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general population in a specific area and specifc time range.

To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.

natural aging process

Jianwen Guo, MD

Bin Zhang, PhD

jianwen Guo, Dr

The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.

DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.

All biological specimens (including blood, feces, urine, saliva and tongue coating) will be stored in the biological resource center of the our research centers after written informed consent obtained from all subjects who voluntarily participated in this clinical study.

The Dampness Syndrome of Chinese Medicine Cohort Study

A Multi-Center Prospective Cohort Study of Dampness Syndrome in China

If you need to access or use the population information database and biological sample database, you must go through strict application and approval processes at first

This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments.

MoCA is a brief, 30-question test that helps healthcare professionals detect cognitive impairments very early on, allowing for faster diagnosis and patient care. MoCA is the most sensitive test available for detecting Alzheimer's disease, measuring executive functions and multiple cognitive domains. The value range 0-30: higher scores mean a better Cognitine. The score above 26 is considered the normal congnitive level

The EQ-5D comprises five dimensions of health: mobility, ability to self-care, ability to undertake usual activities, pain and discomfort, and anxiety and depression. . EQ-5D-5L, includes five levels of severity for each dimension (no problems, slight problems, moderate problems, severe problems, and extreme problems). The value range 0-100: higher scores mean a worse outcome.

MMSE is a widely used test of cognitive function among the elderly; it includes tests of orientation, attention, memory, language and visual-spatial skills. The value range 0-30: higher scores mean a better Cognitine.

Demographic characteristic, life style. disease history, allergies will be involoved.

WBC, RBC, PLT , HB, NEUT% and LYM% will be tested and recorded. Above or below each mormal value will be considered as abnormal.

urinary WBC and urinary RBC will be observed. negative or below 5/HP is normal.

BLO and GLU and PRO in urine will also be test. Negative is normal.

cells in faeces will be tested such as RBC and WBC. Negative occult blood（FOB) is difined normal.

The researchers will check the results of ALT and AST. TBil, DBIL, TBA and TP, ALB. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.

The researchers will check the results of Cr， BUN, TC， LDL， HDL,UA and fasting blood glucose，glycosylanted. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.

The researchers will check the change of P, QRS and ST segments separately in electrocardiogram.

change of brain MRI. The investigators will focus on the change of hippocampal volume and the spacing of temporal sulcus gyrus.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Dampness Syndrome of Chinese Medicine Cohort Study	NCT05315895	Chronic Disease Cancer Dementia Alzhei... Metabolic Disea... Aging Alzheimer Disea...	natural aging p...	35 Years - 79 Years	Guangzhou University of Traditional Chinese Medicine
The Dampness Syndrome of Chinese Medicine Cohort Study	NCT05315895	Chronic Disease Cancer Dementia Alzhei... Metabolic Disea... Aging Alzheimer Disea...	natural aging p...	35 Years - 79 Years	Guangzhou University of Traditional Chinese Medicine

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