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After resection of a segment of tracheal or bronchial lesion, reconstruct the airway with cryopreserved aortic allograft.

After resection of the tracheal or bronchial lesion with standard surgical techniques, the airway gap is reconstructed with a segment of human cryopreserved (-80 celsius degree) aortic allograft, which was not matched by the ABO and leukocyte antigen systems. The anastomosis is performed with standard technique for airway anastomosis. An Ultraflex covered tracheobronchial stent is inserted to prevent collapse for the aortic graft.

Cryopreserved aorta

Jin-Shing Chen, MD, PhD

We used a segment of cryopreserved aorta as a graft for reconstruction for long segment tracheobronchial lesion in human.

Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices

The occurrence of complication including 1) anastomotic leakage, 2) pneumonia, 3) difficult weaning, 4) airway obstruction by granulation tissue, 5) stenosis.

National Taiwan University Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices	NCT04850742	Trachea Disease... Tracheal Stenos... Lung Cancer Tuberculosis; T... Airway Disease	Cryopreserved a...	20 Years -	National Taiwan University Hospital
Feasibility of Tracheobronchial Reconstruction Using Bioengineered Aortic Matrices	NCT04850742	Trachea Disease... Tracheal Stenos... Lung Cancer Tuberculosis; T... Airway Disease	Cryopreserved a...	20 Years -	National Taiwan University Hospital

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