Neoplasms

Digestive System Diseases

All Conditions

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Health Professionals Follow-up Study: a prospective cohort of male health professionals

Nurses' Health Study: a prospective cohort of female registered nurses

No intervention will be used. This is an observational study with dietary patterns as main exposure

Observed dietary pattern

Fred Tabung, PhD, MSHP

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in American men and women with ≥130,000 new cases each year. Several dietary patterns have been associated with CRC risk but underlying mechanisms are not fully understood. Researchers thus propose to integrate dietary patterns and metabolomics data to comprehensively investigate biological pathways linking dietary patterns and CRC risk.

Several dietary patterns have been associated with colorectal cancer (CRC) risk but underlying mechanisms are not fully understood. Also, evidence is lacking on the consistency of dietary guidelines for overall health and CRC prevention given that it is not feasible to have an optimal diet for every disease. Furthermore, metabolomic profiling has not been widely assessed with respect to CRC risk. Metabolomics is uniquely suited to assess metabolic responses to dietary stimuli, given that it is situated downstream to all the other "omics". Building on prior work in hypothesis-driven dietary patterns and CRC prevention, the researchers seek to fill these knowledge gaps by proposing to: 1) use a standardized methodology to compare the best diet for overall health with the best diet for CRC prevention, and further determine if any associations of dietary patterns with CRC prevention are mediated by mechanisms involving inflammation and insulin; 2) determine metabolites that may mediate the association of dietary intake with CRC risk. The researchers will utilize two large prospective cohort studies, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS), in which dietary and nondietary data have been collected every 2 to 4 years among 173,230 women and men over the last ≥30 years, with ≥3,400 CRC cases and ≥43,800 all-cause deaths. This integrated interrogation of dietary patterns and metabolomics data will inform the design of guidelines for healthful lifestyles that are optimized for CRC prevention.

Plasma samples to analyze for inflammatory, insulin response biomarkers and metabololites

Dietary Patterns, Metabolomics and Colorectal Cancer Risk

Dietary Patterns, Metabolomics and Colorectal Cancer Risk and Mortality in the Nurses' Health Study and Health Professionals Follow-Up Study

The incidence of these major chronic diseases will be examined as surrogate for overall health

Incident death of any cause (as surrogate for overall health)

Ohio State University Comprehensive Cancer Center

Principal Investigator

Nutritional and Metabolic Diseases

Metabolic Diseases

50 subjects, adults aged over 18 years, voluntarly participating in this observational study

This is an observational study. The control group (omnivours) will be compared with all otgher groups

This is an observational study

Esther Molina Montes

Noelia M Rodriguez Martin

Mireia Obon Santacana

Pilar Amiano

Esther Molina Montes, Doctor

Esther Molina-Montes

Maria Dolores Ruiz Lopez

Reyes Artacho

Belen Garcia-Villanova

Vito Verardo

Maria Jose Sanchez Perez

Miguel Rodriguez Barranco

Beatriz Sarria

Noelia M Rodriguez-Martin

Justo J Pedroche Jimenez

Ana L Lemus-Conejo

Rocio M Toscano Sanchez

Raquel Cumeras

Noelia M Rodriguez

This projects aims to characterize dietary habits and nutrition quality of pro-vegetarian diets as compared to omnivorous diets. It also aims to stablish gut microbial and metabolit profiles of this dietary pattern, in order to elucidate the role of plant-based diets in cancer prevention and treatment.

Plant-based foods (fruits, vegetables, cereals, nuts and seeds, legumes, and vegetable oils) are the main source of fiber and other bioactive compounds in the diet. Plant-based diets are therefore assumed to prevent mortality and the ocurrence of chronic diseases including cancer. However, evidence on this issue is still scarce, and the mechanisms and drivers of their potential health benefits are also only partially known.

The main objectices of this project are:

1. To develop and validate dietary assessment methods for the vegetarian population
2. To assess dietary habits and consumer beliefs of vegetarians with respect to omnivores, considering different types of vegetarian diets
3. To identify a gut microbiota signature related to plant-based diets from subgroups of subjects following a plant-based diet foods (vegans, lacto-vegetarians, ..., and pro-vegetarians) and omnivorous subjects (non-plant-based diets), from stool metagenomic sequencing.
4. To relate this signature with metabolites present in faeces (related to the presence of certain microbial species) and in urine to improve the predictive capacity of the microbial signature of vegetable diets.
5. Validate the signature using independent study populations, and including colorectal and breast cancer survivors as another study target.

Pro-Vegetarian Diets, Microbial/Metabolite Profiles and Cancer

Characterizacion of Pro-VEgetarian Diets: Diet Quality and Nutrition, MIcrobial/Metabolite Profiles and Implications in CAncer (MIVECA Study)

Dietary habits will be taken by an online specific Food Frequency Questionnaire (FFQ) for Spanish population, including novel vegetarian foods to evaluate vegetarian food consumption. The data analysis will be taken at baseline outcome.

To validated dietary assessment method, two 24-Hour-Recalls in two non-consecutive days will be used, as well as the analysis of specific vegetarian diet metabolites in urine and stool samples using Ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS). The data analysis will be taken at baseline. We have estimated that 200 subjects will be sufficient to detect, with a 95% confidence and power of 90%, correlation coefficients greater than rho=0.2.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Dietary Patterns, Metabolomics and Colorectal Cancer Risk	NCT03364582	Colorectal Canc... Mortality	Observed dietar...	30 Years -	Ohio State University Comprehensive Cancer Center
Pro-Vegetarian Diets, Microbial/Metabolite Profiles and Cancer	NCT05621122	Dietary Habits Food Habits Nutrition, Heal... Cancer Metabolic Disea...	This is an obse...	18 Years -	Universidad de Granada
Pro-Vegetarian Diets, Microbial/Metabolite Profiles and Cancer	NCT05621122	Dietary Habits Food Habits Nutrition, Heal... Cancer Metabolic Disea...	This is an obse...	18 Years -	Universidad de Granada

Spots Global Cancer Trial Database for dietary patterns