Spots Global Cancer Trial Database for actinic keratoses

Every month we try and update this database with for actinic keratoses cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Patient Decision Aid for the Treatment of Actinic Keratosis	NCT06008171	Actinic Keratos... Patient Decisio...	Patient Decisio...	18 Years -	Maastricht University Medical Center
Study to Evaluate the Safety, Tolerability and Efficacy of BF-200 ALA (Ameluz®) in the Field-directed Treatment of Actinic Keratosis (AK) on the Extremities and Neck/Trunk With Photodynamic Therapy (PDT) Using a RhodoLED Lamp	NCT05662202	Actinic Keratos...	BF-200 ALA and ... Vehicle and red...	18 Years -	Biofrontera Bioscience GmbH
ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipients	NCT00865878	Actinic Keratos... Skin Neoplasms	Aminolevulinic ... Vehicle	18 Years -	DUSA Pharmaceuticals, Inc.
High- and Low-risk Actinic Keratosis Referrals to Secondary Care	NCT05976061	Actinic Keratos...		18 Years -	Maastricht University Medical Center
Nevus Doctor Clinical Decision Support for GPs	NCT03246412	Melanoma (Skin) Non-melanoma Sk... Actinic Keratos...	Nevus doctor cl...	18 Years - 120 Years	University Hospital of North Norway
Topical Imiquimod Cream in Combination With Cryotherapy for the Treatment of Actinic Keratoses	NCT00774787	Actinic Keratos...	imiquimod 5% cr...	18 Years -	Rigel Dermatology
Multicenter Study to Assess the Efficacy and Safety of Methyl Aminolevulinate Hydrochloride (MAL) 16.8% Cream (CD06809-41) Versus Vehicle Cream for Actinic Keratosis of the Face	NCT04085367	Actinic Keratos...	MAL 16.8% cream MAL Vehicle Cre...	18 Years -	Galderma R&D
Therapeutic Equivalence of Diclofenac Sodium Gel 3% vs Solaraze ® in the Treatment of Actinic Keratosis	NCT03826550	Actinic Keratos...	Diclofenac Sodi... Solaraze 3% Top... Placebo	18 Years -	Encube Ethicals Pvt. Ltd.
Pharmacokinetic Study to Evaluate the Extent of Systemic Absorption of PEP005	NCT00544258	Actinic Keratos...	PEP005	18 Years -	Peplin
Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)	NCT01000636	Actinic Keratos...	Metvix PDT	18 Years -	Galderma R&D
Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times	NCT02622594	Actinic Keratos...	Aminolevulinic ... Environ Cosmeti... BLU-U IIllumina...	18 Years -	Dermatology, Laser & Vein Specialists of the Carolinas
Bioequivalence of Generic Imiquimod Cream, 5% When Compared to Aldara™ (Imiquimod) Cream, 5% in the Treatment of Actinic Keratosis	NCT00948428	Actinic Keratos...	imiquimod Aldara™ Vehicle Cream	18 Years -	Actavis Inc.
An Open-Label 18-Month Safety Study of Fluorouracil Cream 0.5% for the Treatment of Actinic Keratoses	NCT00377273	Actinic Keratos...	fluorouracil cr...	18 Years -	Sanofi
The Influence of an E-learning Program on Recognition of Actinic Keratosis	NCT05987553	Actinic Keratos... E-learning Dermatology	e-learning prog...	18 Years - 67 Years	Maastricht University Medical Center
A Bioequivalence Study With Clinical Endpoints Comparing Generic Imiquimod Cream, 3.75% and Zyclara™ (Imiquimod) Cream, 3.75% in Subjects With Actinic Keratoses	NCT01502020	Actinic Keratos...	imiquimod cream... Vehicle Cream imiquimod cream...	18 Years -	Actavis Mid-Atlantic LLC
Phase 3b Study of Metvix NDL-PDT Versus Metvix c-PDT in Subjects With Actinic Keratoses	NCT01821391	Actinic Keratos...	NDL-PDT c-PDT placebo c-PDT	18 Years -	Galderma R&D
Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses	NCT01475071	Actinic Keratos...	Metvix and natu... Metvix and conv...	18 Years -	Galderma R&D
Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic Keratosis	NCT05937529	Actinic Keratos...	Cream containin... Daylight PDT	18 Years - 100 Years	Bispebjerg Hospital
A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	NCT00742391	Actinic Keratos...	PEP005 (ingenol... Vehicle gel	18 Years -	Peplin
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trial	NCT04875026	Actinic Keratos...	5-fluorouracil ... Dexeryl	18 Years -	Pierre Fabre Medicament
Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratoses	NCT00175643	Actinic Keratos...	imiquimod	18 Years - 75 Years	University of British Columbia
A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on Actinic Keratosis on Face or Scalp (AK004)	NCT03285490	Actinic Keratos...	KX2-391 Ointmen... Placebo	18 Years -	Almirall, S.A.
Daylight-mediated Photodynamic Therapy of Actinic Keratoses:Comparing 0.2%HAL With 16%MAL	NCT02149342	Actinic Keratos...	Hexylaminolaevu... Methylaminolaev...	18 Years -	Joint Authority for Päijät-Häme Social and Health Care
Phase II AK Study in Organ Transplant Patients	NCT00829192	Actinic Keratos... Carcinoma, Squa... Organ Transplan...	Afamelanotide (... Placebo	18 Years - 75 Years	Clinuvel Pharmaceuticals Limited
OCT and Invasion in Cutaneous Skin Lesions	NCT06014697	Cutaneous Squam... Bowen's Disease Actinic Keratos... Keratosis, Acti... Diagnosis	Optical Coheren... Clinical assess...	-	Maastricht University Medical Center
Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients With Actinic Keratosis	NCT05202860	Actinic Keratos... Basal Cell Carc... Squamous Cell C...	HPV Vaccine PLACEBO vaccine	18 Years -	Bispebjerg Hospital
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients	NCT01538901	Actinic Keratos...	photodynamic th... imiquimod 5% cr...	18 Years - 80 Years	Medical University of Vienna
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients	NCT01538901	Actinic Keratos...	photodynamic th... imiquimod 5% cr...	18 Years - 80 Years	Medical University of Vienna
Continuous Quality Improvement (CQI) Pilot Study Evaluating the Utility of an Educational Video	NCT02062853	Actinic Keratos...	Video Group Verbal Group	18 Years -	University of California, Davis
Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis	NCT03575780	Actinic Keratos...	KX2-391 Ointmen...	18 Years -	Athenex, Inc.
Actinic Keratoses Treatment With Metvix® in Combination With Light	NCT02373371	Actinic Keratos...	Metvix® Photodynamic Th... Photodynamic Th...	18 Years -	University Hospital, Limoges
A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on Actinic Keratosis on Face or Scalp (AK004)	NCT03285490	Actinic Keratos...	KX2-391 Ointmen... Placebo	18 Years -	Almirall, S.A.
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis	NCT05078827	Actinic Keratos...	Test Product (A... Reference Produ... Placebo Product...	18 Years -	Encube Ethicals Pvt. Ltd.
Efficacy and Safety of Tixel Treatment on Facial and/or Scalp Actinic Keratoses.	NCT05365386	Actinic Keratos...	Tixel C	18 Years - 80 Years	Novoxel Ltd.
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trial	NCT04875026	Actinic Keratos...	5-fluorouracil ... Dexeryl	18 Years -	Pierre Fabre Medicament
Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion	NCT00926952	Actinic Keratos...	Methylaminolevu... Photodynamic Th...	18 Years -	Innovaderm Research Inc.
A Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic Therapy	NCT02451579	Actinic Keratos...	Antihistamine C... Placebo	19 Years -	Goldman, Butterwick, Fitzpatrick and Groff
Combination Topical Therapy for Treatment of Scalp Actinic Keratoses	NCT03996252	Actinic Keratos...	Calcipotriene 0... Efudex 5% Topic...	40 Years -	Tulane University
Single-Center Study Evaluating Systemic Exposure and Safety of KX2-391 Ointment 1% on the Face or Balding Scalp in Subjects With Actinic Keratosis	NCT03575780	Actinic Keratos...	KX2-391 Ointmen...	18 Years -	Athenex, Inc.
Comparing Immune Responses to Topical Imiquimod	NCT04809662	Actinic Keratos...	Imiquimod	18 Years - 85 Years	University of California, Davis
Earliest Stage Treatment of Aktinic Keratosis With Imiquimod 3.75% Cream	NCT04842422	Actinic Keratos...	Imiquimod 3.75%...	50 Years -	Medical University of Graz
SMAD4 Methylation and Expression Levels in Non-melanocytic Skin Cancers; SMAD4 Protein Positivity	NCT04759261	Basal Cell Carc...	SMAD4 expressio...	18 Years - 80 Years	Trakya University
Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratoses	NCT00175643	Actinic Keratos...	imiquimod	18 Years - 75 Years	University of British Columbia
Microwave Therapy for Treatment of Precancerous Actinic Keratoses	NCT03483935	Actinic Keratos... Precancerous Sk...	Microwave treat...	18 Years -	University of Dundee
PDT vs Peels for Treatment of Actinic Keratoses	NCT04429308	Actinic Keratos...	Photodynamic Th... Chemical Peels	18 Years -	Northwestern University
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients	NCT01538901	Actinic Keratos...	photodynamic th... imiquimod 5% cr...	18 Years - 80 Years	Medical University of Vienna
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia	NCT03906253	Actinic Keratos... Aging Non-Melanoma Sk...	Fractionated La...	60 Years -	Wright State University
Gene and Protein Expression Profiles After Treatment of Actinic Keratoses	NCT05740969	Actinic Keratos...	5Fluorouracil Imiquimod Melatonin	18 Years -	Zealand University Hospital
Investigation of the Effect of Lipikar Baume AP+M	NCT06385340	Actinic Keratos...	Lipikar Baume A...	18 Years -	CentroDerm GmbH
Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic Keratosis	NCT05937529	Actinic Keratos...	Cream containin... Daylight PDT	18 Years - 100 Years	Bispebjerg Hospital
A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	NCT00942604	Actinic Keratos...	PEP005 (ingenol... Vehicle gel	18 Years -	Peplin
Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic Keratoses	NCT00756288	Actinic Keratos...	Topical retinoi... Photodynamic Th...	18 Years - 80 Years	Northwestern University
Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo	NCT01354717	Actinic Keratos...	Brand Carac Generic 0.5% 5-... Placebo cream	45 Years - 85 Years	Spear Pharmaceuticals
Tirbanibulin 1% Ointment for the Treatment of Actinic Keratosis on the Back of the Hands	NCT06026358	Actinic Keratos...	Tirbanibulin	18 Years - 99 Years	Medical University of Graz
Effects of Topical Diclofenac on Tumor Metabolism	NCT01935531	Actinic Keratos...	3% diclofenac i...	18 Years -	University Hospital Regensburg
Daylight-PDT With MAL for AK and Photodamaged Skin	NCT02736760	Actinic Keratos... Photodamaged Sk...	Daylight photod... Cryosurgery	40 Years -	University Hospital Regensburg
A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic Keratosis	NCT06135415	Keratosis, Acti...	Tirbanibulin Vehicle ointmen...	18 Years -	Almirall, S.A.
A Study to Follow up Recurrence Rates of Actinic Keratoses One Year After Completion of Study 1487-IMIQ	NCT00189254	Actinic Keratos...	Imiquimod	18 Years -	Viatris Inc.
Nicotinamide for Prevention of Pre-malignant Actinic Keratosis in Kidney Transplant Recipients	NCT04843553	Actinic Keratos...	Oral Nicotinami...	-	Rhode Island Hospital
A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations	NCT00942604	Actinic Keratos...	PEP005 (ingenol... Vehicle gel	18 Years -	Peplin
Photodynamic Therapy Incubation Times for Actinic Keratosis	NCT03066843	Actinic Keratos...	ALA (5-aminolev... Blue light ther...	18 Years -	Northwestern University
SMAD4 Methylation and Expression Levels in Non-melanocytic Skin Cancers; SMAD4 Protein Positivity	NCT04759261	Basal Cell Carc...	SMAD4 expressio...	18 Years - 80 Years	Trakya University
The Influence of an E-learning Program on Recognition of Actinic Keratosis	NCT05987553	Actinic Keratos... E-learning Dermatology	e-learning prog...	18 Years - 67 Years	Maastricht University Medical Center
A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalp	NCT03285477	Actinic Keratos...	Placebo KX2-391 Ointmen...	18 Years -	Almirall, S.A.
5-ALA Patch-PDT of Actinic Keratosis on the Upper Extremities	NCT03606122	Actinic Keratos...	PD P 506 A	18 Years -	photonamic GmbH & Co. KG
The Effect of Efudex Treatment on Photoaged Skin	NCT00121511	Photo-aging Keratosis	Efudex (5-fluor...	50 Years -	University of Michigan
Patient Decision Aid for the Treatment of Actinic Keratosis	NCT06008171	Actinic Keratos... Patient Decisio...	Patient Decisio...	18 Years -	Maastricht University Medical Center
Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)	NCT01000636	Actinic Keratos...	Metvix PDT	18 Years -	Galderma R&D
Effect of Lipikar Urea 30% Before Actinic Keratoses Treatment	NCT06274320	Actinic Keratos...	Group A: holist... Group B: Tolak®...	18 Years -	Cosmetique Active International
Impact of Madecassoside and 5 % Panthenol Cream in Post Photodynamic Therapy for Actinic Keratosis	NCT05937529	Actinic Keratos...	Cream containin... Daylight PDT	18 Years - 100 Years	Bispebjerg Hospital
Safety and Effectiveness Study of Imiquimod Creams for Treatment of Actinic Keratoses (AKs)	NCT00605176	Actinic Keratos...	imiquimod cream imiquimod cream Placebo	18 Years -	Graceway Pharmaceuticals, LLC
HRQoL Keratinocyte Carcinomas	NCT04814953	Basal Cell Carc... Squamous Cell C... Actinic Keratos...	questionnaires	18 Years - 100 Years	University Hospital, Ghent
Bioequivalence of Generic Imiquimod Cream, 5% When Compared to Aldara™ (Imiquimod) Cream, 5% in the Treatment of Actinic Keratosis	NCT00948428	Actinic Keratos...	imiquimod Aldara™ Vehicle Cream	18 Years -	Actavis Inc.
Comparing Immune Responses to Topical Imiquimod	NCT04809662	Actinic Keratos...	Imiquimod	18 Years - 85 Years	University of California, Davis
Photodynamic Therapy Incubation Times for Actinic Keratosis	NCT03066843	Actinic Keratos...	ALA (5-aminolev... Blue light ther...	18 Years -	Northwestern University
Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses	NCT06027619	Actinic Keratos...	Topical aminole... Red light illum...	18 Years -	Case Comprehensive Cancer Center
Pharmacokinetic Study to Evaluate the Extent of Systemic Absorption of PEP005	NCT00544258	Actinic Keratos...	PEP005	18 Years -	Peplin
Investigation of the Effect of Lipikar Baume AP+M	NCT06385340	Actinic Keratos...	Lipikar Baume A...	18 Years -	CentroDerm GmbH
Multicenter Study to Assess the Efficacy and Safety of Methyl Aminolevulinate Hydrochloride (MAL) 16.8% Cream (CD06809-41) Versus Vehicle Cream for Actinic Keratosis of the Face	NCT04085367	Actinic Keratos...	MAL 16.8% cream MAL Vehicle Cre...	18 Years -	Galderma R&D
Phase I/IIa Trial to Evaluate AVX001 Gel in Doses of 1% or 3% Compared With Vehicle Over Four Weeks of Field-directed Treatment Period in Adult Subjects With AK	NCT05164393	Actinic Keratos...	AVX001	18 Years -	Coegin Pharma AB

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