Infections

Skin and Connective Tissue Diseases

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Warts

Condylomata Acuminata

Communicable Diseases

Papillomavirus Infections

Virus Diseases

DNA Virus Infections

Skin Diseases

Skin Diseases, Viral

Tumor Virus Infections

Skin Diseases, Infectious

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

Genital Diseases

Urogenital Diseases

Dermatologic Agents

All Drugs and Chemicals

Aminolevulinic Acid

Photosensitizing Agents

The painless photodynamic therapy（P-PDT）group underwent narrow-band light-emitting diode (LED) irradiation (630 nm; 400 J/cm2) after applying 20% 5-aminolevulinic acid（ALA）cream for 30min. A repeat treatment was administered once weekly for a maximum of 3 weeks.

The conventional photodynamic therapy(C-PDT) group underwent narrow-band light-emitting diode (LED) irradiation (630 nm; 100 J/cm2) after applying 20% 5-aminolevulinic acid cream for 3h.A repeat treatment was administered once weekly for a maximum of 3 weeks.

Aminolevulinic acid photodynamic therapy

Haiyan Zhang, MD

Yunfeng Zhang, MD

Xiuli Wang, PhD,MD

Xiuli Wang, PhD, MD

This study is being done to compare a new, continuous illumination and short Incubation time regimen of aminolevulinic acid photodynamic therapy（ALA-PDT) to a conventional regimen for treatment of small genital warts. The hypothesis is that the continuous illumination approach will be less or even no painful, but equally efficacious, as the old regimen.

Evaluator assesses photographs without prior knowledge of intervention

Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Small Genital Warts

Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Small Genital Warts：a Randomized, Open-label Trial

The clearance rate of Genital Warts will be measured at one week after the last treatment.

The pain will be assessed using Visual Analogue Scale（VAS) with a score range of 0-10. The higher the score, the greater the pain, with 0 being no pain and 10 being the most unbearable pain. Pain will be measured at different time points during and after every treatment ，including immediately, 1st min, 3rd min, 5th min, 7th min, 10th min , and every 10 min to the end of treatment and 2nd h, 12th h, 24th h and 48th h after treatment.

The recurrence rates will be measured at 3 months after the last treatment.

Shanghai Dermatology Hospital

Director, Clinical Professor

Gland and Hormone Related Diseases

Neoplasms

Thyroid Diseases

Thyroid Neoplasms

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Complement System Proteins

Conventional operation group,Thyroidectomy was performed first, and central compartment dissection was performed. This is a routine procedure.

central neck dissection first group,after FNA confirmed of thyroid carcinoma, the central compartment neck dissection was carried out before thyroidectomy , finally complement of central compartment neck dissection.

Conventional operation ,Thyroidectomy was performed first, and central compartment dissection was performed. This is a routine procedure

Conventional

central neck dissection first ,after FNA confirmed of thyroid carcinoma, the central compartment neck dissection was carried out before thyroidectomy , finally complement of central compartment neck dissection.

central neck dissection first

wen-xin zhao, md

bo wang, md

Wen-xin ZHAO, MD

Bo WANG, MD

In accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.In the course of clinical work, if the patient can achieve R0 resection, most of the patients do not need iodine-131 treatment,Therefore, there is no need to continue total thyroidectomy.To evaluate the practicable, thoroughness and Clinical value of bilateral central compartment dissection while preserve contrary thyroid glands.

In accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.In the course of clinical work, if the patient can achieve R0 resection, most of the patients do not need iodine-131 treatment,Therefore, there is no need to continue total thyroidectomy.This study assesses new procedures by adjusting the sequence of procedures. complications and the thoroughness of the operation were evaluated, thus Clinical value of bilateral central compartment dissection with preserve contrary thyroid glands were ananlyed.

Evaluation of Central Compartment Dissection Without Thyroidectomy

To Evaluate the Practicable, Thoroughness and Clinical Value of Bilateral Central Compartment Dissection While Preserve Contrary Thyroid Glands

The weight of the central compartment tissue.

the number of recurrent laryngeal nerve palsy

Fujian Medical University

Clinical professor

Blood and Lymph Conditions

Rare Diseases

Leukemia

Leukemia, Myeloid

Leukemia, Myeloid, Acute

Neoplasms by Histologic Type

Hematologic Diseases

Myeloid Leukemia

Acute Myeloid Leukemia

Acute Non Lymphoblastic Leukemia

Acute Graft Versus Host Disease

Conventional haematological management of patients and Comprehensive Geriatric assessment (CGA) at diagnosis followed by interventions according to disabilities detected and planned monthly follow up by a nurse practitioner during 6 months.

Conventional haematological management of patients

Each month after randomization, a nurse practitioner will systematically review the intervention plan.

In case of hospitalisation, the nurse will go and meet the patient and his care giver to check each point of the intervention plan. If an action has not been done, a new proposal will be made to the patient. If the patient is at home or in institution, the nurse practitioner will call the patient and /or his care giver for the same purpose

WITH Comprehensive Geriatric assessment

Dominique GENRE, MD

Agnès BOYER CHAMMARD, MD

Aude CHARBONNIER, MD

Acute myeloid leukaemia (AML) is a disease of the elderly, with a median age at diagnosis of 65. A poor outcome in this population has been well established, with very short overall survival (OS) and disease free survival (DFS).There are numerous bad prognostic factors related to the disease itself or to the patient's medical condition.

This study will evaluate the impact of a Comprehensive Geriatric assessment (CGA) performed at diagnosis with planned interventions according to disabilities and monthly follow-up by a nurse practitioner during 6 months on functional status of older cancer patients treated for Acute myeloid leukaemia. Functional status will be assessed with the Lawson Instrumental Activities of Daily Living (IADL) scale at diagnosis and 6 months after randomisation.

Program of Evaluation and Geriatric Intervention on the Functional Status, Quality of the Life, and Survival

Randomized Study Comparing the Interest of a Program of Evaluation and Geriatric Intervention on the Functional Status, Quality of the Life, and Survival of Elderly Patients With Acute Myeloid Leukaemia. MLSP/IPC 2009-003

The functional status is evaluated with KATZ INDEX : BASIC ACTIVITIES OF DAILY LIVING (ADL) and Older American Resources and Services, Instrumental Activities of Daily Living (IADL) mesured at diagnosis and 6 month after inclusion.

mesured by the Mini Nutritional Assessment Short Form (mini MNA-SF)

estimated by a Quality of Life Questionnaire including 30 items (QLQ-C30)

Institut Paoli-Calmettes

Digestive System Diseases

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Herbal and Botanical

Cola

All patients with operable colon cancer who will undergo laparoscopic conventional colectomy

All patients with operable colon cancer who will undergo laparoscopic complete mesocolic excision

Laparoscopic colectomy with only lymph node dissection up to level 2 lymph nodes D2.

laparoscopic conventional colectomy

Laparoscopic colectomy with lymphovascular dissection from level 3 lymph nodes or more D3.

laparoscopic complete mesocolic excision

Ahmed E Ahmed, Professor

Mena Z Helmy, Ass prof.

Mostafa F Mohammed, Ass lecturer

The investigators will assess and compare Surgical, pathological and oncological outcomes between two laparoscopic procedures conventional colectomy versus complete mesocolic excision for operable colon cancer cases in Upper Egypt

Colon cancer is considered a huge clinical surgical burden accounting for 10% of cancer cases and deaths all over the world with consideration that surgery and adjuvant chemotherapy(if indicated) are the main lines of treatment .

When Werner Hohenberger and colleagues described complete mesocolic excision (CME) in 2009; resection along the embryological and lymphovascular planes with appropriate resection margins, they did it for years before describing it with suggestion of improved disease outcomes and overall survival compared to the conventional colectomy (CC).

The principles of CME were described after the significant improvement of rectal adenocarcinoma surgical outcomes with establishment of total mesorectal excision (TME) in which tumor resection is associated with dissection of mesorectal fascial embryologic and lymphovascular planes.

CME includes the same principles of the CC with maximizing lymph node dissection level into (D3 extended lymphadenectomy instead of D1 and D2 in conventional colectomy) and central vascular ligation (CVL) of the main feeding vessel(s) at their origin, with suggested improved disease-free and overall survival with suggested superior pathological and oncological results in the specimen.

Some surgeons consider that CME; with D3 extended lymphadenectomy and CVL is the optimal or standard surgical method in primary cancer colon based on suggested reduced local recurrence and improved disease-free and overall survival.

Although CME has a theoretical advantages and promising early results, it is not widely adopted as the standard in some areas. CME is technically more demanding than CC and suggested to be associated with more intraoperative visceral injuries and non-surgical complications and many doubts persist about safety and efficacy of the procedure.

The questions of interest and research, should CME be regarded as the optimal procedure for colon cancer cases? And also another question; is conventional colectomy suboptimal?

Comparison Between Results of 2 Laparoscopic Surgical Procedures in Operable Colon Cancer Cases in Upper Egypt

Surgical, Pathological and Oncological Outcomes of Laparoscopic Conventional Colectomy Versus Complete Mesocolic Excision for Operable Colon Cancer Cases in Upper Egypt

It is not yet known if there will be a plan to make IPD available.

Histopathological examination of the resected colon with lymph node status and number

Amount in cubic cm and nature of it with its management

Yes/No with Reporting the postoperative complications; according to the Clavien-Dindo Grading System

Reporting operative time with measurements in minutes

Yes/No with measurement in Cubic Cm and how managed

According to primary tumor, regional nodes, metastasis (TNM) staging system

Reporting Yes/No with amount in cm3 and management

Carcinoembryonic antigen (CEA) level by ng/mL

Type of anastomosis (intra- or extracorporeal)

cecum, appendix, ascending colon, hepatic flexure or at splenic flexure, transverse and descending colon and sigmoid colon

Yes/No Cardiopulmonary complications type and how managed

Sohag University

assistant lecturer of general surgery

Neoplasm Metastasis

Lymphatic Metastasis

Neoplastic Processes

Patients will get the standard of care in the Netherlands with the addition of surgical navigation

Patients will get the standard of care in the Netherlands

Patients will be operated with assistance of a navigation system

Surgical navigation

Patients will be operated using the conventional technique

Image-guided navigation surgery allows for full utilization of pre-operative imaging during surgery, and has the potential of reducing both irradical resections and morbidity. In this study we will randomize patients which will undergo an abdominal lymph node dissection in order to evaluate the actual technical and clinical benefit of navigation

In the study patients will be randomized between the use of a surgical navigation system or not. The operation itself will be performed according to current clinical practice, and the navigation system will be used for better localization and orientation during the procedure.

Navigated Abdominal Lymph Node Dissections

Targeted Abdominal Lymph nodE Dissections Randomized for Surgical NavigaTion (TALENT)

Failed procedure is defined as: presence of any residual target lymph node on follow-up imaging

time from having the surgical field prepared for lymph node localization to actual removal of the lymph node, overall surgical time,

The Netherlands Cancer Institute

Adenocarcinoma

Prostatic Neoplasms

Carcinoma

Neoplasms, Glandular and Epithelial

One phase technique (IMRT or 3D-CRT): radiotherapy to the prostate + pelvic lymphnodes

two-phase technique (IMRT or 3D-CRT): 1) whole pelvis including the prostate and regional lymph nodes; 2) boost to the prostate

Centres using IMRT will use the dose painting technique to treat the prostate + proximal 1-cm SV to 6800 cGy in 25 fractions while the pelvic lymph nodes will receive 4500 cGy in 25 fractions. For patients with T3b, the whole SV is to be treated to 6800 cGy. Institutions using 3D-CRT will deliver the required dose to the pelvic volume (including pelvic lymph nodes and boost volume) - 4500 cGy - and a concomitant boost to the prostate and proximal 1-cm (or the whole SV if involved) SV to 6800 cGy.

hypofractionation

The first phase: whole pelvis including the prostate and regional lymph nodes treated with 4400 cGy in 22 fractions.

The second phase: prostate + proximal 1-cm SV treated with 3200 cGy in 16 fractions.

For patients with T3b, the whole SV is to be treated to 7600 cGy.

conventional

Tamim Niazi, MD

In North America, around a quarter a million men are diagnosed with prostate cancer every year, and about 31,000 patients will die of their disease each year. Like other western countries, the incidence in Canada has increased due to an aging population and prostate specific antigen (PSA) screening. This has led to a significant demand on cancer care services for these patients. Prostate cancer patient with high risk features are more often treated with external beam radiation therapy (EBRT) plus two to three years of hormonal manipulation (luteinizing hormone-releasing hormone \[LHRH\] agonist). The most common radiation dose treatment for these patients is 74-78 Gy in 37-39 daily fractions of 180-200 cGy for a treatment length of 7.5 weeks. This fraction size is believed to offer the best balance between desired tumour kill and unwanted normal tissue injury. Larger fraction sizes of more than 250 cGy (hypofractionation) are usually avoided for curative therapy because late reacting normal tissues. However prostate cancer cells have a unique radiobiology characteristic that suggests that hypofractionated radiotherapy is more efficient at prostate tumour killing than standard fractionation is, and will produce equivalent tumour control with a lower total dose and a shorter overall treatment time. Improved target localization techniques and conformal radiation therapy technology have allowed for dose escalation and hypofractionated radiation delivery in these circumstances with minimal or no increased toxicities.

This trial is designed to determine whether high risk prostate cancer patients can be safely treated with a dose escalation hypofractionated radiation therapy in 5 weeks as opposed to the usual 7-8 weeks. These patients will be randomized to either the usual 76 Gy in 38 fractions or 68 Gy in 25 fractions. 3D-Conformal Radiotherapy (3D-CRT) or Intensity Modulated Radiotherapy (IMRT) will be used to deliver the required radiation dose. Patients will also receive 28 months of androgen deprivation therapy (LHRH agonist). The primary outcome of the study is the acute and delayed toxicity and the secondary outcomes include biochemical failure, prostate specific mortality rate, bone metastases free survival, the prognostic and predictive value of several biological variables: presence of the PTEN deletion; expression of FoxP3 gene variants, topoisomerase 2α and cancer testis antigens; expression of X chromosome-linked micro-RNAs; presence of TMRSS2-ERG gene fusion and quality of life. It is planned to recruit 250 patients to this study.

Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate

Phase III Study of Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate, Using 3D-CRT or Intensity-Modulated Radiotherapy

primary outcome is the acute and delayed genito-urinary and gastrointestinal toxicity differences (at or before 90 days for the acute and 90-180 days and after for the delayed toxicity) in high risk prostate cancer patients treated with the hypofractionation vs standard of care regimen using 3D-CRT or IMRT.

To measure freedom from biochemical failure at 3 and 5 years.

To measure disease specific and overall survival at 5 years

To prospectively correlate dose-volume histograms of the rectum and bladder by studying wall and whole organ volumes to the development of GI and GU toxicity.

Sir Mortimer B. Davis - Jewish General Hospital

Radiation Oncologist

Breast Neoplasms

Breast Diseases

conventional (2D) imaging plus tomosynthesis (3D) imaging first then tomosynthesis alone 1 month later.

tomosynthesis (3D) imaging alone first then conventional (2D) imaging plus tomosyntheis 1 month later.

The mean glandular radiation dose for each image will be approximately 145 millirads (mrad) for a standard size breast (4.2 cm compressed breast thickness).

Tomosynthesis

conventional (2D) imaging (standard mammography)

Elizabeth A Rafferty, MD

The primary hypothesis to be tested is:

The detection of breast cancer will be increased with tomosynthesis (3D) imaging

The purpose of this study is to determine if: 1 the detection of breast cancer will be increased with conventional (2D) imaging plus tomosynthesis (3D) imaging, or 2. if the the detection of breast cancer will be increased with tomosynthesis (3D) imaging alone.

Breast Cancer Detection: Comparison of Breast Tomosynthesis and Conventional Mammography

Sensitivity is the number of true positives (TP) divided by the sum of TP and false negatives (FN):

Sensitivity = TP / (TP+FN)

Hologic, Inc.

Massachusetts General Hospital

Vice Chairman, Radiology Research

PI left institution in 2012; Data remaining did not include outcome measure and adverse event data. Institution contacted PI on numerous occasions. PI also does not have data.

496 participants enrolled overall, but no information available to distinguish study arms:

1. Conventional+Tomosynthesis First Then Tomo alone 1 mo. Later (number enrolled in arm is unknown).
2. Tomosynthesis alone First Then Conventional+Tomo 1 mo. Later (number enrolled in arm is unknown).

All Study Participants

All study participants in both arms. 496 enrolled and 426 completed study, but no information available to distinguish study arms.

Age, Categorical

Sex: Female, Male

United States

Region of Enrollment

496 participants enrolled overall, but no information available to distinguish study arms:

1. Conventional+Tomosynthesis First Then Tomo alone 1 mo. Later (number of participants enrolled in arm is unknown).
2. Tomosynthesis alone First Then Conventional+Tomo 1 mo. Later (number of participants enrolled in arm is unknown).

PI left institution in 2012; Data remaining did not include outcome measure and adverse event data. Institution contacted PI on numerous occasions. PI also does not have data.

Thomas J. Brady, MD

Tomosynthesis: The mean glandular radiation dose for each image will be approximately 145 millirads (mrad) for a standard size breast (4.2 cm compressed breast thickness).

Conventional: conventional (2D) imaging (standard mammography)

Conventional + Tomosynthesis First Then Tomo Alone 1 mo. Later

Tomosynthesis Alone First Then Conventional+Tomo 1 mo. Later

Detection of Breast Cancer (Sensitivity)

Overall Study

Death

Seroma

Inflammation

The skin flaps will not undergo further treatment in this group.

The skin flaps will be sutured on to the pectoral muscle after having performed the mastectomy.

ARTISS tissue glue will be applied to the skin flaps after mastectomy

Application of ARTISS Glue to skin flaps after mastectomy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Small Genital Warts	NCT03948321	Genital Warts	Aminolevulinic ...	18 Years -	Shanghai Dermatology Hospital
Evaluation of Central Compartment Dissection Without Thyroidectomy	NCT03454464	Thyroidectomy Thyroid Cancer Central Compart...	Conventional central neck di...	18 Years - 70 Years	Fujian Medical University
Program of Evaluation and Geriatric Intervention on the Functional Status, Quality of the Life, and Survival	NCT01188330	Acute Myeloid L...	WITH Comprehens... Conventional	70 Years -	Institut Paoli-Calmettes
Comparison Between Results of 2 Laparoscopic Surgical Procedures in Operable Colon Cancer Cases in Upper Egypt	NCT05421702	Colon Cancer St... Colon Cancer St...	laparoscopic co... laparoscopic co...	-	Sohag University
Navigated Abdominal Lymph Node Dissections	NCT05867095	Image-guide Sur... Lymph Node Meta...	Surgical naviga... Conventional	18 Years -	The Netherlands Cancer Institute
Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate	NCT01444820	Prostate Cancer	hypofractionati... conventional	18 Years -	Sir Mortimer B. Davis - Jewish General Hospital
Navigated Abdominal Lymph Node Dissections	NCT05867095	Image-guide Sur... Lymph Node Meta...	Surgical naviga... Conventional	18 Years -	The Netherlands Cancer Institute
Breast Cancer Detection: Comparison of Breast Tomosynthesis and Conventional Mammography	NCT01669148	Breast Cancer	Tomosynthesis Conventional	35 Years -	Massachusetts General Hospital
Seroma Reduction After Mastectomy	NCT03305757	Seroma Aspiration Breast Cancer	Artiss vicryl sutures Conventional	18 Years -	Zuyderland Medisch Centrum
Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Small Genital Warts	NCT03948321	Genital Warts	Aminolevulinic ...	18 Years -	Shanghai Dermatology Hospital

Spots Global Cancer Trial Database for conventional

Every month we try and update this database with for conventional cancer trials from around the world to help patients and their families find trials that might be right for them.
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