Neoplasms

Gland and Hormone Related Diseases

All Conditions

Thyroid Neoplasms

Thyroid Diseases

Hyperthyroidism

Endocrine System Diseases

Micronutrients

Anti-Infective Agents

All Drugs and Chemicals

Iodine

Cadexomer iodine

Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from the stomach of patients infected with H.pylori.

Also to test the hypothesis that CagA virulent strains of H.pylori are more common in patients with thyroid cancer than with other thyroid diseases.

Objective To test eradicate H.pylori after administration of radioactive iodine (131I) to patients with thyroid diseases and to evaluate their H.pylori CagA status .

Design Observational study

Setting

The Isotopic Institute at the Rabin Medical Center, Campus Beilinson Patients Consecutive patients with thyroid diseases referred to the Isotopic Institute at the Rabin Medical Center, Campus Beilinson for either radioactive iodine (131I) thyroid scan or radioactive iodine (131I)treatment for their disease, will be screened, prior to the radioactive iodine, for H. pylori infection and CagA protein by serology. Patient with positive serology for H. pylori will be tested for active gastric infection using the H.pylori stool antigen test. The study population will include all patients who tested positive for H.pylori both by serology and stool antigen tests. Six to eight weeks and 6 month after administration of radioactive iodine (131I) treatment , stool antigen or H.pylori will be tested again to confirm persistence of H.pylori eradication.

Main Outcome Measure confirmed H.pylori eradication by the stool antigen test. The rate of infection with virulent and caricogenic CagA H.pylori ,will be tested using the immunoblot assay.

Summary

We will test in this study whether Helicobacter pylori is eradicated, after radioactive iodine (131I) administration, from the stomach of patients with thyroid diseases. The rate of CagA virulent and carcinogenic H.pylori infection in theses patients will be assessed.

The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication

Effect of Radioactive Iodine on Eradication of Helicobacter Pylori in Patients Treated for Thyroid Diseases

Rabin Medical Center

Haim Shmuely, MD

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Herbal and Botanical

Hormones

Caraway

Hypothyroid patients taking levothyroxin.

Carum Cravi

Placebo

Seyed Rasoul Zakavi, MD,IBNM

Zohre Mousavi, MD, IBE

Zohre Mousavi, MD,IBE

Fateme Khani

Maryam Naghibi

Seyed Rasoul Zakavi, MD. IBNM

Mohammad Ramezani, Ph.D., Pharm.D

Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.

Effect of Carum Carvi on Thyroid Hormones and TSH Level

Evaluation of the Effect of Carum Carvi on Levels of Plasma Thyroid Hormones and TSH Level in Patients on Thyroid Hormone Therapy and Normal Controls.

Pharmaceutical Research Center

Mashhad University of Medical Sciences

Seyed Rasoul Zakavi

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication	NCT00822289	Helicobacter Py... Thyroid Cancer ... Hyperthyroidism		18 Years - 85 Years	Rabin Medical Center
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication	NCT00822289	Helicobacter Py... Thyroid Cancer ... Hyperthyroidism		18 Years - 85 Years	Rabin Medical Center
Effect of Carum Carvi on Thyroid Hormones and TSH Level	NCT01471288	Thyroid Cancer ...	Carum Cravi Placebo	18 Years - 65 Years	Mashhad University of Medical Sciences

Spots Global Cancer Trial Database for thyroid cancer patients