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Esophageal Cancer

Oculocerebral Syndrome With Hypopigmentation

The gene polymorphism of ERCC1 rs11615 and the pathways of ERRC1 will be analyzed in endoscopic tumor biopsies as well as in normal tissues prior to therapy. The results will be compared with histopathologic response after neoadjuvant therapy.

ERCC1 pathways analysis

Arnulf H. Hölscher, MD

RATIONALE: The prognosis of patients with advanced esophageal cancer may be improved by preoperative chemoradiation. But only those patients have a benefit from this additional therapy, whose tumor shows a response after chemoradiation. Molecular markers may help to identify before starting the therapy those patients who response.

PURPOSE: This is the first prospective, clinical trial to study the impact of ERCC1 to predict histopathological response to neoadjuvant radiochemotherapy (RTx/CTx) in patients with cancer of the esophagus.

Cologne Esophageal Response Prediction Study (CERP-Study)

Prospective Study to Analyze the Predictive Role of Factors Implicated in the Signaling Pathway of ERCC1 in Response to Treatment With Neoadjuvant Radiochemotherapy in Patients With Esophageal Cancer

Patients with cT3 esophageal cancer received RTx/CTx according a standardized protocol. 6 weeks after this neoadjuvant therapy a tranthoracic esophagectomy with two-field lymphadenectomy will be performed.

The histopathologic response is measured using the surgical specimen.

All patients get a standardized follow-up every three month evaluating clinical signs of response. If necessary additional diagnostic procedures will be performed.

Elfriede Bollschweiler

Professor of Surgical Research

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Cologne Esophageal Response Prediction Study (CERP-Study)	NCT00953511	Esophageal Canc...	ERCC1 pathways ...	18 Years -	University of Cologne
Cologne Esophageal Response Prediction Study (CERP-Study)	NCT00953511	Esophageal Canc...	ERCC1 pathways ...	18 Years -	University of Cologne

Spots Global Cancer Trial Database for ercc1 pathways analysis