Behaviors and Mental Disorders

All Conditions

Symptoms and General Pathology

Depression

Pain, Postoperative

Anxiety Disorders

Depressive Disorder

Pain

Psychotropic Drugs

All Drugs and Chemicals

Analgesics

Central Nervous System Depressants

Antiemetics

Gastrointestinal Agents

Esketamine

Hydromorphone

Tropisetron

Analgesics, Opioid

Narcotics

Antidepressive Agents

After the operation, 5 mg esketamine was injected intravenously for postoperative analgesia. PCIA formula: hydromorphone 6mg + esketamine 45mg + tropisetron 10mg into 0.9% sodium chloride injection 100ml, the first dose is 20ug/kg , Background dose 2ug/kg/h, single dose 4ug/kg/time

After the operation, esketamine 2.5mg was injected intravenously for postoperative analgesia. PCIA formula: hydromorphone 6mg + esketamine 22.5mg + tropisetron 10mg into 0.9% sodium chloride injection 100ml, the first dose is 20ug/ kg, background dose 2ug/kg/h, single dose 4ug/kg/time

PCIA formula: 6mg of hydromorphone + 10mg of tropisetron into 100ml of 0.9% sodium chloride injection, the first dose is 20ug/kg, the background dose is 2ug/kg/h, and the single dose is 4ug/kg/time.

By adding different doses of esketamine to the postoperative analgesic pump, and the control group without adding this drug to observe the postoperative pain, anxiety and depression indicators of the surgical patients

High-dose Esketamine hydrochloride+Hydromorphone

Low-dose Esketamine hydrochloride+Hydromorphone

Min Yan, Doctor

Although the acute and chronic postoperative pain of surgical patients has gradually been paid attention to, it has not yet been better resolved.and, the incidence of anxiety and depression in cancer patients is constantly increasing，The new analgesic anesthetic esketamine hydrochloride was launched in China last year，however, in the domestic and foreign literature, there are still few reports of esketamine hydrochloride in postoperative analgesia, and most of them are retrospective and small samples.This study aims to investigate whether esketamine has advantages over traditional opioids in terms of postoperative analgesia, anxiety and depression in cancer patients.

The Effect of Esketamine on Patients Undergoing Tumor Surgery

Effects of Esketamine on Postoperative Pain, Anxiety and Depression in Patients Undergoing Tumor Surgery

Nausea, vomiting, lethargy, mental symptoms, etc.

PCIA usage（ml）, PCIA compressions（frequency）, remedial analgesia measures（Name and dosage of intravenous analgesics）

Ramsay sedation score（The score is 1-6 points, the higher the score, the higher the degree of sedation, the ideal sedation score is 2 points）

Hamilton Anxiety Scale（There are a total of 14 options. Each item is divided into 0-4 points according to the degree, and the score is 0-56 points. The total score is ≥29 points, which may be severe anxiety; ≥21 points, there must be obvious anxiety; ≥14 points, there must be Anxiety; more than 7 points, there may be anxiety; if less than 7, there are no anxiety symptoms.）

Hamilton Depression Scale（There are a total of 17 options, and each item is divided into 0-4 points or 0-2 points according to the degree. The total score is less than 7 points: normal; the total score is 7\~17 points: there may be depression; the total score is 17\~24 points : There must be depression; total score\> 24 points: severe depression）

Sleep quality（Self-assessment by the patient, the score is 1-5 points, the higher the score, the better the sleep）

Chronic pain conversion rate（Follow-up one month after surgery, if there are still pain symptoms, it is chronic pain）

Second Affiliated Hospital, School of Medicine, Zhejiang University

Neoplasms

Rare Diseases

Postoperative Complications

Sarcoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Soft Tissue Sarcoma

Patients will meet with the Registered Dietitian to discuss calorie, protein, and fluid needs.The dietitian will calculate calorie needs.

* Calorie needs will be reduced by 30%.
* Protein needs will be estimated based on 0.8g/kg BW and then reduced by 70%.
* Dietitian will educate participants on electrolytes and fluid intake based on the reduced food intake.

Two nutritional supplements, one from Ensure (Abbott Laboratories, Chicago, IL) and one from Boost (Nestle, Vevey, Switzerland) will be used for 3 days before surgery.

The supplements are the Ensure Pre-Surgery Clear Carbohydrate Drink and the Ensure Original Nutrition Powder. The Original Nutrition Powder will be mixed with 8oz of water, oat milk, or almond milk. The proposed macronutrient profile for the 3 days of caloric restriction (CR) is less than 8% of calories from protein.

Caloric Restriction Diet

Santiago A Lozano-Calderón, MD, PhD

Joseph J Connolly

Santiago A Lozano-Calderón, MD,PhD

This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.

The goal is to decrease the chance of having wound complications after surgery. Caloric Restriction has been found to be a natural modifier of surgical outcomes. Participants will be randomize into the arms Caloric Restriction Diet or Normal Diet.

Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

Effects Of Caloric Restriction On Post-Operative Complications In Sarcoma Patients Treated With Pre-Operative Radiation Therapy

The Musculoskeletal Tumor Society Rating Scale (MSTS) is a clinician-based scoring system that is scored out of 35 points. A higher score indicates better physical function.

The Toronto Extremity Salvage Score (TESS) is a patient-reported scoring system that is scored out of 100 points. A higher score indicates better physical function.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Esketamine on Patients Undergoing Tumor Surgery	NCT04613869	Tumor Surgery	High-dose Esket... Low-dose Esketa... Hydromorphone	18 Years - 65 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
The Effect of Esketamine on Patients Undergoing Tumor Surgery	NCT04613869	Tumor Surgery	High-dose Esket... Low-dose Esketa... Hydromorphone	18 Years - 65 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT	NCT02792270	Tumor Surgery	Caloric Restric...	18 Years -	Massachusetts General Hospital
The Effect of Esketamine on Patients Undergoing Tumor Surgery	NCT04613869	Tumor Surgery	High-dose Esket... Low-dose Esketa... Hydromorphone	18 Years - 65 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT	NCT02792270	Tumor Surgery	Caloric Restric...	18 Years -	Massachusetts General Hospital

Spots Global Cancer Trial Database for tumor surgery