Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Immune System Diseases

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Heart and Blood Diseases

Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Behaviors and Mental Disorders

Eye Diseases

Blood and Lymph Conditions

Musculoskeletal Diseases

Digestive System Diseases

Infections

Mouth and Tooth Diseases

Rare Diseases

Dermatitis, Atopic

Dermatitis

Eczema

Multiple Sclerosis

Sclerosis

Kidney Diseases

Stroke

Diabetes Mellitus

Syndrome

Myasthenia Gravis

Asthma

Alzheimer Disease

Macular Degeneration

Lymphoma

Leukemia

Scleroderma, Systemic

Scleroderma, Diffuse

Heart Diseases

Anemia, Sickle Cell

Thalassemia

beta-Thalassemia

Psoriasis

Arthritis

Crohn Disease

Spondylitis

Parkinson Disease

Thyroid Diseases

Hepatitis A

Hepatitis

Liver Cirrhosis

Fibrosis

Schizophrenia

Hypersensitivity

Cystic Fibrosis

Autistic Disorder

Amyloidosis

Graves Disease

Colitis

Fibromyalgia

Myofascial Pain Syndromes

Colitis, Ulcerative

Ulcer

Spondylarthritis

Vasculitis

Hidradenitis Suppurativa

Hidradenitis

Vitiligo

Alopecia

Alopecia Areata

Celiac Disease

Spondylitis, Ankylosing

Behcet Syndrome

Hepatitis, Autoimmune

Pemphigus

Epilepsy

Epilepsies, Myoclonic

Anemia

Liver Diseases

Gastrointestinal Diseases

Hepatitis, Viral, Human

Virus Diseases

Communicable Diseases

Enterovirus Infections

Picornaviridae Infections

RNA Virus Infections

Joint Diseases

Parkinsonian Disorders

Ganglion Cysts

Synovial Cyst

Basal Ganglia Diseases

Brain Diseases

Central Nervous System Diseases

Movement Disorders

Synucleinopathies

Neurodegenerative Diseases

Mental Disorders

Psychotic Disorders

Schizophrenia Spectrum and Other Psychotic Disorders

Autoimmune Diseases

Demyelinating Autoimmune Diseases, CNS

Autoimmune Diseases of the Nervous System

Demyelinating Diseases

Dementia

Tauopathies

Neurocognitive Disorders

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Skin Diseases

Pancreatic Diseases

Lung Diseases

Respiratory Tract Diseases

Genetic Diseases, Inborn

The study may require a tissue collection and/or a participant survey for participation. Most tissue collected will come from a blood draw; up to 100mL for the health condition group, 60mL for the exceptive condition group, and up to 180mL for the control group (if determined safe for the participant). Participant surveys may involve participant reported outcomes (PROs) or custom participant surveys.

Specimen sample

Carolyn Bidwell

Houman Hemmati, MD

To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions.

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

To collect enough biospecimens and associated clinical data to allow researchers to come to statistically relevant scientific results

Sanguine Biosciences

Hypertrophy

Cicatrix, Hypertrophic

Cicatrix

Keloid

Pain

Lichen Planus

Prurigo

Acne Vulgaris

Scleroderma, Localized

Neurodermatitis

Cysts

Granuloma

Granuloma Annulare

Epidermal Cyst

Keratoacanthoma

Muir-Torre Syndrome

Skin Diseases, Papulosquamous

Hypotrichosis

Hair Diseases

Pathological Conditions, Anatomical

Skin Diseases, Eczematous

Lichenoid Eruptions

Exanthema

Rheumatic Diseases

Collagen Diseases

Connective Tissue Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Necrobiotic Disorders

Prurigo Nodularis

Lichen Planopilaris

Frontal Fibrosing Alopecia

Morphea

Localized Scleroderma

Anti-Arrhythmia Agents

Channel Blockers

Central Nervous System Depressants

All Drugs and Chemicals

Lidocaine

Anesthetics

Anesthetics, Local

Sodium Channel Blockers

Diuretics, Potassium Sparing

This arm will include an injection mixture of corticosteroid and lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with lidocaine

Corticosteroid with normal saline

Brian Drolet, MD

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment.

Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure.

The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.

Pain Outcomes Following Intralesional Corticosteroid Injections

The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial

IPD will not be shared with other researchers

Assessed using the visual analog scale (0-10 scale). Zero indicates no pain, 10 indicates worst pain ever.

Vanderbilt University Medical Center

Assistant Professor

This arm will include an injection mixture of corticosteroid and lidocaine

Corticosteroid with lidocaine: Intralesional corticosteroid injection

Corticosteroid With Lidocaine

This arm will include a mixture of corticosteroid and normal saline. The purpose of normal saline is to keep the volume and concentration similar when compared to the injections containing lidocaine.

Corticosteroid with normal saline: Intralesional corticosteroid injection

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives	NCT05635266	Age-Related Mac... Allergies Alpha-Gal Syndr... Alzheimer Disea... Amyloidosis Ankylosing Spon... Arthritis Alopecia Areata Asthma Atopic Dermatit... Autism Autoimmune Hepa... Behcet's Diseas... Beta-Thalassemi... Cancer Celiac Disease Kidney Diseases COPD Crohn Disease Cystic Fibrosis Diabetes Dravet Syndrome DMD Fibromyalgia Graves Disease Thyroid Disease... Hepatitis Hidradenitis Su... ITP Leukemia ALS Lupus or SLE Lymphoma Multiple Sclero... Myasthenia Grav... Heart Diseases Parkinson Disea... Pemphigus Vulga... Cirrhosis Psoriasis Schizophrenia Scleroderma Sickle Cell Dis... Stroke Ulcerative Coli... Vasculitis Vitiligo	Specimen sample	18 Years - 85 Years	Sanguine Biosciences
Pain Outcomes Following Intralesional Corticosteroid Injections	NCT03630198	Keloid Alopecia Areata Acne Hypertrophic Sc... Epidermal Inclu... Frontal Fibrosi... Lichen Plano-Pi... Keratoacanthoma Plaque Psoriasi... Lichen Simplex ... Prurigo Nodular... Nummular Eczema Granuloma Annul... Morphea Lichen Planus	Corticosteroid ... Corticosteroid ...	12 Years -	Vanderbilt University Medical Center

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