Neoplasms

All Conditions

Head and Neck Neoplasms

Vasoconstrictor Agents

All Drugs and Chemicals

Cardiotonic Agents

Norepinephrine

Dopamine

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

Sympathomimetics

Dopamine Agents

Protective Agents

vasopressor dosage individually titred according to the mean arterial pressure

no medication

Vasopressors may be needed after head and neck microvascular reconstructions to maintain sufficient mean arterial pressure. This is crucial for the flap survival. The study hypothesis is that norepinephrine and dopamine used as vasopressors do not affect flap tissue oxygen level and microdialysate metabolites.

The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements

Tampere University Hospital

MD, PhD, Senior Consultant, Associate Chief

Heart and Blood Diseases

Nervous System Diseases

Rare Diseases

Pheochromocytoma

Hypertension

Autonomic Nervous System Diseases

Primary Dysautonomias

Paraganglioma

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Paragangliomas 1

Neuroendocrine Tumor

Neuroepithelioma

Respiratory System Agents

Amino Acids

Epinephrine

Racepinephrine

Epinephryl borate

Tyrosine

This study involves sampling blood from both normal volunteers and patients with diseases known or suspected to involve body chemicals called catecholamines. The blood will be used to establish normal values for plasma levels of catecholamines and related neurochemicals; to test for abnormal neurochemical patterns in patients; and to establish a "bank" of DNA from normal volunteers and from patients to be used in future studies about possible alterations of catecholamine-related genes.

Study participants will report to NIH after fasting overnight except for water or noncaloric, noncaffeinated beverages. They must not have taken Tylenol for at least 5 days. Blood will then be drawn. DNA will be extracted and stored in the freezer for future studies.

This project is to allow blood sampling from normal volunteers and patients with dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic systems. The blood is used to establish normal values for plasma levels of catechols and related neurochemicals; test for abnormal neurochemical patterns in patients; and establish a "bank" of DNA samples from normal volunteers and from patients, to be used in future studies about mutations or polymorphisms of catecholamine-related genes.

Blood Sampling for Neurochemical and Genetic Testing

National Institute of Neurological Disorders and Stroke (NINDS)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements	NCT02241083	Head and Neck C...	Dopamine Norepinephrine no medication	-	Tampere University Hospital
The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements	NCT02241083	Head and Neck C...	Dopamine Norepinephrine no medication	-	Tampere University Hospital
Blood Sampling for Neurochemical and Genetic Testing	NCT00001147	Autonomic Nervo... Healthy Hypertension Pheochromocytom...		-	National Institutes of Health Clinical Center (CC)

Spots Global Cancer Trial Database for dopamine

Every month we try and update this database with for dopamine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for dopamine

Every month we try and update this database with for dopamine cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for dopamine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.