Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Immune System Diseases

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Heart and Blood Diseases

Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Behaviors and Mental Disorders

Eye Diseases

Blood and Lymph Conditions

Musculoskeletal Diseases

Digestive System Diseases

Infections

Mouth and Tooth Diseases

Rare Diseases

Dermatitis, Atopic

Dermatitis

Eczema

Multiple Sclerosis

Sclerosis

Kidney Diseases

Stroke

Diabetes Mellitus

Syndrome

Myasthenia Gravis

Asthma

Alzheimer Disease

Macular Degeneration

Lymphoma

Leukemia

Scleroderma, Systemic

Scleroderma, Diffuse

Heart Diseases

Anemia, Sickle Cell

Thalassemia

beta-Thalassemia

Psoriasis

Arthritis

Crohn Disease

Spondylitis

Parkinson Disease

Thyroid Diseases

Hepatitis A

Hepatitis

Liver Cirrhosis

Fibrosis

Schizophrenia

Hypersensitivity

Cystic Fibrosis

Autistic Disorder

Amyloidosis

Graves Disease

Colitis

Fibromyalgia

Myofascial Pain Syndromes

Colitis, Ulcerative

Ulcer

Spondylarthritis

Vasculitis

Hidradenitis Suppurativa

Hidradenitis

Vitiligo

Alopecia

Alopecia Areata

Celiac Disease

Spondylitis, Ankylosing

Behcet Syndrome

Hepatitis, Autoimmune

Pemphigus

Epilepsy

Epilepsies, Myoclonic

Anemia

Liver Diseases

Gastrointestinal Diseases

Hepatitis, Viral, Human

Virus Diseases

Communicable Diseases

Enterovirus Infections

Picornaviridae Infections

RNA Virus Infections

Joint Diseases

Parkinsonian Disorders

Ganglion Cysts

Synovial Cyst

Basal Ganglia Diseases

Brain Diseases

Central Nervous System Diseases

Movement Disorders

Synucleinopathies

Neurodegenerative Diseases

Mental Disorders

Psychotic Disorders

Schizophrenia Spectrum and Other Psychotic Disorders

Autoimmune Diseases

Demyelinating Autoimmune Diseases, CNS

Autoimmune Diseases of the Nervous System

Demyelinating Diseases

Dementia

Tauopathies

Neurocognitive Disorders

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Skin Diseases

Pancreatic Diseases

Lung Diseases

Respiratory Tract Diseases

Genetic Diseases, Inborn

The study may require a tissue collection and/or a participant survey for participation. Most tissue collected will come from a blood draw; up to 100mL for the health condition group, 60mL for the exceptive condition group, and up to 180mL for the control group (if determined safe for the participant). Participant surveys may involve participant reported outcomes (PROs) or custom participant surveys.

Specimen sample

Carolyn Bidwell

Houman Hemmati, MD

To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions.

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

To collect enough biospecimens and associated clinical data to allow researchers to come to statistically relevant scientific results

Sanguine Biosciences

Cholangitis

Choledochal Cyst

Cysts

Cholangitis, Sclerosing

Biliary Atresia

Bile Duct Diseases

Biliary Tract Diseases

Congenital Abnormalities

Digestive System Abnormalities

Hepatitis, Chronic

Bile Duct Cysts

Autoimmune Hepatitis

Primary Sclerosing Cholangitis

Chronic Graft Versus Host Disease

Hematinics

All Drugs and Chemicals

Liver Extracts

The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort.

The same inclusion/exclusion criteria were applied for the same center prospectively. It is a external validation cohort.

Clinical models were developed and validated to predict liver-related complications and survival outcomes in pediatric patients with biopsy-proven with cirrhosis.

Prediction model

Yuhan Yang, MD

The aim of this study was to developed and validated models to predict hepatic decompensation and survivals in pediatric patients with cirrhosis and compared these models with currently available models.

Noninvasive liver fibrosis tests such as the NAFLD fibrosis score (NFS), Hepascore, and transient elastography were specifically developed to predict fibrosis and can help predict patients with NAFLD at the highest risk of developing liver-related complications. These tests have been widely applied in adult cirrhosis. The accuracy of these models, however, may be influenced by patient factors including age, body mass index, and diabetes, potentially limiting their prognostic accuracy and clinical practicability in children. Therefore, it is currently unknown how to best predict hepatic decompensation and survival outcomes among pediatric patients with cirrhosis. To fill this knowledge gap, the investigators performed a retrospective-prospective cohort study with the aim of developing and validating a clinical model to predict liver-related complications and survival outcomes in pediatric patients with biopsy-proven with cirrhosis. Secondly, the investigators aimed to compare the predictive accuracy with currently available noninvasive model.

Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis

The primary outcome was the first event of hepatic decompensation, defined by the occurrence of any of the following: ascites (identified or confirmed by abdominal ultrasound), upper gastrointestinal bleeding secondary to portal hypertension (confirmed by endoscopy in the presence of gastroesophageal varices or portal hypertensive gastropathy), or hepatic encephalopathy (established by clinical parameters, neuropsychological tests, or electroencephalogram)

The endpoint was defined as the occurrence of death or the last follow-up. Patients were followed from the day of liver biopsy until the occurrence of death, liver transplant, or last visit. The outcome was evaluated by an experienced hepatologist in each center every 3-6 months. At each visit, a medical history, physical examination, and standard laboratory tests were performed.

West China Hospital

Associate Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives	NCT05635266	Age-Related Mac... Allergies Alpha-Gal Syndr... Alzheimer Disea... Amyloidosis Ankylosing Spon... Arthritis Alopecia Areata Asthma Atopic Dermatit... Autism Autoimmune Hepa... Behcet's Diseas... Beta-Thalassemi... Cancer Celiac Disease Kidney Diseases COPD Crohn Disease Cystic Fibrosis Diabetes Dravet Syndrome DMD Fibromyalgia Graves Disease Thyroid Disease... Hepatitis Hidradenitis Su... ITP Leukemia ALS Lupus or SLE Lymphoma Multiple Sclero... Myasthenia Grav... Heart Diseases Parkinson Disea... Pemphigus Vulga... Cirrhosis Psoriasis Schizophrenia Scleroderma Sickle Cell Dis... Stroke Ulcerative Coli... Vasculitis Vitiligo	Specimen sample	18 Years - 85 Years	Sanguine Biosciences
Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis	NCT05181332	Cirrhosis Biliary Atresia Choledochal Cys... Primary Scleros... HBV HCV Autoimmune Hepa...	Prediction mode...	0 Years - 18 Years	West China Hospital

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