Infections

All Conditions

Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

Symptoms and General Pathology

Rare Diseases

Pancreatic Neoplasms

Communicable Diseases

Surgical Wound Infection

Pancreatic Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Endocrine System Diseases

Pancreatic Cancer

Central Nervous System Depressants

All Drugs and Chemicals

Anti-Infective Agents

Anesthetics

Tazobactam

Piperacillin

Piperacillin, Tazobactam Drug Combination

Anti-Bacterial Agents

Cefotaxime

Cefoxitin

Antibiotics, Antitubercular

beta-Lactamase Inhibitors

Enzyme Inhibitors

Participants will receive one dose of cefoxitin within 1 hour of incision time, redosed every 2-4 hours in the operating room until closure of the incision, and discontinued within 24 hours after anesthesia end time.

Participants will receive one dose of piperacillin-tazobactam within 1 hour of incision time, redosed every 2-4 hours in the operating room until closure of the incision, and discontinued within 24 hours after anesthesia end time.

Piperacillin-tazobactam

Michael D'Angelica, MD

The purpose of this study is to figure out which commonly used antibiotic, cefoxitin or piperacillin-tazobactam, is better at decreasing the rate of surgical site infections after pancreatoduodenectomy.

Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?

A Phase III Multicenter, Open Label Randomized Controlled Trial of Cefoxitin Versus Piperacillin-Tazobactam as Surgical Antibiotic Prophylaxis in Patients Undergoing Pancreatoduodenectomy

To compare the effectiveness of cefoxitin, a second generation cephalosporin (Cohort 1), with piperacillin-tazobactam, a broad-spectrum penicillin (Cohort 2), as surgical antibiotic prophylaxis in decreasing the overall rate of postoperative SSIs in patients undergoing PD. The primary endpoint, overall SSI rate, is defined as superficial incisional SSI, deep incisional SSI, or organ/space SSI within the first 30 days after the operation, as defined according to the ACS NSQIP data collection operations manual.

Indiana University

Massachusetts General Hospital

Thomas Jefferson University

Washington University School of Medicine

Advocate Illinois Masonic Medical Center

Baptist Memorial Health Care Corporation

Baylor Scott and White Health

The Cleveland Clinic

Emory University

Fox Chase Cancer Center

Gundersen Lutheran Medical Center

Hackensack Meridian Health

Hamilton Health Sciences Center

Intermountain Health Care, Inc.

Jersey Shore Medical Center (Hackensack Meridian)

Johns Hopkins University

Montefiore Medical Center/Albert Einstein College of Medicine

North Shore University HealthSystem

Milton S. Hershey Medical Center

Rhode Island Hospital

Stony Brook Medicine

Sunnybrook Health Sciences Centre, Canada

Temple University

The Ohio State University Wexner Medical Center

The Ottowa Hospital/University of Ottowa

University of California, Davis

University of Chicago

University of Iowa

University of Texas Southwestern Medical Center

University of Utah

University of Wisconsin, Madison

Providence Health & Services

Albany Medical College

Northwestern University

Universtiy of Mississippi Medical Center

Mount Sinai Hospital, New York

Brody School of Medicine at East Carolina University

Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for cefoxitin

Every month we try and update this database with for cefoxitin cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for cefoxitin

Every month we try and update this database with for cefoxitin cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for cefoxitin cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.