Neoplasms

Symptoms and General Pathology

All Conditions

Digestive System Diseases

Neoplasm Metastasis

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Hematinics

All Drugs and Chemicals

Micronutrients

Anti-Infective Agents

Liver Extracts

Iodine

Cadexomer iodine

DCE-CT, also known as perfusion CT, is a functional imaging modality that uses repeated computed tomography imaging after injection of an iodine based contrast agent.

Patients will receive DCE-CT prior to the start of standard of care, Stereotactic Body Radiation Therapy (SBRT), as well as 6 hours post administration of SBRT and 6 weeks post administration of SBRT.

Dynamic Contrast Enhanced Computed Tomography

Moyed Miften, PhD

This is a pilot study that uses a standard of care technique, Stereotactic Body Radiation Therapy (SBRT), in combination with Dynamic Contrast Enhanced Computed Tomography (DCE-CT) to determine if perfusion changes from SBRT of liver cancer may be used for outcome assessment and prediction of prognosis.

Patients will undergo standard of care SBRT while also receiving DCE-CT, also known as perfusion CT, pre-treatment, 6 hours post-treatment and 6 weeks post-treatment.

Each patient will receive the standard of care, with the intervention, DCE-CT perfusion, occurring pre-treatment and post-treatment

Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients

Pilot Study of Dynamic Contrast Enhanced Computed Tomography (DCE-CT) Imaging for the Assessment of Radiation Therapy Outcome for Liver Cancer Patients

Determine the association between the delivered radiation therapy dose distribution and the change in perfusion measurement through K-Trans (extraction-flow product) as shown through DCE-CT imaging.

Determine the association between the delivered radiation therapy dose distribution and the change in perfusion measurement through blood volume as shown through DCE-CT imaging.

Determine the association between the delivered radiation therapy dose distribution and the change in perfusion measurement through blood flow as shown through DCE-CT imaging.

Stratify K-Trans results by age to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify K-Trans results by sex to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify K-Trans results by race to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify K-Trans results by clinical stage at diagnosis to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood volume results age to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood volume results sex to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood volume results race to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood volume results by clinical stage at diagnosis to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood flow results age to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood flow results sex to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood flow results race to determine correlation of DCE-CT imaging results compared to patient demographics

Stratify blood flow results by clinical stage at diagnosis to determine correlation of DCE-CT imaging results compared to patient demographics

National Cancer Institute (NCI)

University of Colorado, Denver

Head and Neck Neoplasms

This group will consist of 15 patients with locally advanced HNSCC of the oral cavity, larynx or hypopharynx presenting with adenopathy ≥ 1 cm where the recommended treatment is surgical resection of the primary malignancy with bilateral neck dissection. These patients will receive a DCE-CT scan of the head and neck prior to surgery.

This group will consist of 15 patients with locally advanced HNSCC with lymph nodes ≥3 cm in which chemoradiotherapy is the primary treatment as per standard of care. This group will be composed of patients with a primary malignancy originating in the nasopharynx, oropharynx, hypopharynx or larynx. Pre-treatment DCE-CT of neck will be obtained. The standard therapy, radiation and chemotherapy, will be administered and the patients will have standard follow up. A post-treatment DCE-CT of neck will be obtained 8-10 weeks after treatment along with standard CT neck.

The neck will be scanned using 120 kVp, 50 mAs, 8 x 5 mm slices at intervals of 2.8 - 3.0 s for 3 min. Contrast (e.g. Visipaque 320) at a dosage of 0.7 ml/kg is injected at 4 ml/s through an antecubital vein after a delay of 6 s from start of scanning.

Dynamic Contrast Enhanced CT scan

David A Palma, MD, MSc, PhD

For patients undergoing treatment for head and neck cancer, this study will use dynamic contrast-enhanced CT scans to try to determine which lymph nodes in the neck contain cancer and require surgical removal.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients	NCT03891654	Liver Cancer	Dynamic Contras...	18 Years - 100 Years	University of Colorado, Denver
Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer	NCT01549379	Head and Neck C...	Dynamic Contras...	18 Years -	Lawson Health Research Institute
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients	NCT03891654	Liver Cancer	Dynamic Contras...	18 Years - 100 Years	University of Colorado, Denver

Spots Global Cancer Trial Database for dynamic contrast enhanced computed tomography