Nutritional and Metabolic Diseases

All Conditions

Symptoms and General Pathology

Wasting Syndrome

Cachexia

Syndrome

Weight Loss

Body Weight

Body Weight Changes

Thinness

Metabolic Diseases

Nutrition Disorders

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

All Drugs and Chemicals

Ibuprofen

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Cyclooxygenase Inhibitors

Enzyme Inhibitors

standard care plus multimodal intervention consisting of nutritional supplements and advice, home-based self-assisted exercise program, and anti-inflammatory medication (ibuprofen)

standard care

nutritional supplements and advice

home-based self-assisted exercise program

Stein Kaasa, MD PhD

Marie Fallon, MD PhD

Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment.

There is an urgency for improving management, but there is no consensus on the optimal treatment for cancer cachexia. Several single therapies for cancer cachexia have been examined in clinical trials, with disappointing overall results. As multiple factors are responsible for the development of cachexia, it has been argued that optimal cachexia interventions should target all components: multimodal therapy for a multimodal problem.

The overall aim of this study is to early prevent the development of cachexia rather than treatment late in the disease trajectory. From a patient perspective a short term effect will be to improve physical and psychological function, to reduce symptom burden and to improve survival. In other words live a longer and better life during and after chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of weight and muscle loss, and improved physical activity and quality of life.

Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

A Randomised, Open-label Trial of a Multimodal Intervention (Exercise, Nutrition and Antiinflammatory Medication) Plus Standard Care Versus Standard Care Alone to Prevent/Attenuate Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

St. Olavs Hospital

Oslo University Hospital

Cantonal Hospital of St. Gallen

Ottawa Regional Cancer Centre

Jewish General Hospital

Cross Cancer Institute

The Beatson West of Scotland Cancer Centre

Queen Margaret Hospital, Dunfermline

Cancer Research UK Edinburgh Centre

Malteser Krankenhaus Seliger Gerhardt

Tumor Biology Center Freiburg

Tumor Zentrum Aarau

Chelsea and Westminster NHS Foundation Trust

Cedars-Sinai Medical Center

Guy's and St Thomas' NHS Foundation Trust

NHS Forth Valley

Norwegian University of Science and Technology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy	NCT02330926	Cachexia Neoplasms	standard care nutritional sup... home-based self... Ibuprofen	18 Years -	Norwegian University of Science and Technology
Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy	NCT02330926	Cachexia Neoplasms	standard care nutritional sup... home-based self... Ibuprofen	18 Years -	Norwegian University of Science and Technology

Spots Global Cancer Trial Database for combined modality treatment