Neoplasms

Gland and Hormone Related Diseases

All Conditions

Thyroid Neoplasms

Thyroid Diseases

Hyperthyroidism

Endocrine System Diseases

Micronutrients

Anti-Infective Agents

All Drugs and Chemicals

Iodine

Cadexomer iodine

Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from the stomach of patients infected with H.pylori.

Also to test the hypothesis that CagA virulent strains of H.pylori are more common in patients with thyroid cancer than with other thyroid diseases.

Objective To test eradicate H.pylori after administration of radioactive iodine (131I) to patients with thyroid diseases and to evaluate their H.pylori CagA status .

Design Observational study

Setting

The Isotopic Institute at the Rabin Medical Center, Campus Beilinson Patients Consecutive patients with thyroid diseases referred to the Isotopic Institute at the Rabin Medical Center, Campus Beilinson for either radioactive iodine (131I) thyroid scan or radioactive iodine (131I)treatment for their disease, will be screened, prior to the radioactive iodine, for H. pylori infection and CagA protein by serology. Patient with positive serology for H. pylori will be tested for active gastric infection using the H.pylori stool antigen test. The study population will include all patients who tested positive for H.pylori both by serology and stool antigen tests. Six to eight weeks and 6 month after administration of radioactive iodine (131I) treatment , stool antigen or H.pylori will be tested again to confirm persistence of H.pylori eradication.

Main Outcome Measure confirmed H.pylori eradication by the stool antigen test. The rate of infection with virulent and caricogenic CagA H.pylori ,will be tested using the immunoblot assay.

Summary

We will test in this study whether Helicobacter pylori is eradicated, after radioactive iodine (131I) administration, from the stomach of patients with thyroid diseases. The rate of CagA virulent and carcinogenic H.pylori infection in theses patients will be assessed.

The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication

Effect of Radioactive Iodine on Eradication of Helicobacter Pylori in Patients Treated for Thyroid Diseases

Rabin Medical Center

Haim Shmuely, MD

Infections

Symptoms and General Pathology

Digestive System Diseases

Rare Diseases

Communicable Diseases

Ulcer

Stomach Neoplasms

Gastrointestinal Diseases

Stomach Ulcer

Duodenal Ulcer

Gastrointestinal Neoplasms

Digestive System Neoplasms

Stomach Diseases

Peptic Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Cancer

patients who will undergo EGD for gastric ulcer

patients who will undergo EGD for duodenal ulcer

patients who will undergo EGD for stomach cance

Sang Kil Lee, MD

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR

Yonsei University

Study title	NCT ID	Conditions	Eligibility	Organization
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication	NCT00822289	Helicobacter Py... Thyroid Cancer ... Hyperthyroidism	18 Years - 85 Years	Rabin Medical Center
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA	NCT03057171	Helicobacter Py... Gastric Ulcer Duodenal Ulcer Stomach Cancer	19 Years -	Yonsei University
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication	NCT00822289	Helicobacter Py... Thyroid Cancer ... Hyperthyroidism	18 Years - 85 Years	Rabin Medical Center

Spots Global Cancer Trial Database for caga

Every month we try and update this database with for caga cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for caga

Every month we try and update this database with for caga cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for caga cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.