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Cachectic patients with pancreatic cancer

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Systemic inflammatory profile: blood sampling. Resting metabolic rate: indirect calorimetry. Physical activity level: accelerometry. Total daily energy expenditure: double-labeled water.

Cachectic patients with non-small cell lung cancer

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Systemic inflammatory profile: blood sampling. Resting metabolic rate: indirect calorimetry. Physical activity level: accelerometry. Total daily energy expenditure: double-labeled water.

Cachectic COPD patients.

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Systemic inflammatory profile: blood sampling. Resting metabolic rate: indirect calorimetry. Physical activity level: accelerometry. Total daily energy expenditure: double-labeled water.

Non-cachectic COPD patients.

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Systemic inflammatory profile: blood sampling. Resting metabolic rate: indirect calorimetry. Physical activity level: accelerometry. Total daily energy expenditure: double-labeled water.

BAT activity: 18F-FDG PET-MRI-imaging. Body composition: DXA scanning, D2O and MRI. Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Systemic inflammatory profile: blood sampling. Resting metabolic rate: indirect calorimetry. Physical activity level: accelerometry. Total daily energy expenditure: double-labeled water.

18F-FDG PET-MRI-imaging

Body composition: DXA scanning, D2O and MRI.

DXA scanning

Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.

Abdominal subcutaneous adipose tissue biopsy

Systemic inflammatory profile: blood sampling.

Blood sampling

Resting metabolic rate: indirect calorimetry.

Indirect calorimetry

Accelerometry

Body composition: DXA scanning, D2O and MRI. Total daily energy expenditure: double-labeled water.

Double-labeled water

Annemie Schols, PhD

To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.

This is a prospective, cross-sectional study to determine BAT activity in cachectic patients with pancreatic or non-small cell lung cancer, and in cachectic patients with chronic obstructive pulmonary disease (COPD), and compare results with healthy individuals and non-cachectic COPD patients, matched for age and BMI.

Brown Adipose Tissue Activity and Energy Metabolism in Cachexia

Brown Adipose Tissue Activity and Energy Metabolism in Cachexia Induced by Cancer or Chronic Disease

The main endpoint of this study is BAT volume and intensity of activity in Standard Uptake Value (SUV) in the presence of cancer cachexia, COPD cachexia, and compared to non-cachectic COPD patients and healthy individuals, as assessed by 18F-fluoro-deoxyglucose (18F-FDG) PET-MRI scanning.

Detailed body composition phenotyping of cachexia by (PET-)MRI to compare with commonly applied clinical measures (D2O and DXA)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia	NCT02500004	Cachexia Neoplasms Pulmonary Disea... Pancreatic Neop...	18F-FDG PET-MRI... DXA scanning Abdominal subcu... Blood sampling Indirect calori... Accelerometry Double-labeled ...	30 Years -	Maastricht University Medical Center
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia	NCT02500004	Cachexia Neoplasms Pulmonary Disea... Pancreatic Neop...	18F-FDG PET-MRI... DXA scanning Abdominal subcu... Blood sampling Indirect calori... Accelerometry Double-labeled ...	30 Years -	Maastricht University Medical Center
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia	NCT02500004	Cachexia Neoplasms Pulmonary Disea... Pancreatic Neop...	18F-FDG PET-MRI... DXA scanning Abdominal subcu... Blood sampling Indirect calori... Accelerometry Double-labeled ...	30 Years -	Maastricht University Medical Center
Brown Adipose Tissue Activity and Energy Metabolism in Cachexia	NCT02500004	Cachexia Neoplasms Pulmonary Disea... Pancreatic Neop...	18F-FDG PET-MRI... DXA scanning Abdominal subcu... Blood sampling Indirect calori... Accelerometry Double-labeled ...	30 Years -	Maastricht University Medical Center

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