Heart and Blood Diseases

All Conditions

Neoplasms

Mouth and Tooth Diseases

Rare Diseases

Hypotension

Head and Neck Neoplasms

Mouth Neoplasms

Vascular Diseases

Mouth Diseases

Stomatognathic Diseases

Oral Cancer

Lip and Oral Cavity Cancer

Vasoconstrictor Agents

Respiratory System Agents

All Drugs and Chemicals

Cardiotonic Agents

Vasodilator Agents

Epinephrine

Norepinephrine

Dobutamine

Racepinephrine

Epinephryl borate

Sympathomimetics

Dopexamine

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

Adrenergic beta-Agonists

Bronchodilator Agents

Anti-Asthmatic Agents

Mydriatics

Protective Agents

Dopamine

Dopamine Agonists

Dopamine Agents

Epinephrine, Norepinephrine, Dobutamine, Dopexamine

0.2mcg/kg/min maximum infusion; to increase mean arterial pressure by 30mmHg

Maximum infusion of 0.2mcg/kg/min, to increase mean arterial pressure by 30mmHg

Maximum infusion rate of 8mcg/kg/min to increase mean arterial pressure by 30mmHg

Maximum infusion rate of 5mcg/kg/min to increase mean arterial pressure by 30mmHg

Stephen R Watt-Smith, FDSRCS, MD

Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.

The optimal sympathomimetic drug to support blood pressure without adverse vasoconstriction of free flap circulation remains unknown. This study examined the effects of four agents (epinephrine, norepinephrine, dobutamine and dopexamine) on free flaps following resection of head and neck cancer.

Twenty five patients were recruited to the study. Each patient received an infusion of the four drugs in a random order with an intervening washout period between drugs, at four infusion rates. Continuous free flap skin blood flow monitoring was performed using laser Doppler velocimetry, with a second sensor on normal skin acting as a control. Global cardiovascular variables were monitored using the LiDCO Rapid pulse contour analysis system.

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

An Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery: A Randomised Study

Oxford University Hospitals NHS Trust

Mr SR Watt-Smith

Primary fluid admission: 1 mL/bodyweight kg/ hour crystalloid. If Pulse pressure variation is lower than 10%; 250 mL/15 min of colloid or crystalloid is administered depending on randomization.

Fluid management

Norepinephrine is administered if Mean arterial pressure drops below 65 mmHg. Mean arterial pressure must be maintained above 65 mmHg. Norepinephrine is titrated accordingly.

Dobutamine is administered if Cardiac index drops below 2.5 L/min/m2. Cardiac index must be maintained above 2.5 L/min/m2. Dobutamine is titrated accordingly.

Maintaining satisfactory tissue perfusion is an essential of success during reconstructive free flap surgery following malign oral cavity tumours. Intra- and postoperative goal-directed fluid therapy is an appropriate tool for that. Continuous cardiac output monitoring based fluid loading (complemented with vasopressor and/or inotropes if necessary) might be superior to conventional, central venous and arterial pressure monitoring in terms of morbidity, complications, optimal fluid balance and days spent in hospital. However, there is no data describing the effects of goal-directed fluid therapy (crystalloid or colloid) on microcirculation of free flaps implanted in the oral cavity during the post-operative period. The aim of this study is to observe the effects of continuous macrohaemodynamic monitoring based, goal-directed fluid therapy on microcirculation of forearm flaps during the perioperative period.

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Microcirculation in Free Flap Reconstruction of Intraoral Tumours.

Department of Oral and Maxillofacial Surgery, University of Szeged

Institute of Surgical Research, University of Szeged

Szeged University

head of department

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery	NCT01418118	Oral Cancer Head and Neck C... Free Flap Hypotension	Epinephrine Norepinephrine Dobutamine Dopexamine	17 Years -	Oxford University Hospitals NHS Trust
Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps	NCT03288051	Optimal Tissue ...	Fluid managemen... Norepinephrine Dobutamine	18 Years -	Szeged University

Spots Global Cancer Trial Database for dobutamine

Every month we try and update this database with for dobutamine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for dobutamine

Every month we try and update this database with for dobutamine cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for dobutamine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.