Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Syndrome

Polycystic Ovary Syndrome

Ovarian Cysts

Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Hypoglycemic Agents

All Drugs and Chemicals

Natriuretic Agents

Reproductive Control Agents

Flavonoid

Metformin

Drospirenone

Ethinyl Estradiol

Estradiol 17 beta-cypionate

Estradiol 3-benzoate

Estradiol

Polyestradiol phosphate

Contraceptive Agents

Contraceptives, Oral

Contraceptives, Oral, Combined

Contraceptive Agents, Female

Hesperidin

Metformin (Glucophage ® 500 tablets twice daily)+ Combined oral contraceptive (standard therapy) (Yassmin ® film-coated tablets 3 mg of drospirenone and 0.03 mg of ethinyl estradiol once daily daily)

Diosmin /Hesperidin (Daflon two tablets 500 mg daily)+ Combined oral contraceptive((Yassmin ® film-coated tablets 3 mg of drospirenone and 0.03 mg of ethinyl estradiol once daily daily)

Diosmin /Hesperidin (Daflon two tablets 500 mg daily) +Metformin (Glucophage ® 500 tablets twice daily) + Combined oral contraceptive combination (Yassmin ® film-coated tablets 3 mg of drospirenone and 0.03 mg of ethinyl estradiol once daily daily

Daflon; two film coated tablets 500 mg daily

Daflon

Yassmin ® film-coated tablets 3 mg of drospirenone and 0.03 mg of ethinyl estradiol once daily daily

Combined oral contraceptive

Polycystic ovary syndrome (PCOS) is one of the most prevalent disorders worldwide. Insulin resistance, inflammation and disturbance in sex hormone levels are the main contributing factors of this disease.The majority of studies addressing the status of chronic low-grade inflammation in PCOS have focused on the measurement of C-reactive protein (CRP) followed by stimulation of interleukin 6 (IL-6) and tumor necrosis factor (TNF-alpha).

Daflon 500 mg tablets (containing 90% of diosmin and 10% of hesperidin) is used in patients to treat varicose veins, venous ulcers, hemorrhoids and lymphatic insufficiency. It has anti-diabetic, anti-inflammatory, microcirculatory, and antioxidant effects. So the aim of the work is to investigate the effect of Diosmin/Hesperidin in the management of PCOS through evaluation of Oxidative stress and inflammation, improvement of signs and symptoms through patients' follow-up, improvement of PCOS status by sonography and hormonal levels, measuring of anti-diabetic effect by measuring, fasting insulin, HOMA-IR and measuring the improvement of patient's quality of life by using the women health questionnaire (WHQ).

Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome

Effect of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome

Improvement of PCOS status by improvement of the inflammatory markers (IL-6)

Improvement of glycemic index by measuring fasting Insulin, HOMA-IR

Improvement of PCOS status by improvement of signs and symptoms, hormone levels

Improvement of patient's quality of life by using the women health questionnaire (WHQ)

Ain Shams University

Assistant lecturer

Rare Diseases

Ovarian Neoplasms

Endocrine Gland Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Ovarian Cancer

Progestins

Progesterone

Hormones

Hormone Antagonists

Estrogens

trial the effect of placebo in treatment of functional ovarian cyst

trial of the effectiveness of cocs in the treatment of functional ovarian cyst

comparison between the effect of progesterone in the treatment of functional ovarian cyst with the effect of cocs

effect of cocs in treatment of ovarian cysts

Combined Oral Contraceptive

effect of progestin in treatment of ovarian cystn

Progestin

salah mohamed rasheed, professor

mamdouh elsemary aaied, dr

comparison between cocs and progesterone only containing pills in treatment of fuctional ovarian cyst

Ovarian cyst is a blister-like sac, which is formed on the surface of ovary during or after ovulation . Most of them are made in reproductive age and are harmless ; these cysts do not cause any symptom and are resolved without treatment , but sometimes they cause health problems that require special attention, and even may lead to infertility. Normal function of ovary is the periodic release of ovums and the production of the steroid hormones of estradiol and progesterone . Both activities are integrated in the continuous repetitive process of follicle maturation, ovulation, and corpus luteum formation and regression. Mature follicle is ruptured and releases ovum during ovulation and corpus luteum is produced from empty follicle if pregnancy does not occur corpus luteum is regressed, due to the absence of hCG (human chorionic gonadotropin). Sometimes this procedure does not happen normally, which results in the formation of ovarian cysts Therefore, functional ovarian cysts are different from ovarian growths induced by other pathological problems most of them regress spontaneously in two or three cycles , but if a cyst gets large, it can twist, be ruptured, or bleed and become very painful .

A functional type of ovarian cyst forms because of slight changes in the way of making or releasing an ovum by the ovary . There are two types of such cysts:

1. The follicular cyst, which occurs when the sac on ovary does not release an egg and the sac swells up with fluid
2. The luteal cyst, which is formed when the sac releases an egg and then reseals and fills with fluid

Most functional ovarian cysts are asymptomatic , the larger the cyst, the more likely the symptom. The symptoms are pain or aching in lower abdomen, menstrual irregularity, vaginal bleeding, dyspareunia, etc.; sometimes the cyst is ruptured and causes peritoneal irritation with presentations such as nausea and vomiting or sudden onset of pain, hemorrhagic cyst, intra-abdominal bleeding, and emergency conditions . Some other manifestations such as nausea and vomiting may be felt before the occurrence of such events . Regular pelvic examination is recommended for some patients with the history of such cysts; they also may need regular sonography . Oral contraceptive pills (OCPs) are prescribed by some physician to shrink the cyst, if it is persistent and makes discomfort . Although it seems that they are not effective enough compared with close observation, and even some researchers reported no benefits for OCPs, some others prescribed them before any surgical practices ; therefore, the current study aimed at evaluating this issue. For this purpose, some patients who referred to a private clinic were selected in order to compare the effect of OCPs with close observation in the clinical management of functional ovarian cysts. dyspareunia, or the cysts may be found accidentally on voluntary sonography without any symptoms.

Treat of Functional Ovarian Cysts by Compare Between Cocs and Progesterone Only Pills

Treatment of Functional Ovarian Cyst Randomised Clinical Trial

rate of treatment of combined oral contraceptive pills in functional ovarian cyst compared with cases who will receive progesterone only pills

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome	NCT06083935	Poly Cystic Ova...	Daflon Combined oral c... Metformin	18 Years - 40 Years	Ain Shams University
Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome	NCT06083935	Poly Cystic Ova...	Daflon Combined oral c... Metformin	18 Years - 40 Years	Ain Shams University
Treat of Functional Ovarian Cysts by Compare Between Cocs and Progesterone Only Pills	NCT05244811	Ovarian Neoplas...	Combined Oral C... Progestin	18 Years - 48 Years	Sohag University

Spots Global Cancer Trial Database for combined oral contraceptive