Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Syndrome

Polycystic Ovary Syndrome

Primary Ovarian Insufficiency

Menopause, Premature

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Vasodilator Agents

Platelet Aggregation Inhibitors

All Drugs and Chemicals

Micronutrients

Anticoagulants

Reproductive Control Agents

Hematinics

Other Dietary Supplements

Vitamins

Pentoxifylline

Thioctic Acid

Citric Acid

Sodium Citrate

Antioxidants

Clomiphene

Enclomiphene

Zuclomiphene

Phosphodiesterase Inhibitors

Enzyme Inhibitors

Protective Agents

Radiation-Protective Agents

Folic Acid

Vitamin B Complex

Trace Elements

Estrogens

Estrogen Antagonists

Estrogen Receptor Antagonists

Hormones

Hormone Antagonists

Estrogen Receptor Modulators

Selective Estrogen Receptor Modulators

Citrate

Alpha-lipoic Acid

Folate

Vitamin B9

ALA is sold as a dietary supplement, either by itself or incorporated into a multivitamin product. it also has anti-oxidant effect.

Alpha lipoic acid (ALA)

Pentoxifylline is a methylxanthine derivative which acts as a vasodilator by increasing blood flow to tissues, inhibits inflammatory responses, and reduces blood viscosity by impeding platelet aggregation

Pentoxifylline (PTX)

is a medication used to treat infertility in women who do not ovulate

Clomiphene Citrate

Nagwa Al Sabri, Phd

This study evaluate the addition of PTX and ALA to clomiphene citrate in the treatment of polycystic ovary.

Clomiphene, PTX and ALA each used in treatment of pco but they do so by different mechanisms.

Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.

PTX and ALA are used in treatment of pco due its anti-oxidant effect.

prospective randomized controlled open label study

Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate

Evaluation of the Effect of Pentoxifylline and α-Lipoic Acid as Adjunctive Therapy in Patients With Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Follicles measure more than 18 mm will be considered mature follicles.

Misr University for Science and Technology

Ain Shams University

principal investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate	NCT05231980	Clomiphene Citr... Resistant Ovary... Polycystic Ovar...	Alpha lipoic ac... Pentoxifylline ... Clomiphene Citr...	18 Years - 39 Years	Ain Shams University
Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate	NCT05231980	Clomiphene Citr... Resistant Ovary... Polycystic Ovar...	Alpha lipoic ac... Pentoxifylline ... Clomiphene Citr...	18 Years - 39 Years	Ain Shams University

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