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R-MegaCHOP14 x 4 Restaging + R-MAD + MAD + BEAM + ASCT

R-CHOP14 x 4 Restaging + R-MAD + MAD + BEAM + ASCT

R-MegaCHOP14 x 4 Restaging + R-MegaCHOP x 2

Ciclofosfamide

Doxorubicina

Vincristina

Pegfilgrastim

ARA-C

BCNU

VP-16

ASCT

Umberto Vitolo, MD

The purpose of this study is to define an improvement in patients randomized in four different arms:

Arm 1: R-MegaCHOP14x4 + R-MAD + MAD + BEAM + ASCT; Arm 1BIS: R-CHOP14x4 + R-MAD + MAD + BEAM + ASCT; Arm 2: R-MegaCHOP14x4 + R-MegaCHOP14x2; Arm 2BIS: R-CHOP14x4 + R-CHOP14x4; Which are different in dose dense chemotherapy + Rituximab with or without intensified high dose chemoimmunotherapy and support of peripheral autologous stem cells.

Dose Dense Chemotherapy + Rituximab +/-Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cell in Diffuse Large B-Cell Lymphoma

A Randomised Multicentric Phase III Study for the Treatment of Young Patients With High Risk (IPI 2-3) Diffuse Large B-Cell Lymphoma. Dose Dense Chemotherapy + Rituximab +/- Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cells.

Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte

Fondazione Italiana Linfomi - ETS

Umberto Vitolo

Spots Global Cancer Trial Database for doxorubicina

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