Neoplasms

Digestive System Diseases

All Conditions

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Herbal and Botanical

All Drugs and Chemicals

Cola

Da Vinci Robotic Surgery

The purpose of this study is to compare the clinical data of patients with colon cancer who received robotic or laparoscopic surgery, and to compare the short-term and long-term effects of robotic surgery in the treatment of colon cancer. To verify the safety and effectiveness of the corresponding surgical methods, and provide better guidance for the following clinical practice.

Prospective Registration Study of Robtic Laparoscopy Versus Laparoscopy Assisted Colon Cancer Surgery

first exhaust, defecation time, restoring liquid diet, hospitalization days, etc.

The First Hospital of Jilin University

Professor

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Urinary Bladder Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Participants will be randomized to receiving ECD after scheduled Robotic Assisted Radical Cystectomy (RARC).

Participants will be randomized to receiving ICD after scheduled Robotic Assisted Radical Cystectomy (RARC).

Extra-corporeal urinary diversion, provided as part of standard of care, will have the ureters sutured into the ileal conduit by hand.

Extracorporeal Urinary Diversion

Intracorporal Urinary Diversion, provided as part of standard of care, will have the ureters sutured into the ileal conduit using the Da Vinci robot.

Intracorporal Urinary Diversion

Da Vinci Robot

Mark L Gonzalgo, MD, PhD

Intracorporeal urinary diversion (ICD) provides superior postoperative outcomes compared to extracorporeal urinary diversion (ECD). The investigators' hypothesis that ICD may provide clinical benefit is based on principles of less bowel and ureteral handling, superior operating room workflow, less exposure to the external environment, and optimal visualization with ICD while utilizing a smaller incision compared to ECD. ICD should have less bowel-related complications, lower pain scores allowing patients to be discharged from the hospital sooner and regain functional independence more quickly.

Intracorporeal vs Extracorporeal Urinary Diversion After Robot Assisted Radical Cystectomy

Randomized Clinical Trial of Intracorporeal vs Extracorporeal Urinary Diversion After Robot Assisted Radical Cystectomy

Major complication rate at 90-days from RARC + urinary diversion using the modified Clavien-Dindo grading system. Major complication is defined as Clavien-Dindo Grade ≥ 3.

Any complication rates at 90-days from RARC + urinary diversion, using the modified Clavien-Dindo grading system as low grade (1-2) or high grade (3-5).

Length of hospital stay for study participants undergoing ECD versus ICD urinary diversion post-RARC, as recorded at hospital discharge.

Rate of readmission to hospital at 90 days post-RARC followed by ECD or ICD urinary diversion.

Rate of return to the operating room within 90 days after RARC followed by ICD or ECD Urinary Diversion.

Rate of mortality (death) at 90 days in study participants

Rate of bowel-specific complications in study participants (including incidence of mechanical bowel obstruction, anastomotic leaks, and surgical site infections) and post operative pain. Bowel-specific complications will be assessed using the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) version 4.

Rate of functional independence recovery as measured by patient-reported scores on the Activities of Daily Living (ADL) questionnaire. For the ADL, the total score ranges from 0 to 6, with the higher scores indicating functional improvement and lower scores indicating functional deterioration.

Rate of functional independence recovery as measured by an aggregate of patient-reported scores on the Instrumental Activities of Daily Living (IADL) questionnaire. For the IADL, the total score ranges from 0 to 8, with higher scores indicating functional functional improvement and lower scores indicating functional deterioration.

The Hand Grip Strength Test measures the amount of static force that a participant's hand can squeeze around a dynamometer. The test is measured in kilograms.

The TUG test times participants as they rise from a standard chair, walk 3 meters, turn, walk back and sit again. The test is measured in seconds.

HRQoL measured by patient scores on the Short Form 8 (SF-8) Health Survey. The SF-8 is a questionnaire consisting of 8-items and two component summary scores: Physical component summary (PCS) and mental component summary (MCS). They are scored by weighting each score to a norm-based scoring model. The total scores will be reported as a percentile with higher score indicating better health-related quality of life.

HRQoL measured by patient scores on the Functional Assessment of Cancer Therapy-Vanderbilt Cystectomy Index (FACT-VCI) questionnaire. The FACT-VCI is a condition-specific instrument for patients undergoing radical cystectomy (RC) and urinary diversion (UD) for bladder cancer. The questionnaire consists of 44 items scored on a range from 0 ("Not at all") to 4 ("Very Much"), resulting in an ordinal Likert scale, with higher scores indicating a better HRQoL. The FACT-VCI measures quality of life across five domains: Physical wellbeing, social/family wellbeing, emotional wellbeing, functional wellbeing and an additional concerns subscale.

University of Miami

Professor of Clinical

Rectal Neoplasms

Rectal Diseases

This group is consisted of 56 cases performed using the Micro Hand S robot and da Vinci robot by one single surgeon in low anterior resection for rectal cancer

This group is consisted of 56 cases performed using the da Vinci robot by one single surgeon in low anterior resection for rectal cancer

The surgeries are performed with the Micro Hand S robot and da Vinci robot

Micro Hand S robot and da Vinci robot

The surgeries are performed with the da Vinci robot

da Vinci robot

Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013. This new MIS robot had been authorized to enter the clinical trial stage by the Ethics Committee of the Third Xiangya Hospital at Central South University. The Micro Hand S robot is safe and feasible in the preliminary study. However, the learning curve in low anterior resection for rectal resection with the Micro Hand S robot are unclear and whether the two surgical robots (Micro Hand S and da Vinci) shared a similar learning curve and the two robot can be trained simultaneously. Therefore, the investigators conduct this retrospective study to focus on this concern.

The Micro Hand S robor has been appiled in low anterior resection for rectal cancer. The safey and feasibility has been evaluated. However, the learning curve of this procedure is unclear. Specially,whether the two surgical robots (Micro Hand S and da Vinci) shared a similar learning curve and the two robot can be trained simultaneously are unclear.Therefore, this srudy is conducted to evaluate the learning curve of the two robots in low anterior resection.

Evaluation of the Learning Curve in Low Anterior Resection for Rectal Resection With the Two Surgical Robots

Accelerated Learning Curve in Low Anterior Resection for Rectal Resection, a New Surgical Robot Micro Hand S Versus da Vinci, Can be Attained Simultaneously: a Single Center Experience

It was defined the cumulative sum plot of the consloe time in the chronological order.

It was defined the cumulative sum plot of the docking time in the chronological order.

It was defined as what type of procedure was pferformed, for example, low anterior, abdominal perineal resection

It was defined as the duration from skin incision to skin closure

The console time was defined the fime that the surgeon performed the surgeon console.

The docking time was the time from moving robotic instruments in the surgical field to setting robotic arms into the port sites

Conversion was defined as any change in strategy to open surgery

It was defined as the amount of blood in the whole surgical time

It was defined as the length of hospital stay

It was defined as ileostomy which diverted the feces to to ensure anastomotic healing

It was defined as the number of all the lymph nodes for each patient

Surgical failure was defined as the presence of one or more of the following four parameters: conversion, the positive surgical margins, severe postoperative complications, the number of harvested lymph nodes less than 12

It was defined as the pathological stage of the tumor according the TNM classification

It was defined as the longitudinal diameter of the tumor

It was defined as the distance betwen the distal resection margin and the low margin of the tumor

It was defined as whether the distal and circumferential resection margins was involved the tumor cell under microscope

The quality of the speciman was graded according to the protocol proposed by Quirke

It was defined as the adverse events after operation and the complications were classfied according to the Clavien-Dindo (C-D) classification

It was defined as the tumor was again found in the pelvic cavity

It was defined as the duration between the operation and date of the tumor recurrence

The Third Xiangya Hospital of Central South University

Gland and Hormone Related Diseases

Eye Diseases

Immune System Diseases

Thyroid Diseases

Graves Disease

Thyroid Nodule

Thyroiditis

Goiter

Thyroid Neoplasms

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Endocrine System Diseases

Exophthalmos

Orbital Diseases

Hyperthyroidism

Autoimmune Diseases

Patients in this arm will have a thyroidectomy performed using a robot-assisted endoscopic technique.

Patients in this arm will have a thyroidectomy using an open surgical technique.

Patients will have a thyroidectomy via a robot-assisted (da Vinci robot) endoscopic (subclavical entry)surgical technique.

Robot-assisted thyroidectomy

Patients will have a conventional (non-endoscopic) thyroidectomy using an open surgical technique

Open thyroidectomy

Benjamin Lallemant, MD

The main objective is to compare 12 month complication rates between a new surgical method for thyroidectomy (robot-assisted endoscopic thyroidectomy via a sub-clavical approach) and open thyroidectomy.

Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy

Randomized Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy

The per or post-operative occurrence of at least one of the following: postoperative hemorrhage requiring reintervention; cervical infection requiring antibiotics and/or surgical intervention; transient or persistent laryngeal paralysis; transient or persistent hypoparathyroidy (calcemia \< 1.9 µmol/l). Transiient means \< than and persistent means \>= 12 months.

Length of incision in the open group, and sum of incision lengths in the robot group.

Patient satisfaction as regards the incision scar measured using a visual analog scale from 0.0 to 10.0.

For patients in the robot arm: presence/absence of conversion to open technique.

Time in minutes necessary to prep the operating room

Presence/absence of per-operative complications

Length of hospitalization in days required after thyroidectomy

Thyroglobulinemia at 12 months - Thryoglobulinemia as baseline

Calcemia on Day 1 - Calcemia at inclusion

Calcemia at the control visit (days 7 to 15) - Calcemia at inclusion

Calcemia at 12 months - Calcemia at inclusion

Phosphoremia at 1 day postop - Phosphoremia at inclusion

Phosphoremia at control visit (days 7 to 15) - Phosphoremia at inclusion

Phosphoremia at 12 months - Phosphoremia at inclusion

Parathormonemia on Day 1 post-op - parathormonemia at inclusion

Parathormonemia at control visit (days 7 to 15) - parathormonemia at inclusion

Parathormonemia at 12 months - parathormonemia at inclusion

Visual Analog Scale for pain (0.0 to 10.0)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prospective Registration Study of Robtic Laparoscopy Versus Laparoscopy Assisted Colon Cancer Surgery	NCT04843189	Da Vinci Robot Colon Cancer Surgery	Da Vinci Roboti...	18 Years - 80 Years	The First Hospital of Jilin University
Intracorporeal vs Extracorporeal Urinary Diversion After Robot Assisted Radical Cystectomy	NCT03469362	Bladder Cancer	Extracorporeal ... Intracorporal U... Da Vinci Robot	18 Years - 99 Years	University of Miami
Evaluation of the Learning Curve in Low Anterior Resection for Rectal Resection With the Two Surgical Robots	NCT04855448	Rectal Cancer	Micro Hand S ro... da Vinci robot	18 Years - 80 Years	The Third Xiangya Hospital of Central South University
Prospective Registration Study of Robtic Laparoscopy Versus Laparoscopy Assisted Colon Cancer Surgery	NCT04843189	Da Vinci Robot Colon Cancer Surgery	Da Vinci Roboti...	18 Years - 80 Years	The First Hospital of Jilin University
Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy	NCT01320813	Thyroid Nodule Goiter Thyroiditis Graves Disease	Robot-assisted ... Open thyroidect...	18 Years - 85 Years	Centre Hospitalier Universitaire de Nīmes

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