Infections

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Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

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Lung Neoplasms

Constriction, Pathologic

Tracheitis

Tracheal Stenosis

Tracheal Diseases

Communicable Diseases

Mycobacterium Infections

Bacterial Infections

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Bacterial Infections and Mycoses

Respiratory Tract Diseases

Respiratory Tract Infections

After resection of a segment of tracheal or bronchial lesion, reconstruct the airway with cryopreserved aortic allograft.

After resection of the tracheal or bronchial lesion with standard surgical techniques, the airway gap is reconstructed with a segment of human cryopreserved (-80 celsius degree) aortic allograft, which was not matched by the ABO and leukocyte antigen systems. The anastomosis is performed with standard technique for airway anastomosis. An Ultraflex covered tracheobronchial stent is inserted to prevent collapse for the aortic graft.

Cryopreserved aorta

Jin-Shing Chen, MD, PhD

We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.

Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices

The occurrence of complication including 1) anastomotic leakage, 2) pneumonia, 3) difficult weaning, 4) airway obstruction by granulation tissue, 5) stenosis.

National Taiwan University Hospital

Digestive System Diseases

Ear, Nose, and Throat Diseases

Gastroesophageal Reflux

Barrett Esophagus

Esophageal Motility Disorders

Esophageal Spasm, Diffuse

Deglutition Disorders

Esophageal Diseases

Gastrointestinal Diseases

Precancerous Conditions

Anna Nolan, MD

A majority of Fire Department of New York (FDNY) World Trade Center (WTC) exposed rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett's Esophagus (BE) and subsequent esophageal cancer. There is diminished health-related quality of life and productivity associated with aerodigestive diseases such as GERD and BE.

This proposal will leverage the longitudinally phenotyped WTC exposed cohort, validate biomarkers of WTC-aerodigestive disease, and develop novel, noninvasive disease phenotyping of premalignant diseases such as BE, and identify potential targeted therapeutics to improve care.

Blood, salivary samples, exhaled breath condensate (EBC), nasopharyngeal and oropharyngeal swabs.

Less than 1 % of the FDNY-HP subjects are female. As such our prior work has excluded females. In addition, due to this small sample size and since there is significant literature that biomarkers are different in these two sexes, the study team will not be enrolling females.

Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)

AERODIGESTIVE DISEASE IN THE WORLD TRADE CENTER EXPOSED FDNY COHORT: a Single Center Observational Study of Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)

Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices) will be shared.

Saliva will be analyzed using the Peptest. The value of \>/= 16 ng/mL indicates a positive salivary pepsin.

Histamine concentration will be measured with an enzymatic immunoassay

PAGI-QOL asks about how some of the gastrointestinal problems one may be experiencing (such as pain, discomfort, or other problems) may have affected one's overall quality of life and well-being in the past 2 weeks. PAGI-QOL consists of 30 questions, each scored from 0 (none of the time) to 5 (all of the time). The total score range is 0-150; the higher the score, the less the quality of life and well-being.

PAGI-SYM asks about the severity of symptoms one may have related one's gastrointestinal problem. The questionnaire consists of 20 symptoms, and each symptom is scored from 0 (none) to 5 (very severe). The total score range is 0-100; the higher the score, the more severe the symptoms.

SGRQ-C is designed to assess how one's breathing is troubling a participant and how it affects one's life. The questionnaire consists of 14 questions. The total score range is 0-54; the higher the score, the worse the chest trouble.

SF-36 captures mental health, general health perception, emotional, and social role functioning. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices	NCT04850742	Trachea Disease... Tracheal Stenos... Lung Cancer Tuberculosis; T... Airway Disease	Cryopreserved a...	20 Years -	National Taiwan University Hospital
Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)	NCT05216133	Airway Disease Barrett Esophag... Gastroesophagea...		37 Years - 90 Years	NYU Langone Health
Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)	NCT05216133	Airway Disease Barrett Esophag... Gastroesophagea...		37 Years - 90 Years	NYU Langone Health
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices	NCT04850742	Trachea Disease... Tracheal Stenos... Lung Cancer Tuberculosis; T... Airway Disease	Cryopreserved a...	20 Years -	National Taiwan University Hospital

Spots Global Cancer Trial Database for airway disease