Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Substance Related Disorders

Nervous System Diseases

Symptoms and General Pathology

Rare Diseases

Keratosis, Actinic

Keratosis

Poisoning

Arsenic Poisoning

Skin Diseases

Precancerous Conditions

Chemically-Induced Disorders

Heavy Metal Poisoning

Syndrome

Neurotoxicity Syndromes

Chronic Graft Versus Host Disease

Antineoplastic Agents

All Drugs and Chemicals

Herbal and Botanical

Other Dietary Supplements

Allyl sulfide

Antioxidants

Protective Agents

Enzyme Inhibitors

Cytochrome P-450 Enzyme Inhibitors

Garlic

Diallyl Sulfide

One soft capsule of garlic oil (10 mg) daily for 12 weeks

Garlic oil

Mir Misbahuddin, MBBS, PhD

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. Similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.

Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment.

Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis.

Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Prof. and Chairman, Department of Pharmacology

Melanosis

Hyperpigmentation

Pigmentation Disorders

Micronutrients

Selenium

Sodium Selenite

Selenious Acid

Trace Elements

Patients who receive treatment (selenium)

200 micrograms (µg) of selenium in the form of sodium selenite; capsule form consumed once daily with breakfast.

sodium selenite

dicalcium phosphate capsule matching the selenium capsule in appearance; consumed once daily with breakfast

placebo

Julian E Spallholz, PhD

Paul F La Porte, PhD

Selim Ahmed, MBBS, FCPS

Context: Approximately 100 million people throughout the world consume water contaminated with arsenic at levels above carcinogenic thresholds, including 40 million in Bangladesh alone, with up to one-fourth of deaths attributed to arsenic exposure in the worst-affected regions. There are no proven therapies for treating chronic arsenic toxicity or for preventing arsenical cancers. Selenium has been known to counter arsenic toxicity in a variety of animal models. The investigators have recently shown in animals and humans that this effect is mediated by the formation of \[(GS)2AsSe\]- , the seleno-bis(S-glutathionyl) arsinium ion, which is then rapidly excreted via the hepatobiliary system. Concurrently, two Phase II studies in China and Bangladesh have suggested clinical benefit to selenium supplementation in arsenicosis patients.

Objective: To assess whether daily selenium supplementation counters arsenic toxicity in patients exposed to drinking water arsenic. If proven effective, selenium supplementation might be safely and cost-effectively implemented in the worst-affected localities.

Selenium in the Treatment of Arsenic Toxicity and Cancers

Selenite in the Detoxification of Arsenic and the Prevention of Arsenical Melanosis and Cancers Amongst Bangladeshi Arsenicosis Patients: A 48-week, Randomized, Double-blinded, Placebo-controlled Phase III Trial

Arsenical melanosis was recorded in 4 quadrants of each patients' torsos using the Dermlite epiluminescence microscopy system. The images were then scored in a blinded, randomized fashion by a dermatologist.

The levels of arsenic in patients' blood was measured to determine whether intervention had a differential effect.

The levels of arsenic in patients' urine was measured to determine whether intervention had a differential effect.

National Cancer Institute (NCI)

American Cancer Society, Inc.

Texas Tech University

Professor of Nutrition & Biochemistry, Division of Nutritional Sciences, College of Human Sciences, Texas Tech University.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis	NCT01748669	Chronic Arsenic...	Garlic oil	20 Years - 60 Years	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis	NCT01748669	Chronic Arsenic...	Garlic oil	20 Years - 60 Years	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Selenium in the Treatment of Arsenic Toxicity and Cancers	NCT01442727	Arsenical Melan... Arsenical Kerat... Arsenical Cance... Arsenicosis Arsenic Exposur... Arsenic Toxicit... Arsenic Poisoni...	sodium selenite placebo	12 Years - 55 Years	Texas Tech University

Spots Global Cancer Trial Database for arsenicosis

Every month we try and update this database with for arsenicosis cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for arsenicosis

Every month we try and update this database with for arsenicosis cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for arsenicosis cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.