Neoplasms

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Neoplasms, Connective Tissue

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Gastrointestinal Neoplasms

Digestive System Neoplasms

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Amino Acids

Tyrosine Kinase Inhibitors

Tyrosine

Blood will be withdrawn at baseline and in intervals of 3 months for a total period of 2 years

Nikolas von Bubnoff, PD Dr.

Activating mutations of the kinases CKIT or PDGFRA can be detected in 90% of cases by DNA sequence analysis of a pathological specimen. These mutated genomic DNA fragments are highly specific for the tumor and are released by the tumor into the circulation. Allele-specific PCR can be used to specifically amplify and quantify mutated CKIT and PDGFR DNA fragments.

The current trial aims to evaluate whether tumor DNA carrying mutations for CKIT and PDGFRA can be detected and quantified in the plasma of patients with active GIST, and whether detection can be correlated with the clinical course of disease either under therapy or in progressive disease irrespective of current therapy.

Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)

Prospective, Explorative Trial for the Detection of Circulating Cell-free Tumor DNA in the Plasma of Patients With Gastrointestinal Stromal Tumors (GIST)Harboring Activating Mutations of CKIT or PDGFRA Pre/Post Surgery or Pre/Under Treatment With a Tyrosine Kinase Inhibitor or Progressive Disease Irrespective of Current or Planned Treatment. An Open-label, Non-randomized, Multicenter Phase IIIb Clinical Trial

Technical University of Munich

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)	NCT01462994	Gastrointestina...	Blood will be w...	18 Years -	Technical University of Munich
Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)	NCT01462994	Gastrointestina...	Blood will be w...	18 Years -	Technical University of Munich

Spots Global Cancer Trial Database for blood will be withdrawn at baseline and in intervals of 3 months for a total period of 2 years