Symptoms and General Pathology

All Conditions

Nervous System Diseases

Behaviors and Mental Disorders

Nutritional and Metabolic Diseases

Rare Diseases

Syndrome

Dementia

Metabolic Diseases

Chronic Disease

Alzheimer Disease

Brain Diseases

Central Nervous System Diseases

Tauopathies

Neurodegenerative Diseases

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Disease Attributes

Chronic Graft Versus Host Disease

Familial Alzheimer Disease

Anti-Infective Agents

Central Nervous System Depressants

All Drugs and Chemicals

Ethanol

general population in a specific area and specifc time range.

To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.

natural aging process

Jianwen Guo, MD

Bin Zhang, PhD

jianwen Guo, Dr

The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.

DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.

All biological specimens (including blood, feces, urine, saliva and tongue coating) will be stored in the biological resource center of the our research centers after written informed consent obtained from all subjects who voluntarily participated in this clinical study.

The Dampness Syndrome of Chinese Medicine Cohort Study

A Multi-Center Prospective Cohort Study of Dampness Syndrome in China

If you need to access or use the population information database and biological sample database, you must go through strict application and approval processes at first

This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments.

MoCA is a brief, 30-question test that helps healthcare professionals detect cognitive impairments very early on, allowing for faster diagnosis and patient care. MoCA is the most sensitive test available for detecting Alzheimer's disease, measuring executive functions and multiple cognitive domains. The value range 0-30: higher scores mean a better Cognitine. The score above 26 is considered the normal congnitive level

The EQ-5D comprises five dimensions of health: mobility, ability to self-care, ability to undertake usual activities, pain and discomfort, and anxiety and depression. . EQ-5D-5L, includes five levels of severity for each dimension (no problems, slight problems, moderate problems, severe problems, and extreme problems). The value range 0-100: higher scores mean a worse outcome.

MMSE is a widely used test of cognitive function among the elderly; it includes tests of orientation, attention, memory, language and visual-spatial skills. The value range 0-30: higher scores mean a better Cognitine.

Demographic characteristic, life style. disease history, allergies will be involoved.

WBC, RBC, PLT , HB, NEUT% and LYM% will be tested and recorded. Above or below each mormal value will be considered as abnormal.

urinary WBC and urinary RBC will be observed. negative or below 5/HP is normal.

BLO and GLU and PRO in urine will also be test. Negative is normal.

cells in faeces will be tested such as RBC and WBC. Negative occult blood（FOB) is difined normal.

The researchers will check the results of ALT and AST. TBil, DBIL, TBA and TP, ALB. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.

The researchers will check the results of Cr， BUN, TC， LDL， HDL,UA and fasting blood glucose，glycosylanted. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.

The researchers will check the change of P, QRS and ST segments separately in electrocardiogram.

change of brain MRI. The investigators will focus on the change of hippocampal volume and the spacing of temporal sulcus gyrus.

State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine

Guangzhou University of Traditional Chinese Medicine

Gland and Hormone Related Diseases

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Eye Diseases

Immune System Diseases

Diseases and Abnormalities at or Before Birth

Heart and Blood Diseases

Skin and Connective Tissue Diseases

Wounds and Injuries

Diabetes Mellitus

Diabetes Mellitus, Type 2

Uterine Cervical Neoplasms

Macular Degeneration

Stress Disorders, Post-Traumatic

Parkinson Disease

Lewy Body Disease

Paralysis

Parkinsonian Disorders

Diabetes Mellitus, Type 1

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Sclerosis

Multiple Sclerosis

Atrophy

Stress Disorders, Traumatic

Vaginal Neoplasms

Vulvar Neoplasms

Motor Neuron Disease

Amyotrophic Lateral Sclerosis

Huntington Disease

Uterine Neoplasms

Frontotemporal Dementia

Aphasia, Primary Progressive

Pick Disease of the Brain

Supranuclear Palsy, Progressive

Corticobasal Degeneration

Multiple System Atrophy

Shy-Drager Syndrome

Neuronal Ceroid-Lipofuscinoses

Aphasia

Late Onset Disorders

Glucose Metabolism Disorders

Endocrine System Diseases

Ganglion Cysts

Synovial Cyst

Basal Ganglia Diseases

Movement Disorders

Synucleinopathies

Autoimmune Diseases

Demyelinating Autoimmune Diseases, CNS

Autoimmune Diseases of the Nervous System

Demyelinating Diseases

Endocrine Gland Neoplasms

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Genital Neoplasms, Female

Urogenital Neoplasms

Gonadal Disorders

Uterine Cervical Diseases

Uterine Diseases

Retinal Degeneration

Retinal Diseases

Trauma and Stressor Related Disorders

Pathological Conditions, Anatomical

Neuromuscular Diseases

Spinal Cord Diseases

TDP-43 Proteinopathies

Proteostasis Deficiencies

Chorea

Dyskinesias

Heredodegenerative Disorders, Nervous System

Genetic Diseases, Inborn

Cognition Disorders

Vulvar Diseases

Autonomic Nervous System Diseases

Primary Dysautonomias

Hypotension

Vascular Diseases

Frontotemporal Lobar Degeneration

Speech Disorders

Language Disorders

Communication Disorders

Neurobehavioral Manifestations

Neurologic Manifestations

Ophthalmoplegia

Ocular Motility Disorders

Cranial Nerve Diseases

Vaginal Diseases

Lipidoses

Subjects in this group will have a diagnosis and/or medical history of a condition, disease, genetic background, or trait of interest.

Subjects in this group will serve as healthy controls.

Skin biopsy (2-3mm) and/or blood (up to 50 mL); saliva; excess/ leftover biospecimens that were (or will be) collected for other purposes (e.g., medical procedure).

Biological Sample Collection

Becca Wood

Lisa Voltolina

Scott Noggle

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store the samples for future use.

Through this research, researchers hope to identify future treatments or even cures for the major diseases of our time.

Researchers at the New York Stem Cell Foundation (NYSCF) Research Institute study diverse diseases, conditions, and traits by creating stem cells from biological samples. These "pluripotent" stem cells can become any cell in the human body, including cells that may be difficult, invasive, or impossible to obtain directly.

Additionally, researchers perform genetic testing to learn more about DNA, a material in most cells that contains instructions for the body's development and functions (such as traits like eye color and risk of certain diseases). A piece of DNA that determines the specific role of a cell is called a "gene." If the instructions in a gene are abnormal, this can lead to disease.

Participation in the study involves: (1) completion of health questionnaires, (2) providing a skin and/or blood sample from which stem cells may be created, (3) collection of a saliva sample for genetic analysis, and (4) possible future followup to provide additional information or learn about other research studies.

This study is not a clinical trial.

Skin biopsy (2-3mm) and/or blood (up to 50 mL); saliva; excess/leftover biospecimens that were (or will be) collected for other purposes (e.g., medical procedure)

NYSCF Scientific Discovery Biobank

Establishment of a diverse repository of biological samples, stem cell lines, derivatives, and associated information to support investigations into the biology, etiology, manifestations, progression, risk factors, genetic underpinnings, and treatment of diseases, conditions, and traits.

New York Stem Cell Foundation Research Institute

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Dampness Syndrome of Chinese Medicine Cohort Study	NCT05315895	Chronic Disease Cancer Dementia Alzhei... Metabolic Disea... Aging Alzheimer Disea...	natural aging p...	35 Years - 79 Years	Guangzhou University of Traditional Chinese Medicine
NYSCF Scientific Discovery Biobank	NCT06203106	ALS Amyotrophic Lat... Alzheimer Disea... Alzheimer Disea... Alzheimer Disea... Batten Disease Corticobasal De... Dementia Frontotemporal ... Huntington Dise... Lewy Body Disea... Multiple Sclero... Multiple System... Parkinson Disea... Parkinson's Dis... Progressive Sup... INAD Diabetes Diabetes Mellit... Diabetes Mellit... Diabetes Mellit... Macular Degener... Ovarian Cancer Cervical Cancer Uterine Cancer Vaginal Cancer Vulvar Cancer PTSD Post Traumatic ...	Biological Samp...	30 Days -	New York Stem Cell Foundation Research Institute
The Dampness Syndrome of Chinese Medicine Cohort Study	NCT05315895	Chronic Disease Cancer Dementia Alzhei... Metabolic Disea... Aging Alzheimer Disea...	natural aging p...	35 Years - 79 Years	Guangzhou University of Traditional Chinese Medicine

Spots Global Cancer Trial Database for alzheimer disease, early onset