Symptoms and General Pathology

All Conditions

Neoplasms

Rare Diseases

Postoperative Complications

Sarcoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Soft Tissue Sarcoma

Patients will meet with the Registered Dietitian to discuss calorie, protein, and fluid needs.The dietitian will calculate calorie needs.

* Calorie needs will be reduced by 30%.
* Protein needs will be estimated based on 0.8g/kg BW and then reduced by 70%.
* Dietitian will educate participants on electrolytes and fluid intake based on the reduced food intake.

Two nutritional supplements, one from Ensure (Abbott Laboratories, Chicago, IL) and one from Boost (Nestle, Vevey, Switzerland) will be used for 3 days before surgery.

The supplements are the Ensure Pre-Surgery Clear Carbohydrate Drink and the Ensure Original Nutrition Powder. The Original Nutrition Powder will be mixed with 8oz of water, oat milk, or almond milk. The proposed macronutrient profile for the 3 days of caloric restriction (CR) is less than 8% of calories from protein.

Caloric Restriction Diet

Santiago A Lozano-Calderón, MD, PhD

Joseph J Connolly

Santiago A Lozano-Calderón, MD,PhD

This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.

The goal is to decrease the chance of having wound complications after surgery. Caloric Restriction has been found to be a natural modifier of surgical outcomes. Participants will be randomize into the arms Caloric Restriction Diet or Normal Diet.

Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

Effects Of Caloric Restriction On Post-Operative Complications In Sarcoma Patients Treated With Pre-Operative Radiation Therapy

The Musculoskeletal Tumor Society Rating Scale (MSTS) is a clinician-based scoring system that is scored out of 35 points. A higher score indicates better physical function.

The Toronto Extremity Salvage Score (TESS) is a patient-reported scoring system that is scored out of 100 points. A higher score indicates better physical function.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT	NCT02792270	Tumor Surgery	Caloric Restric...	18 Years -	Massachusetts General Hospital
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT	NCT02792270	Tumor Surgery	Caloric Restric...	18 Years -	Massachusetts General Hospital

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