Neoplasms

All Conditions

Digestive System Diseases

Carcinoma

Carcinoma, Hepatocellular

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Antineoplastic Agents

All Drugs and Chemicals

Chlorotrianisene

In the group of subjects randomized in this group, the image guidance component of the procedure will be conducted by the acquisition of 3D CT-like images during a trans-hepatic arterial injection of iodinated contrast agent for road mapping the tumor feeding vessels and supplemented by DSA as needed by the operating physician as imaging guidance for planning tumor(s) treatment approach.

In the group of subjects randomized in this group, present standard of care, i.e DSA imaging only will be used by the operating physician to map out the tumor vessels and used for treatment approach. Additional 3D CT-like images will be obtained, but only used if the operator cannot perform adequate planning using DSA alone.

C-arm CT images obtained and supplemented with DSA if needed

C-arm CT + DSA as needed

DSA only

Dr. Rebecca Fahrig

Nishita N. Kothary

Patients will be enrolled based on presence of HCC and eligibility for TACE. They will be randomized to one of two arms for imaging navigation to the optimal catheter location for chemotherapy injection to treat the first (possibly sole) tumor target. The two arms will be: TACE using C-arm CT supplemented by DSA or DSA only (only DSA images will be used for navigation and tumor vessel tracking). Navigation to subsequent treatment targets in all patients will be done with fluoroscopy, CACT, and DSA, as is standard of care at Stanford University Medical Center, and is not part of the study. Vascular complexity, which affects navigation difficulty and thus the need for imaging, will be assessed separately for use in data analysis by two radiologists on a four-point scale.

We hope to learn more about the utility of C-arm CT in patients undergoing TACE for HCC. Data will be evaluated with regards to:

1. Sensitivity and specificity to diagnose additional tumors and its impact on transplantation criteria.
2. The ability to decrease procedural time by aiding navigation through complex arterial anatomy.
3. Impact on radiation dose. Although the patient would receive the radiation during C-arm CT, overall the number of DSA angiograms and fluroscopy may decrease, potentially negating any effect of the additional dose from C-arm CT

Impact of C-arm CT in Patients With HCC Undergoing TACE: Optimal Imaging Guidance

Impact of C-arm CT in Patients With Hepatocellular Carcinoma (HCC) Undergoing Transhepatic Arterial Chemoembolization (TACE): Optimal Imaging Guidance

Dose area product (DAP) is a measure of the entire amount of energy (radiation dose) delivered to the patient by the beam (indicator of stochastic dose)

CD - a measurement of total radiation to the skin (measure of a deterministic dose)

Siemens Healthcare Diagnostics Inc

Stanford University

Assistant Professor

C-arm CT used for the purposes of navigation, supplemented by DSA if needed

C-arm CT + DSA as Needed

DSA Only

C-arm CT in imaging guidance of TACE supplemented by DSA as needed for vessel navigation and tracking

DSA images only used for vessel navigation and tracking

Total

<=18 years

Over 18 years old

Age, Customized

Sex: Female, Male

Only patients completing the study are represented here. The three patients that were excluded by the physician is because the patients disease had progressed by the time of the study

This is an imaging study looking at two different modalities of imaging. There is no long term follow up or A/Es associated with this type of a study

Dr Nishita Kothary

C-arm CT images used for navigational purposes supplemented by DSA if needed

C-arm CT +DSA as Needed

Only DSA imaging used for navigational purposes

Dose Area Product (DAP)

Cumulative Dose (CD), a Measure of Radiation Dose

C-arm CT in imaging guidance of TACE supplemented with DSA as needed for vessel tracking and navigation

Only Digital subtraction images used for vessel tracking and tumor navigation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Impact of C-arm CT in Patients With HCC Undergoing TACE: Optimal Imaging Guidance	NCT00926536	Carcinoma, Hepa...	C-arm CT + DSA ... DSA only	18 Years -	Stanford University
Impact of C-arm CT in Patients With HCC Undergoing TACE: Optimal Imaging Guidance	NCT00926536	Carcinoma, Hepa...	C-arm CT + DSA ... DSA only	18 Years -	Stanford University

Spots Global Cancer Trial Database for dsa only

Every month we try and update this database with for dsa only cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for dsa only

Every month we try and update this database with for dsa only cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for dsa only cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.