Symptoms and General Pathology

All Conditions

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Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Polyps

Uterine Neoplasms

Pathological Conditions, Anatomical

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

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Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

Oculocerebral Syndrome With Hypopigmentation

Herbal and Botanical

All Drugs and Chemicals

Participants were grouped according to their basic conditions without any intervention.

no intervention It's only observational study. No interventions.

No interventions.

Shi-Peng zhang

qinxiu zhang

Qinxiu Zhang

There are currently no studies evaluating the association between diet and the incidence of endometrial polyps. We aim to evaluate the association to provide more recommendations for the early prevention of endometrial polyps.

The incidence of endometrial polyps is closely related to daily diet and living habits. Due to the excessive use of food additives, the content of some common dietary hormones exceeds the standard, causing irreversible effects on female growth and development.

The daily diet structure is closely related to women's health, and the enrichment of estrogen in common drinks may cause adverse effects such as premature puberty in women, abnormal thyroid function, and changes in uterine structure. Therefore, the researchers conducted a retrospective analysis of patients with endometrial polyps and normal women to compare the associations and differences between daily diet and disease.

Observational Study of the Association Between Food Intake and Endometrial Polyps

A Cross-sectional Observational Study of the Association Between Food Intake and Endometrial Polyps

Readers can access the survey data through a public data platform

Daily dietary intake questionnaire was used to evaluate.Weekly intake of milk tea, coffee, beverage, etc

Sleep, exercise, and other basic information were assessed based on a daily habits questionnaire.

Head of ENT

Progesterone

Progestins

Hormones

Hormone Antagonists

patients who receive a watch-and-wait approach

Treatment consists of 7 days of 25 mg subcutaneous progesterone administered from 18° to 25° day of the menstrual cycle and repeated for 3 cycles

subcutaneous progesterone

Roberta Venturella, MD

Gian Marco Miele, MD

Alberto Vaiarelli, MD

Gabriele Saccone, MD

Antonio Raffone, MD

This prospective randomized study will compare the regression rates of women managed with watch-and-wait approach and of those treated with 3 cycles of luteal 25mg subcutaneous progesterone from 18 to 25 days of menstrual cycle

In premenopause, 25% of endometrial polyps regresses spontaneously in 1 year. According to guidelines, given that most premenopausal polyps are not malignant, there is an option for expectant approach with no surgical intervention. Studies on the efficacy of medical treatments for endometrial polyps are also recommended by gynaecologic societies, with the aim of finding cost-saving not invasive strategies to manage this common pathology. Up to now, nobody has investigated the effect of progestin administration on polyps, but molecular and clinical data suggest that the antiestrogenic effect of this hormone can be exploited to increase and speed-up their regression rate. Our preliminary results on the effect of three months of progesterone demonstrated a regression rate of 47,5% in women treated vs 12,5% in those don't receiving treatment.

Accordingly, in this prospective randomized study we aim to compare the regression rates of women managed with watch-and-wait approach and of those treated with 3 cycles of luteal 25mg subcutaneous progesterone from 18 to 25 days of menstrual cycle

Endometrial Polyps Regression With Progesterone Therapy

Efficacy of Subcutaneous Progesterone in Premenopausal Woman With Endometrial Polyp: a Multicentric Randomized Control Trial

US evidence of normal endometrial line without evidence of polyps

Effect of progesterone on polyps dimensions measured in mm

Correlation between the size of the polyps and the efficacy of progesterone therapy in terms of regression of lesions

Effect of progestogen therapy on symptoms possibly present in patients with endometrial polyps, assessed with PBAC (Pictorial blood loss assesment chart) score.

Patients will be asked to fill in the PBAC score during the first menstrual period following diagnosis and during the three months of medical treatment or watch and wait approach. The "8-days PBAC score" is an objective method used to quantify menstrual blood loss; according to this method, each patient records the extent of uterine bleeding during the first 8 days of menstrual cycle, quantizing it in terms of daily change in diapers and number/size of the clots. Each option has a numeric value (1=no bleeding; 2=spotting; 3=1-8 diapers per day; 4=heavy bleeding) and, based on the result obtained, the monthly PBAC score varies from 0 (amenorrhea) to \> 500 (heavy bleeding). Menorrhagia occurs when PBAC score is \>100 during a menstrual cycle, corresponding to a blood loss greater than 80 ml.

University Magna Graecia

Principal investigator

Central Nervous System Depressants

Anesthetics

application of the laser diode by hysteroscopy to remove the endometrial polyp

application of the bipolar electrode Versapoint by hysteroscopy to remove the endometrial polyp

resection of endometrial polyps by hysteroscopy without anesthesia

polyps resection with Laser Diode

polyps resection with bipolar electrode

José Eduardo Arjona Berral, Gynecologist

Maria Dolores Lara, Gynecologist

Rafaela Dios Palomares, Engineer

Hysteroscopy today is considered the gold standard for the diagnosis and treatment of endometrial polyps. In recent years we have used the bipolar energy for resection of polyps by hysteroscopy, becoming a routine clinical practice and universally accepted.

Resection of endometrial polyps laser energy has recently begun to be used with satisfactory results, so studies are needed to analyze these results and compare it with the usual techniques .

This time in advance of medicine, it is appropriate to introduce minimally invasive procedures , allowing resection of endometrial polyps on an outpatient basis without anesthesia and acceptable to most patients.

These procedures assume a lower cost and are associated with a lower surgical risk due to their realization without anesthesia .

Hypothesis: Resection of polyps outpatient laser diode has a similar or superior to that of the bipolar electrode tolerability. The diode laser is a viable , quick , simple technique with a high percentage of resection and high degree of satisfaction of patients

Main objective: To assess the tolerability of diode laser in the treatment of endometrial polyps using a visual analogue pain scale.

Secondary objectives:

* Determine if complete resection of polyps is achieved with both methods.
* Compare the time spent on the removal of the polyp in each of the hysteroscopic methods.
* To evaluate the safety of the laser diode with respect to the bipolar electrode (vagal syndrome, uterine perforation, infection, bleeding).
* Assess the recurrence of polyps after 3 months of resection (via hysteroscopy).
* Compare the degree of patient satisfaction with the different methods.

Design: randomized single blind clinical trial corresponds to an experimental analytical study. The patients randomly into 2 groups will include: Group A bipolar electrode treatment Versapoint and Group B diode laser treatment. Randomization was performed using a random table with 2 groups, generated in Microsoft Office Excel. The sample size needed to detect a difference in visual analog pain scale of a point with respect to the laser diode bipolar electrode is calculated; assuming a standard deviation of 1.75, a sample size of 49 patients in each group (98 would be needed in total), to a level of significance of 5% (0.05 α) with a power of 0.80 (beta 0.20). Assuming a loss of individuals from 5 to 10%

Comparative Study of Endometrial Polypectomy Performed With Bipolar Electrode Versapoint and Laser Diode. A Randomised Controlled Trial.

Hospital Universitario Reina Sofia de Cordoba

Universidad Nacional de Córdoba

Isabel Bejerano Blázquez

IMIBIC

Endometrial Neoplasms

Hyperplasia

Endometrial Hyperplasia

All women who would be offered hysteroscopy guided biopsy as standard of care will be offered ultrasound guided biopsy first.

For women needed a hysteroscopy guided biopsy as part of routine standard of care, women will now receive an ultrasound guided biopsy first

Ultrasound guided biopsy

Diana Marcus, MB BS

Joseph Yazbek

Sadaf Ghaem-Maghami, FRCOG PhD

Jospeh Yazbek, FRCOG

Aim: Assess accuracy of histological diagnosis using ultrasound guided biopsy for women with suspected endometrial cancer (as an alternative to hysteroscopy guided biopsy).

All women presenting to clinic with suspected endometrial cancer will have an internal ultrasound. If the endometrial lining is thickened an endometrial biopsy will be performed. This can sometimes be done in an outpatient clinic, or sometimes a hysteroscopy and biopsy is needed (on a different day). Hysteroscopy guided biopsy has the advantage of enabling the clinician to perform directed biopsies under vision.

Ultrasound guided biopsy is a ubiquitous procedure when used elsewhere in the body however it is not routinely used in this context. It does have the advantage of being easily performed on the same day as the first consultation. In this pilot study we will assess the diagnostic ability and tolerability of ultrasound guided biopsy of women with suspected cancer, as an alternative to hysteroscopy guided biopsy.

Aims: Assess accuracy of histological diagnosis using ultrasound guided biopsy for women with suspected endometrial cancer (as an alternative to hysteroscopy guided biopsy).

Background:

Endometrial cancer is a tumour originating in the endometrium (womb lining); it is the most common gynaecological cancer in the UK. Although routine management for these women does vary, in general a screening test is performed, typically a pelvic (internal) ultrasound to assess the endometrium (womb lining). In cases where the endometrial thickness is above the threshold for investigation - an endometrial biopsy (sampling cells from the womb lining) is indicated. The biopsy can be taken blindly or under scan or hysteroscopic guidance. Hysteroscopy, the insertion of a small camera into the womb to visualise the womb lining allows direct visualization of the cavity. This usually occurs at a separate consultation in an outpatient setting or under general anaesthesia.

In theory an ultrasound-guided biopsy using a very fine Bettocchi forceps could be used instead of hysteroscopy- guided biopsies of the endometrium. The technique of ultrasound-guided biopsy is ubiquitous when used elsewhere in the body. It is frequently used to provide histological diagnosis of pelvic masses, (presumed ovarian origin), both abdominally (scanning of the tummy) and transvaginally (internally). Potentially ultrasound guided biopsies could be used as a cheaper, faster and less painful alternative to a hysteroscopy directed biopsies. This pilot study will be the first to assess the diagnostic ability of ultrasound guided biopsy in the assessment of women with suspected endometrial cancer.

The study:

All women will receive a pelvic (internal) ultrasound as per routine care. If the endometrium (womb lining) is thickened \>4mm on ultrasound they will require an endometrial biopsy. Usually this will be a pipelle. In cases where the pipelle biopsy cannot be performed in clinic due to poor tolerance, insufficient material or focal lesions a hysteroscopy guided biopsy will be required (local or GA).

In this case, the patients will be offered an ultrasound (USS) guided biopsy in the first instance, this will be performed at the same time in clinic. The biopsy will be taken under scan guidance using a very fine forceps such as Bettochi forceps. These forceps are used routinely during hysteroscopy so whilst the instruments are common the application is novel. The biopsy results of this will be sent for standard histology. If the results are inadequate patients will be sent for standard hysteroscopy and biopsy. Patients will also be asked to assess tolerability of the procedure using a visual analogue score.

Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?

Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy in the Detection of Endometrial Cancer?

Accuracy of histological diagnosis using ultrasound guided biopsy.

Visual analogue score will be given to patients post procedure to assess tolerability of the procedure

Imperial College London

Carcinoma

Precancerous Conditions

Hysteroscopy is a well established minimally invasive surgery method for diagnostic and intervention operations inside the uterine cavity. Using this method one can observe the endometrium and remove polyps.

Hysteroscopic polypectomy

Arie Lissak, MD

The prevalence of endometrial polyp is 24% in the general population but is much higher in postmenopausal women. The incidence of malignant or pre-malignant findings in endometrial polyps ranges from 2 to 10% in menopausal women.

Removal of endometrial polyps in postmenopausal symptomatic women is the standard of care, same goes for asymptomatic women with risk factors for endometrial malignancy, however treatment of asymptomatic postmenopausal women with endometrial polyp but no risk factors is disputable.

In light of ambiguity in literature regarding the rate of malignant and pre-malignant findings in polyps in asymptomatic post-menopausal women, the investigators are asking to conduct a prospective study in order to evaluate and compare the incidence of malignant and pre-malignant changes in symptomatic and asymptomatic postmenopausal women with endometrial polyp

Endometrial polyp is a common finding in postmenopausal women. The prevalence of endometrial polyps is 24% in the general population, but is much higher in postmenopausal in compare to premenopausal women. The incidence of malignant or pre-malignant findings in endometrial polyps ranges from 0.5 to 4.8% in the general population and from 2 to 10% in menopausal women. There is an increased risk for malignant or pre-malignant polyp in postmenopausal women and it correlates with age.

Removal of endometrial polyps in postmenopausal symptomatic (bleeding, pain, vaginal discharge) women is the standard of care, same goes for asymptomatic women with risk factors (e.g., hypertension, history of breast, ovary, endometrial or colon cancer, Tamoxifen or estrogen treatment, over-weight, no ovulation, previous endometrial hyperplasia) due to a relatively high risk for malignancy. However treatment of asymptomatic postmenopausal women endometrial polyp but no risk factors is disputable.

Article published in the recent years introduced a similar rate of involvement of malignant and pre-malignant changes in polyps removed from post-menopausal women, symptomatic and asymptomatic (3.2% versus 3.9%, respectively).

In light of ambiguity in literature regarding the rate of malignant and pre-malignant findings in polyps in asymptomatic post-menopausal women, and in light of the fact that all major studies in this field were made retrospectively, we are asking to conduct a prospective study in order to evaluate and compare the incidence of malignant and pre-malignant changes in symptomatic and asymptomatic postmenopausal women with endometrial polyp

Incidence of Malignant and Premalignant Endometrial Polyp in Asymptomatic and Symptomatic Postmenopausal Women

Incidence of Malignant and Pre-malignant Findings in Endometrial Polyp in Asymptomatic and Symptomatic Postmenopausal Women

Head of gynecologic minimally invasive surgery unit, Carmel Medical Center.

Dydrogesterone

Participants enrolled are given dydrogesterone tablet of 10mg twice a day, from day 15 to day 24 of the menstrual cycle over a period of 3 months.

The investigators give participants oral dydrogesterone(as described in arm description).After 3 cycles of treatment, the investigators evaluate the treatment effects.

This study is intended to observe the therapeutic effect of dydrogesterone on endometrial polyps and provide a reference for clinical treatment.

Endometrial polyps are a common female endometrial lesion.The long-term unrestrained exposure of estrogen to local tissue is one of the causes of polyp formation.Studies suggested that the progesterone can accelerate the regression rate of endometrial polyps due to its antiestrogenic effects.Based on this, investigators intended to observe the therapeutic effect of dydrogesterone on endometrial polyps and provide a reference for clinical treatment.

Dydrogesterone in the Treatment of Endometrial Polyps

Prospective One-arm Cohort Study of Dydrogesterone in the Treatment of Endometrial Polyps

No evidence of polyps or the maximum dimensions of polyps are reduced by 1/3 or more under pelvic ultrasound

Evidence of polyps or the maximum dimensions of polyps are larger during the follow-up of the regression group after treatment

Peking Union Medical College Hospital

Associate Professor

The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.

Beclin 1 gene

Burak SEZGİN, MD

The aim of this research is to evaluate autophagy markers in patients with endometrial polyps

Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.

Autophagy Markers in Endometrial Polyps

Investigation of Autophagy Markers in Endometrial Polyps

When we conducted the study, we will plan to make individual participant data (IPD) available to other researchers.

Muğla Sıtkı Koçman University

Principal investigator M.D. Burak Sezgin

Skin and Connective Tissue Diseases

Leiomyoma

Syndrome

Myofibroma

Tissue Adhesions

Myoma

Gynatresia

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

Asherman's Syndrome

injection of intercoat into the euterine cavity at the end of hysteroscopy

Applying INTERCOAT in the intrauterine cavity at the end of the hysteroscopic surgery

INTERCOAT administration

Moran PAZ, M.D.

Yuval Kaufman, M.D.

Moran Paz, MD

Yuval Kaufman, MD

The study purpose is to examine the influence of INTERCOAT in prevention of intra-uterine adhesions formation after any hysteroscopic surgery.

Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery

Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery - a Prospective Double Blind Randomized Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Observational Study of the Association Between Food Intake and Endometrial Polyps	NCT06295510	Diet Habit Endometrial Pol... Women	No intervention...	-	Chengdu University of Traditional Chinese Medicine
Endometrial Polyps Regression With Progesterone Therapy	NCT03309709	Endometrial Pol...	subcutaneous pr...	18 Years - 50 Years	University Magna Graecia
Comparative Study of Endometrial Polypectomy Performed With Bipolar Electrode Versapoint and Laser Diode. A Randomised Controlled Trial.	NCT02126397	Endometrial Pol...	polyps resectio... polyps resectio...	18 Years -	Maimónides Biomedical Research Institute of Córdoba
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?	NCT03207126	Endometrial Can... Endometrial Neo... Endometrial Hyp... Endometrial Pol...	Ultrasound guid...	18 Years -	Imperial College London
Incidence of Malignant and Premalignant Endometrial Polyp in Asymptomatic and Symptomatic Postmenopausal Women	NCT01203176	Endometrial Pol... Malignant and P...	Hysteroscopic p...	18 Years - 80 Years	Carmel Medical Center
Dydrogesterone in the Treatment of Endometrial Polyps	NCT03790215	Endometrial Pol...	Dydrogesterone	20 Years - 50 Years	Peking Union Medical College Hospital
Autophagy Markers in Endometrial Polyps	NCT04706000	Endometrial Pol... Autophagy	Beclin 1 gene	35 Years -	Muğla Sıtkı Koçman University
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?	NCT03207126	Endometrial Can... Endometrial Neo... Endometrial Hyp... Endometrial Pol...	Ultrasound guid...	18 Years -	Imperial College London
Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery	NCT01637974	Asherman Syndro... Endometrial Pol... Uterine Myoma	INTERCOAT admin...	18 Years - 50 Years	Carmel Medical Center
Observational Study of the Association Between Food Intake and Endometrial Polyps	NCT06295510	Diet Habit Endometrial Pol... Women	No intervention...	-	Chengdu University of Traditional Chinese Medicine

Spots Global Cancer Trial Database for endometrial polyp