Neoplasms

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Carcinoma, Hepatocellular

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

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Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

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Liver Extracts

anatomical liver resection by means of IOUS-finger compression

anatomical liver resection

Non-anatomical liver resection

Guido Torzilli, MD, PhD

Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC

Anatomical Liver Resection by Means of Ultrasound-guided Vessel Compression Versus Non-anatomical Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial

University of Milan

Symptoms and General Pathology

Neoplasm Metastasis

Neoplastic Processes

Anatomical resection was defined as resection of 1 or more complete hepatic segments in our study, including bisegmentectomy, right hemihepatectomy, left hemihepatectomy, extended right hemihepatectomy, extended left hemihepatectomy, single segmentectomy, caudate lobectomy, or a combination of these.

Nonanatomical resection known as wedge resection, was defined as resection of the tumor with a margin of normal parenchyma without regard to hepatic anatomy.

Based upon the segmental anatomy of the liver according to Couinaud system, AR was defined as resection of 1 or more complete hepatic segments in our study, including bisegmentectomy, right hemihepatectomy, left hemihepatectomy, extended right hemihepatectomy, extended left hemihepatectomy, single segmentectomy, caudate lobectomy, or a combination of these. NAR, known as wedge resection, was defined as resection of the tumor with a margin of normal parenchyma without regard to hepatic anatomy.

Anatomical Resection

The type of liver resection (anatomical resection, AR or nonanatomical resection, NAR) for colorectal liver metastases (CRLM) is subject to debate. The debate may persist because some certain prognostic factors, associated with aggressive biological behavior of tumor, have been overlooked. The aim of our study was to investigate the characteristics of patients who would benefit more from anatomical resection for colorectal liver metastases.

729 patients who underwent hepatic resection of CRLM were retrospectively collected from June 2012and May 2019. Treatment effects between AR and NAR were compared in full subgroup analyses. Tumor relapse-free survival (RFS) was evaluated by a stratified log-rank test and summarized with the use of Kaplan-Meier and Cox proportional hazards methods.

Anatomical Resection in Colorectal Liver Metastases Patients

Relapse-free survival since patients undergoing hepatic resection

Overall survival since patients undergoing hepatic resection

Fudan University

Head of Colorectal Surgery

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Anatomical resection with systematic lymph-node dissection

anatomical resection

Anatomical resection with systematic lymph-node dissection is currently the standard of care for the treatment of early stage non-small cell lung cancer. The use of minimally invasive approaches has increased greatly over the last two decades \[either video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS)\], as they provide the patient with better outcomes than open thoracotomy. Minimally invasive VATS lobectomy for a standard case is generally a straightforward procedure for a well-trained surgical team, although concomitant preoperative pathologies or intraoperative findings/adverse events may result in technical difficulties, leading to intraoperative conversion, commonly by thoracotomy.

The investigators aimed to assess long-term outcomes in a consecutive cohort of patients treated by anatomical pulmonary resection either using VATS, VATS requiring intraoperative conversion to thoracotomy, or upfront open thoracotomy for lung-cancer surgery.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC	NCT01236989	Patients Affect... Disease-Free Su... Overall Surviva...	anatomical live... Non-anatomical ...	-	University of Milan
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC	NCT01236989	Patients Affect... Disease-Free Su... Overall Surviva...	anatomical live... Non-anatomical ...	-	University of Milan
Anatomical Resection in Colorectal Liver Metastases Patients	NCT05673564	The Characteris...	Anatomical Rese...	18 Years - 79 Years	Fudan University
Intraoperative Conversion During Video-assisted Thoracoscopy Resection for Lung Cancer Does Not Alter Survival	NCT04663191	Video-assisted ... Lung Cancer Lobectomy Survival Surgery	anatomical rese...	18 Years -	Centre Hospitalier Universitaire, Amiens

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