Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Syndrome

Polycystic Ovary Syndrome

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Anticoagulants

All Drugs and Chemicals

Anti-Infective Agents

Respiratory System Agents

Reproductive Control Agents

Other Dietary Supplements

Amino Acids

Citric Acid

Sodium Citrate

Acetylcysteine

N-monoacetylcystine

Clomiphene

Enclomiphene

Zuclomiphene

Estrogens

Estrogen Antagonists

Estrogen Receptor Antagonists

Hormones

Hormone Antagonists

Selective Estrogen Receptor Modulators

Estrogen Receptor Modulators

Antiviral Agents

Expectorants

Antioxidants

Protective Agents

Antidotes

Citrate

Cysteine

N-acetyl-cysteine + Clomiphene citrate + LOD

N-acetyl-cysteine + Clomiphene citrate + Laparoscopic ovarian drilling

N-acetyl-cysteine

Clomiphene citrate + Laparoscopic ovarian drilling

Clomiphene citrate

This prospective randomized placebo-controlled double blind clinical trial will conducted in Ain Shams University maternity Hospital including 120 women diagnosed with clomiphene citrate resistant polycystic ovary syndrome. After laparoscopic ovarian drilling, they will be randomized to either receiving 50 mg oral clomiphene citrate twice daily and oral NAC 1,200 mg/day for 5 days starting from cycle day 2 to cycle day 6 (group 1 = 60 patients) or clomiphene citrate only (group 2 = 60 patients). The primary outcome will be biochemical pregnancy rate, secondary outcomes include Clinical pregnancy rate, ovulation rate, live birth rate, number of follicles ≥ 18 mm and endometrial thickness at triggering ovulation, mid- luteal sub-endometrial blood flow indices, and incidence of side effects.

NAC in CC Resistant PCOS After LOD

N-acetyl-cysteine in Clomiphene Citrate Resistant Polycystic Ovary Syndrome After Laparoscopic Ovarian Drilling: A Randomized Controlled Trial

Ain Shams University

Hypoglycemic Agents

Micronutrients

Hematinics

Vitamins

Metformin

Insulin

Insulin, Globin Zinc

Tocopherols

Vitamin E

Tocotrienols

alpha-Tocopherol

Liver Extracts

Biguanides

Trace Elements

Tocopherol

Tocotrienol

Vitamin E is sold as a dietary supplement, either by itself or incorporated into a multivitamin product. it also has anti-oxidant effect

vitamin E

Metformin is in the biguanide class. It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. It is also used in the treatment of polycystic ovary syndrome (PCOS)

is a medication used to treat infertility in women who do not ovulate

Clomiphene Citrate

This study evaluate the addition of Vit E to clomiphene citrate in the treatment of poly cystic ovary.Half the patients will receive both Vit E and clomiphene citrate the other half will receive clomiphene citrate only.

Clomiphene and vit E each used in treatment of pco but they do so by different mechanisms.

Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.

Vit E is used in treatment of pco due its anti-oxidant effect.

prospective randomized controlled open label study

Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate

Evaluation of the Clinical Outcome of Vitamin E as Adjuvant Therapy in Patients With Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Follicles measure more than 18 mm will be considered mature follicles.

Misr University for Science and Technology

pharmacist

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
NAC in CC Resistant PCOS After LOD	NCT02775734	Clomiphene Citr...	N-acetyl-cystei... Clomiphene citr...	18 Years - 35 Years	Ain Shams University
NAC in CC Resistant PCOS After LOD	NCT02775734	Clomiphene Citr...	N-acetyl-cystei... Clomiphene citr...	18 Years - 35 Years	Ain Shams University
Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate	NCT03674385	Clomiphene Citr...	vitamin E Metformin Clomiphene Citr...	18 Years - 39 Years	Ain Shams University

Spots Global Cancer Trial Database for clomiphene citrate resistant polycystic ovary syndrome