Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Infections

Mouth and Tooth Diseases

Symptoms and General Pathology

Breast Neoplasms

Gingivitis

Breast Diseases

Skin Diseases

Communicable Diseases

Gingival Diseases

Periodontal Diseases

Mouth Diseases

Stomatognathic Diseases

The division was made into 2 groups: Patients with breast cancer and gingivitis (BC/G) (n=20); and control patients with gingivitis only (G) (n=20).

Clinical periodontal examinations were carried out by a single trained and calibrated examiner. Clinical periodontal, hematological and salivary flow parameters were assessed at baseline, 6 weeks, 12 and 24 weeks.

All patients received oral hygiene instructions (interproximal cleaning with floss and interdental brushes, brushing instructions on the Bass technique). The patients were also encouraged to brush the back of the tongue once a day. Subsequently, all patients underwent supragingival scaling, prophylaxis, and polishing. Supragingival scaling was performed using manual instruments (Gracey curettes) and an ultrasonic device.

Basic Periodontal Therapy

Objective: To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT).

Methods: They were divided into patients with breast cancer and gingivitis (BC/G =20); and patients without cancer with gingivitis (G=20). Clinical parameters \[Plaque Index (PI), bleeding on probing (BOP), Probing Depth (PS), Clinical Attachment Level (CAL)\], hematological parameters (complete blood count), and salivary flow were evaluated at baseline, 6, 12 and 24 weeks.

Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer

Integrating Periodontal Therapy and Biofilm Management Into Breast Cancer Patients' Care: Periodontal, Hematological and Salivary Parameters Assessment Before and During Chemotherapy

The plaque index (PI) was determined by analyzing the presence or absence of biofilm on the gingival margin, expressed as a percentage of surfaces with biofilm Bleeding on probing (BOP) was determined by detecting the presence or absence of bleeding, expressed as the percentage of bleeding surfaces.

The probing depth (PD/mm) was expressed in millimeters, measured from the gingival margin to the bottom of the gingival sulcus.

The clinical attachment level (CAL/mm) was expressed in millimeters, measured from the cementoenamel junction to the most apical portion of the gingival sulcus.

Both BOP, PD, CAL were evaluated at six locations per tooth, i.e., three on the buccal surface and three on the lingual or palatal surface.

Periodontal parameters (BOP, PD, CAL and PI ) are evaluated together or combined to perform periodontal diagnosis

The salivary flow rate was expressed in milliliters per minute (mL/min). Periodontal parameters and salivary flow will be combined to assess oral health.

Daniela Bazan Palioto

University of Sao Paulo

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer	NCT06212908	Breast Cancer Gingivitis Periodontal	Basic Periodont...	18 Years - 70 Years	University of Sao Paulo
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer	NCT06212908	Breast Cancer Gingivitis Periodontal	Basic Periodont...	18 Years - 70 Years	University of Sao Paulo

Spots Global Cancer Trial Database for basic periodontal therapy