Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Esophageal Neoplasms

Ischemia

Anastomotic Leak

Esophageal Cancer

Preoperative ischemic conditioning before esophagectomy

Collecting data from the medical record:

* Gastroepiploic artery diameter before and after ischaemic preconditioning
* Postoperative mortality
* Complications related to embolisation and surgery
* Length of stay in intensive care unit and total length of hospital stay

Collecting data from the medical record

Rémi GRANGE, MD

Sylvain GRANGE, MD

Rémi Grange, MD

Sylvain Grange, MD

Zoé Sahut, resident

This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery. Two groups were included : a surgery-alone group (control group) and a PreopAE group (study group) treated with an embolization procedure before esophagectomy. Collected data included patient characteristics, embolization procedure details, surgical outcomes, and postoperative complications.

The primary outcome was the efficacy of preoperative ischemic conditioning in preventing anastomotic leakage, assessed through CT scans. Secondary outcomes included analyzing safety of ischemic gastric conditioning, hypertrophy of the gastroepiploic artery in embolized patients and comparing hospital stay length and postoperative mortality.

Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning

Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning : a Retrospective Monocentric Comparative Study

Radiological confirmation by thoracoabdominal CT scan with oral contrast showing dehiscence of the oesophagastric anastomosis will be sought.

Dehiscence confirmed by the surgeon during a repeat operation will be sought.

Endoscopic confirmation of an anastomotic leak will be sought.

Safety of ischaemic gastric filling will be analysed on the basis of imaging and data recordings.

Hypertrophy of the gastroepiploic artery in embolized patients will be analysed on the basis of imaging and data recordings.

Hospital stay length will be analysed on the basis of data recordings.

Postoperative mortality will be analysed on the basis of data recordings.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning	NCT06312839	Esophageal Canc...	Collecting data...	18 Years -	Centre Hospitalier Universitaire de Saint Etienne
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning	NCT06312839	Esophageal Canc...	Collecting data...	18 Years -	Centre Hospitalier Universitaire de Saint Etienne
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning	NCT06312839	Esophageal Canc...	Collecting data...	18 Years -	Centre Hospitalier Universitaire de Saint Etienne

Spots Global Cancer Trial Database for collecting data from the medical record