Infections

All Conditions

Symptoms and General Pathology

Neoplasms

Digestive System Diseases

Rare Diseases

Communicable Diseases

Ulcer

Stomach Neoplasms

Gastrointestinal Diseases

Stomach Ulcer

Duodenal Ulcer

Gastrointestinal Neoplasms

Digestive System Neoplasms

Stomach Diseases

Peptic Ulcer

Duodenal Diseases

Intestinal Diseases

Stomach Cancer

patients who will undergo EGD for gastric ulcer

patients who will undergo EGD for duodenal ulcer

patients who will undergo EGD for stomach cance

Sang Kil Lee, MD

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR

Yonsei University

Anti-Inflammatory Agents

All Drugs and Chemicals

IL-1, TNF-alpha, Il-10

Mitsushige Sugimoto

MItsushige Sugimoto

Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. We intended to clarify the association between polymorphisms of pro-inflammatory and anti-inflammatory cytokines, and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.

H. pylori infection has close associations with the development of peptic ulcer diseases as well as gastric cancer, gastric adenoma, and gastric MALT lymphoma. The association of the host genetics with the susceptibility to various gastroduodenal disorders has been intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H. pylori infection .

In chronic active gastritis induced by H. pylori infection, activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines. In fact, levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H. pylori.

Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases. Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. However, the roles of the IL-10 polymorphisms on the pathogenesis of H. pylori-related gastric cancer and peptic ulcer have not been fully elucidated.It is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan. Then, we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.

Cytokine Gene Polymorphisms in Gastric Diseases

Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese

Yokoyama Foundation for Clinical Pharmacology

Hamamatsu University

Nutritional and Metabolic Diseases

Blood and Lymph Conditions

Immune System Diseases

Ear, Nose, and Throat Diseases

Syndrome

Esophageal Neoplasms

Obesity

Irritable Bowel Syndrome

Crohn Disease

Gastroesophageal Reflux

Colonic Polyps

Colitis

Colitis, Ulcerative

Gallstones

Cholelithiasis

Cholecystolithiasis

Celiac Disease

Polyps

Esophagitis

Eosinophilic Esophagitis

Barrett Esophagus

Metaplasia

Gastritis

Colitis, Microscopic

Colitis, Lymphocytic

Inflammatory Bowel Diseases

Gastroenteritis

Colonic Diseases

Esophageal Diseases

Colonic Diseases, Functional

Precancerous Conditions

Eosinophilia

Leukocyte Disorders

Hematologic Diseases

Hypersensitivity

Hypersensitivity, Immediate

Biliary Tract Diseases

Gallbladder Diseases

Calculi

Pathological Conditions, Anatomical

Esophageal Motility Disorders

Esophageal Spasm, Diffuse

Deglutition Disorders

Malabsorption Syndromes

Metabolic Diseases

Esophageal Cancer

Eosinophilic Gastroenteritis

Hematinics

Herbal and Botanical

Liver Extracts

Cola

Participants with Eosinophilic esophagitis

Participants with Gastroesophageal Reflux Disease (GERD).

Participants with intestinal metaplasia (risk factor for esophageal cancer).

Participants with Lymphocytic/Microscopic Colitis.

Momchilo Vuyisich

This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and remissions, or progression of their disease.

This is a longitudinal, observational study whose main goal is to identify the human and microbial determinants of gastrointestinal diseases. Molecular and metadata will be collected from a large study population at multiple time points. Machine learning will be applied to all data, and models will be evaluated for development of novel diagnostic and therapeutic tools.

Systems Biology of Gastrointestinal and Related Diseases

Identification of biomarkers that indicate gastrointestinal diseases.

Identification of microbial species that indicate gastrointestinal disease.

Prediction of the efficacy of a biologic medication against IBD based on molecular data and metadata.

Development of a molecular test for C. difficile infection (CDI)

Quantification of changes observed in the microbiome post colonoscopy.

Viome

Heart and Blood Diseases

Lymphoma

Purpura, Thrombocytopenic, Idiopathic

Purpura

Purpura, Thrombocytopenic

Hemostatic Disorders

Blood Coagulation Disorders

Hemorrhage

Skin Manifestations

Thrombotic Microangiopathies

Thrombocytopenia

Blood Platelet Disorders

Cytopenia

Hemorrhagic Disorders

Autoimmune Diseases

Lymphosarcoma

Immune Thrombocytopenia

Idiopathic Thrombocytopenic Purpura

Gastrointestinal Agents

Esomeprazole

Shigeru Yoshida, MD

The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy in patients given triple therapy for Helicobacter pylori eradication with Nexium + amoxicillin (AMPC) + clarithromycin (CAM), or Nexium + AMPC + metronidazole (MNZ) in usual post-marketing use.

Nexium capsules Specific Clinical Experience Investigation concerning Helicobacter pylori eradication

Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation

Nexium Capsules Specific Clinical Experience Investigation Concerning Helicobacter Pylori Eradication

AstraZeneca

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA	NCT03057171	Helicobacter Py... Gastric Ulcer Duodenal Ulcer Stomach Cancer		19 Years -	Yonsei University
Cytokine Gene Polymorphisms in Gastric Diseases	NCT00197470	Gastric Ulcer Duodenal Ulcer Gastric Cancer	IL-1, TNF-alpha...	0 Years -	Hamamatsu University
Cytokine Gene Polymorphisms in Gastric Diseases	NCT00197470	Gastric Ulcer Duodenal Ulcer Gastric Cancer	IL-1, TNF-alpha...	0 Years -	Hamamatsu University
Systems Biology of Gastrointestinal and Related Diseases	NCT05579444	Ulcerative Coli... Crohn Disease Obesity Colon Polyp Eosinophilic Es... GERD Gastro Esophage... Barrett Esophag... Esophageal Canc... Gastritis Gastric Ulcer Duodenal Ulcer Intestinal Meta... Gastric Cancer Lymphocytic Col... Microscopic Col... Celiac Sprue IBS Irritable Bowel... SIBO NAFLD Gallstone Disea...		18 Years -	Viome
Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation	NCT01435525	Gastric Ulcer Duodenal Ulcer Gastric Mucosa-... Lymphoma Idiopa... Early Gastric C...		-	AstraZeneca
Systems Biology of Gastrointestinal and Related Diseases	NCT05579444	Ulcerative Coli... Crohn Disease Obesity Colon Polyp Eosinophilic Es... GERD Gastro Esophage... Barrett Esophag... Esophageal Canc... Gastritis Gastric Ulcer Duodenal Ulcer Intestinal Meta... Gastric Cancer Lymphocytic Col... Microscopic Col... Celiac Sprue IBS Irritable Bowel... SIBO NAFLD Gallstone Disea...		18 Years -	Viome

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