Cancer | NCT02423525 | Brain Cancer | Afatinib | 18 Years - | Saint John's Cancer Institute | |
| Study of Cerebrospinal Fluid Samples in Diagnosing Carcinomatous Meningitis in Patients With Cancer or Meningeal Syndrome | NCT00938756 | Brain and Centr... Breast Cancer Metastatic Canc... | diagnostic labo... immunoenzyme te... magnetic resona... | 18 Years - | National Cancer Institute (NCI) | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases | NCT00003020 | Brain and Centr... | LMB-7 immunotox... | 18 Years - | Duke University | |
| ANG1005 in Leptomeningeal Disease From Breast Cancer | NCT03613181 | Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B... | ANG1005 Physician's Bes... | 18 Years - | Angiochem Inc | |
| Safety Study of Afatinib for Brain Cancer | NCT02423525 | Brain Cancer | Afatinib | 18 Years - | Saint John's Cancer Institute | |
| Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases | NCT02616393 | Non-Small Cell ... Leptomeningeal ... Brain Metastase... | Tesevatinib | 18 Years - | Kadmon Corporation, LLC | |
| BATs in Patients With Breast Cancer and Leptomeningeal Metastases | NCT03661424 | Breast Cancer F... Leptomeningeal ... | HER2 BATs | 18 Years - | University of Virginia | |
| A Prospective, Observational Trial on the Diagnostic and Prognostic of LM | NCT02607605 | Lung Neoplasms Meningeal Carci... | 18 Years - 75 Years | Sun Yat-sen University | ||
| Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer | NCT00005842 | Cancer | trastuzumab tipifarnib | 18 Years - | National Cancer Institute (NCI) | |
| Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer | NCT01645839 | Breast Cancer Leptomeningeal ... | Liposomal Cytar... | 18 Years - | Centre Oscar Lambret | |
| Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases | NCT03520504 | Leptomeningeal ... | Proton craniosp... | 10 Years - | Memorial Sloan Kettering Cancer Center | |
| Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain | NCT00025311 | Brain and Centr... | topotecan hydro... | - 65 Years | NYU Langone Health | |
| Avelumab With Radiotherapy in Patients With Leptomeningeal Disease | NCT03719768 | Leptomeningeal ... Leptomeningeal ... | Avelumab Whole Brain Rad... | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Monoclonal Antibody Therapy in Treating Patients With Brain Metastases | NCT00002751 | Metastatic Canc... | monoclonal anti... | 3 Years - | Duke University | |
| A Prospective, Observational Trial on the Diagnostic and Prognostic of LM | NCT02607605 | Lung Neoplasms Meningeal Carci... | 18 Years - 75 Years | Sun Yat-sen University | ||
| Ipilimumab and Nivolumab in Leptomeningeal Metastases | NCT02939300 | Leptomeningeal ... | Nivolumab Ipilimumab | 18 Years - | Massachusetts General Hospital | |
| Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer | NCT00992602 | Central Nervous... Leptomeningeal ... Recurrent Breas... Stage IV Breast... Tumors Metastat... | methotrexate liposomal cytar... quality-of-life... laboratory biom... | 18 Years - | University of Washington | |
| Avelumab With Radiotherapy in Patients With Leptomeningeal Disease | NCT03719768 | Leptomeningeal ... Leptomeningeal ... | Avelumab Whole Brain Rad... | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. | NCT00854867 | Solid Tumour Ne... Brain Metastase... | Whole Brain Rad... Whole brain rad... | 18 Years - | Mundipharma Research Limited | |
| Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases | NCT03520504 | Leptomeningeal ... | Proton craniosp... | 10 Years - | Memorial Sloan Kettering Cancer Center | |
| Feasibility of Exosome Analysis in Cerebrospinal Fluid During the Diagnostic Workup of Metastatic Meningitis (Exo-LCR) | NCT05286684 | Breast Cancer | Consultation Cerebral and me... biological test | 18 Years - | Centre Oscar Lambret | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| ANG1005 in Leptomeningeal Disease From Breast Cancer | NCT03613181 | Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B... | ANG1005 Physician's Bes... | 18 Years - | Angiochem Inc | |
| Epothilone B in Treating Patients With CNS Metastases From Breast Cancer | NCT00450866 | Breast Cancer Metastatic Canc... | epothilone B | 18 Years - | Case Comprehensive Cancer Center | |
| Tomotherapy for Leptomeningeal Metastases | NCT04178343 | Leptomeningeal ... | tomotherapy | 18 Years - 75 Years | ChineseAMS | |
| Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC | NCT05813522 | Non Small Cell ... | Furmonertinib M... | 18 Years - | First Affiliated Hospital of Zhejiang University | |
| Epothilone B in Treating Patients With CNS Metastases From Breast Cancer | NCT00450866 | Breast Cancer Metastatic Canc... | epothilone B | 18 Years - | Case Comprehensive Cancer Center | |
| Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain | NCT00025311 | Brain and Centr... | topotecan hydro... | - 65 Years | NYU Langone Health | |
| Avelumab With Radiotherapy in Patients With Leptomeningeal Disease | NCT03719768 | Leptomeningeal ... Leptomeningeal ... | Avelumab Whole Brain Rad... | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. | NCT00854867 | Solid Tumour Ne... Brain Metastase... | Whole Brain Rad... Whole brain rad... | 18 Years - | Mundipharma Research Limited | |
| Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors | NCT00031928 | Brain and Centr... | mafosfamide | 3 Years - | National Cancer Institute (NCI) | |
| Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors | NCT04343573 | Leptomeningeal ... | Involved-field ... Proton Craniosp... Neurocognitive ... MDASI-BT and MD... | - 99 Years | Memorial Sloan Kettering Cancer Center | |
| Tomotherapy for Leptomeningeal Metastases | NCT04178343 | Leptomeningeal ... | tomotherapy | 18 Years - 75 Years | ChineseAMS | |
| Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. | NCT00854867 | Solid Tumour Ne... Brain Metastase... | Whole Brain Rad... Whole brain rad... | 18 Years - | Mundipharma Research Limited | |
| Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases | NCT03520504 | Leptomeningeal ... | Proton craniosp... | 10 Years - | Memorial Sloan Kettering Cancer Center | |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer | NCT03101579 | Leptomeningeal ... | Pemetrexed Dexamethasone Folic Acid Vitamin B12 | 18 Years - 75 Years | The First Hospital of Jilin University | |
| Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors | NCT00003462 | Brain and Centr... | busulfan | 18 Years - | Duke University | |
| Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | NCT01438021 | Leptomeningeal ... | pharmacological... methotrexate | 18 Years - | City of Hope Medical Center |
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