The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Official Title: A Randomised, Open-label Trial of a Multimodal Intervention (Exercise, Nutrition and Antiinflammatory Medication) Plus Standard Care Versus Standard Care Alone to Prevent/Attenuate Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Study ID: NCT02330926
Brief Summary: Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. There is an urgency for improving management, but there is no consensus on the optimal treatment for cancer cachexia. Several single therapies for cancer cachexia have been examined in clinical trials, with disappointing overall results. As multiple factors are responsible for the development of cachexia, it has been argued that optimal cachexia interventions should target all components: multimodal therapy for a multimodal problem. The overall aim of this study is to early prevent the development of cachexia rather than treatment late in the disease trajectory. From a patient perspective a short term effect will be to improve physical and psychological function, to reduce symptom burden and to improve survival. In other words live a longer and better life during and after chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of weight and muscle loss, and improved physical activity and quality of life.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Cedars-Sinai Medical Center, Los Angeles, California, United States
CA4 Brampton Civic Hospital, Brampton, , Canada
Cross Cancer Insitute, Edmonton, , Canada
Jewish General Hospital, Montréal, , Canada
Ottawa Regional Cancer Centre, Ottawa, , Canada
Universitätsklinikum Bonn, Bonn, , Germany
Oslo University Hospital, Oslo, , Norway
St Olavs Hospital, Trondheim, , Norway
Tumor Zentrum, Aarau, , Switzerland
Cantonal Hospital, St. Gallen, , Switzerland
NHS Forth Valley, Larbert, Falkirk, United Kingdom
Queen Margaret Hospital, Dunfermline, Fife, United Kingdom
Llandough Hospital, Cardiff, , United Kingdom
Edinburgh Cancer Centre, Edinburgh, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Chelsea and Westminister Hospital NHS, London, , United Kingdom
Guys and St Thomas, London, , United Kingdom
Name: Stein Kaasa, MD PhD
Affiliation: European Palliative Care Research Centre (PRC), Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim, Norway
Role: STUDY_DIRECTOR
Name: Marie Fallon, MD PhD
Affiliation: Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
Role: STUDY_DIRECTOR