Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Neoplasms

Gland and Hormone Related Diseases

Digestive System Diseases

Rare Diseases

Kidney Diseases

Carcinoma

Adenocarcinoma

Carcinoma, Renal Cell

Neuroendocrine Tumors

Urologic Neoplasms

Endocrine Gland Neoplasms

Urogenital Neoplasms

Kidney Neoplasms

Carcinoid Tumor

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenoma

Adenoma, Islet Cell

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urologic Diseases

Male Urogenital Diseases

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Nerve Tissue

Endocrine System Diseases

Pancreatic Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Renal Cell Carcinoma

Neuroendocrine Tumor

Clear Cell Renal Cell Carcinoma

Pancreatic Neuroendocrine Tumor

Neuroepithelioma

Pancreatic Cancer

Antineoplastic Agents

All Drugs and Chemicals

Anti-Infective Agents

Angiogenesis Inhibitors

Sirolimus

Angiogenesis Inducing Agents

Temsirolimus

MTOR Inhibitors

Patients with clear cell renal cell carcinoma with metastases.

Patients with low grade neuro-endocrine tumours with metastases.

We obtain 10mL blood of the patients. The blood is obtained twice: once with angiogenesis inhibitors or mTOR inhibitors, and once without.

Blood sampling by vena punction.

Sjoukje F. Oosting, MD

Marloes A.M. Peters

The primary objective of this study is to analyse the concentration dopamine and serotonin in thrombocytes of patients with renal cell carcinoma and neuro-endocrine tumours compared to the concentrations of these catecholamines in healthy volunteers. The concentration dopamine and serotonin in thrombocytes with and without medication will also be evaluated.

* To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and low grade neuroendocrine tumours.
* To compare these concentrations with the concentrations catecholamines in thrombocytes of healthy controls.
* To analyse the concentration catecholamines in thrombocytes of patients with clear cell renal cell carcinoma and patients with low grade neuroendocrine tumours with and without medication.

2 x 10mL whole blood, stored as platelet rich and platelet poor plasma.

Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.

University Medical Center Groningen

Symptoms and General Pathology

Neoplasm Metastasis

Neoplastic Processes

In vitro tests will be performed after blood sample collection from metastatic cancer patients

José AM Barbuto, Ph.D

The purpose of this study is to evaluate in vitro the potential of peptides, to modify, phenotypically and functionally, the monocyte-derived dendritic cells of patients with metastatic cancer.

The DCs will be generated in vitro from peripheral blood mononuclear cells (PBMCs) which will be obtained from 30 ml of peripheral blood collected from each patient with metastatic cancer by venipuncture in heparin tubes.

The cellular viability, the expression of maturation biomarkers and the presence of several cytokines will be evaluated by flow cytometric assays after the culture period of DCs exposed to the peptides.

An interim analysis is programmed with the first 10 patients. If an effect is demonstrated the study will include an additional number of subjects sufficient to ensure adequate comparison with other commercially available peptides.

In Vitro Functional Modulation of Monocyte-derived Dendritic Cells of Patients With Cancer by Peptides

Recepta Biopharma

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.	NCT01398306	Carcinoma Carcinoma, Rena... Neuroendocrine ... Carcinoid Tumor Pancreatic Isle...	Blood sampling ...	18 Years -	University Medical Center Groningen
In Vitro Functional Modulation of Monocyte-derived Dendritic Cells of Patients With Cancer by Peptides	NCT02159937	Metastatic Canc...	Blood sampling ...	18 Years -	Recepta Biopharma
Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.	NCT01398306	Carcinoma Carcinoma, Rena... Neuroendocrine ... Carcinoid Tumor Pancreatic Isle...	Blood sampling ...	18 Years -	University Medical Center Groningen

Spots Global Cancer Trial Database for blood sampling by vena punction.