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Irinotecan

Capecitabine

Dendrobium huoshanense Suppository: 1.7g rectal administration per day for 5 weeks

Concurrent Chemoradiotherapy:

Radiation: 50Gy/25Fx; Capecitabine: 625mg/m2 bid Monday-Friday per week; Irinotecan: 80mg/m2 (UGT1A1\*28 and \*6: 6/6+GG) or 65mg/m2 (UGT1A1\*28 and \*6 ：6/7+GG or 6/6+GA) or 50mg/m2 （UGT1A1\*28 and \*6 ：7/7+GG or 6/6+AA or 6/7+GA）.

Placebo: 1.7g rectal administration per day for 5 weeks

Concurrent Chemoradiotherapy:

Radiation: 50Gy/25Fx; Capecitabine: 625mg/m2 bid Monday-Friday per week; Irinotecan: 80mg/m2 (UGT1A1\*28 and \*6: 6/6+GG) or 65mg/m2 (UGT1A1\*28 and \*6 ：6/7+GG or 6/6+GA) or 50mg/m2 （UGT1A1\*28 and \*6 ：7/7+GG or 6/6+AA or 6/7+GA）.

1.7g rectal administration per day for 5 weeks

Dendrobium Huoshanense Suppository

Ji Zhu, MD

JI Zhu, MD

To evaluates the role of Dendrobium Huoshanense Suppository for radiation proctitis in locally advanced rectal cancer treated by capecitabine and irinotecan based neoadjuvant chemoradiation.

Dendrobium Huoshanense Suppository in Rectal Cancer

A Multicenter Randomized Controlled Stage III Clinical Study of Dendrobium Huoshanense Suppository in Locally Advanced Rectal Cancer Patients Treated by Neoadjuvant Chemoradiotherapy

Zhejiang Cancer Hospital

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital

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