Symptoms and General Pathology

All Conditions

Neoplasms

Nervous System Diseases

Rare Diseases

Hemorrhage

Meningioma

Neoplasms, Nerve Tissue

Neoplasms by Histologic Type

Neoplasms, Vascular Tissue

Meningeal Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Coagulants

All Drugs and Chemicals

Tranexamic Acid

Infusion with 20mg/kg tranexamic acid and 5mg/kg/h tranexamic acid.

Infusion with 20mg/kg tranexamic acid and same volume 0.9% saline.

Infusion with same volume of 0.9% saline.

The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by 5mg/kg/h tranexamic acid infusion.

Continous infusion

The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by same volume of 0.9% saline.

Single infusion

The 0.9% saline is administered with the same volume at the same speed as the other group.

Placebo

Shu Li, M.D.

Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.

Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection

Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial

Estimated intra-operative blood loss is assessed as following formula:collected blood volume in the suction canister (mL) - the volume of flushing (mL) + the volume from gauze tampon (mL).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection	NCT05230381	Tranexamic Acid Intraoperative ... Meningioma	Continous infus... Single infusion Placebo	18 Years - 65 Years	Beijing Tiantan Hospital
Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection	NCT05230381	Tranexamic Acid Intraoperative ... Meningioma	Continous infus... Single infusion Placebo	18 Years - 65 Years	Beijing Tiantan Hospital
Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection	NCT05230381	Tranexamic Acid Intraoperative ... Meningioma	Continous infus... Single infusion Placebo	18 Years - 65 Years	Beijing Tiantan Hospital
Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection	NCT05230381	Tranexamic Acid Intraoperative ... Meningioma	Continous infus... Single infusion Placebo	18 Years - 65 Years	Beijing Tiantan Hospital

Spots Global Cancer Trial Database for continous infusion