Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Keratosis, Actinic

Keratosis

Skin Diseases

Precancerous Conditions

Dermatologic Agents

All Drugs and Chemicals

Photosensitizing Agents

Topical retinoid and Light therapy with photosensitizing agent

Light therapy with photosensitizing agent

Topical Retinoid - Apply to AKs for 4 weeks Photo-therapy with photosensitizing agent- Apply to AKs at week 4

Topical retinoid and blue-light therapy with photosensitizing agent

Photo-therapy with sensitizing agent - apply to AKs at week 4

Photodynamic Therapy (PDT)

Murad Alam, MD

Evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy for the treatment of actinic keratoses.

Evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy vs photodynamic therapy alone for the treatment of actinic keratoses.

Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic Keratoses

A Randomized Controlled Paired Comparison of Photo-therapy With a Topical Retinoid Cream Pretreatment Versus PDT Alone for Actinic Keratoses

Northwestern University

Associate Professor of Dermatology

Aminolevulinic Acid

Subjects will receive zero time of incubation with ALA (5-aminolevulinic acid) before photodynamic blue light therapy.

Subjects will receive one hour of incubation with ALA (5-aminolevulinic acid) before photodynamic blue light therapy.

ALA (5-aminolevulinic acid) will be applied to subjects' skin for either zero time incubation or one hour incubation

ALA (5-aminolevulinic acid)

Blue light therapy

This is a randomized clinical trial evaluating blue light 5-aminolevulinic acid (ALA) photodynamic therapy with different incubation times for the treatment of actinic keratosis.

Subjects who are interested in participating, currently living in the Chicago metropolitan area, and meet inclusion and exclusion criteria will be enrolled in the study. Subjects will be randomized to either 1) zero time ALA incubation or 2) 1 hour ALA incubation. Demographic and health data will be collected prior to treatment initiation. Three visits will be conducted: screening, treatment, and follow up visit at 8 weeks.

This study is a pilot study designed to determine feasibility of this procedure.

Photodynamic Therapy Incubation Times for Actinic Keratosis

A Randomized Controlled Trial Evaluating 5-aminolevulinic Acid Photodynamic Therapy With Different Incubation Times for the Treatment of Actinic Keratosis

The number of AK lesions will be counted by a live, blinded assessor at baseline and at Week 8 follow-up visit.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic Keratoses	NCT00756288	Actinic Keratos...	Topical retinoi... Photodynamic Th...	18 Years - 80 Years	Northwestern University
Photodynamic Therapy Incubation Times for Actinic Keratosis	NCT03066843	Actinic Keratos...	ALA (5-aminolev... Blue light ther...	18 Years -	Northwestern University
Photodynamic Therapy Incubation Times for Actinic Keratosis	NCT03066843	Actinic Keratos...	ALA (5-aminolev... Blue light ther...	18 Years -	Northwestern University

Spots Global Cancer Trial Database for blue light therapy