Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Heart and Blood Diseases

Symptoms and General Pathology

Neoplasms

Digestive System Diseases

Respiratory Tract (Lung and Bronchial) Diseases

Gland and Hormone Related Diseases

Nervous System Diseases

Mouth and Tooth Diseases

Ear, Nose, and Throat Diseases

Rare Diseases

Kidney Diseases

Hypertension

Essential Hypertension

Syndrome

Stomach Neoplasms

Lung Neoplasms

Pancreatic Neoplasms

Epilepsy

Acute Coronary Syndrome

Chronic Disease

Liver Neoplasms

Dysbiosis

Nasopharyngeal Carcinoma

Hypothyroidism

Urologic Diseases

Hyperaldosteronism

Endocrine System Diseases

Nasopharyngeal Neoplasms

Carcinoma

Renal Insufficiency, Chronic

Renal Insufficiency

Vascular Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Disease Attributes

Coronary Artery Disease

Myocardial Ischemia

Ischemia

Heart Diseases

Thyroid Diseases

Adrenocortical Hyperfunction

Adrenal Gland Diseases

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Head and Neck Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Otorhinolaryngologic Diseases

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Chronic Graft Versus Host Disease

Stomach Cancer

Pancreatic Cancer

Acute Graft Versus Host Disease

Hyperadrenalism

no intervention

Jiahui Zhang

Hui Xu

Wenming Wang

Xiaoli Zhang

Yingping Cao

Falin Chen

Yan Chen

Liqiong Yao

Gechong Yong

Tian Cai

Minmin Li

Zhaofan Luo

Kang Chen

Li Xie

Yulin Yuan

Minzhong Tang

Wei Wang

Hai Huang

Xiang Wu

Dejun Yun

Yingyu Jin

Haiyan Gao

Jinyu Yang

Wenxiu Liu

Zhanjun Zhang

Tao Jiang

Weibing Yin

Xiaoliang Zhou

Zhengjiang Cheng

Xuesheng Li

Zuiming Jiang

Guoli Liu

Hongyu Huang

Honghou Dai

Tianyu Zhong

Xiaozhong Wang

Jufen Ma

Kunping Guan

Yuanyuan Pan

Hongli Liu

Zhuo Li

Yuan Liu

Yuanjiu Xu

Yin Xiang

Kai Chen

Heng Zhang

Li Ren

Aimin Xu

Yong Duan

Fuxing Zhang

Yufeng Liao

Yan He

The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them. This study aims to systematically characterize the gut microbiota of various critical chronic diseases, compare the similarities and differences of the microbiome signatures linked to different regions and diseases, and further investigate their impacts on microbiota-based diagnostic models.

Many studies demonstrate that microbial dysbiosis has been linked to many human pathologies. However, the current understanding of the identification of the disease-associated microbiome signatures remains limited, largely owing to the heterogeneity of microbial community structures which are shaped by the host. Undoubtedly, profiles of microbial biomarkers require validation in large, independent, population-based cohorts from different districts. Based on these, the investigator plan to organize a multicentric cross-sectional cohort, not only to systematically characterize the gut microbiota of various critical chronic diseases, such as liver cancer, gastric cancer, pancreatic cancer, lung cancer, nasopharyngeal cancer, hypertension, acute coronary syndrome, primary aldosteronism, epilepsy, chronic kidney disease, and subclinical hypothyroidism but also to compare the similarities and differences of the microbiome signatures linked to different regions and different diseases and to further investigate their impacts on microbiota-based diagnostic models. In this study, for each kind of disease, the investigators expect to recruit 500 patients with a confirmed diagnosis and 500 sex- and age-matched controls, to record their information related to demography, body measurement, lifestyle, diet, medication, diseases, and biochemistry, and to collect their feces, saliva, urine and blood samples.

Feces, saliva, urine, serum, plasma and buffy coat

A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China

The microbial composition of the stool and saliva samples was determined by 16S rRNA (ribosomal ribonucleic acid) gene sequencing analysis and metagenomics. Comparison of microbial abundance and diversity of healthy volunteers and patients with various diseases.

Comparison of serum markers of healthy volunteers and patients with various diseases.

Comparison of metabolites of healthy volunteers and patients with various diseases.

Comparison of peptides of healthy volunteers and patients with various diseases using mass spectrometry.

National Natural Science Foundation of China

Zhujiang Hospital

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China	NCT05638269	Essential Hyper... Liver Cancer Nasopharyngeal ... Pancreatic Canc... Lung Cancer Chronic Kidney ... Acute Coronary ... Epilepsy Gastric Cancer Primary Aldoste... Subclinical hyp...	no intervention	18 Years - 75 Years	Zhujiang Hospital
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China	NCT05638269	Essential Hyper... Liver Cancer Nasopharyngeal ... Pancreatic Canc... Lung Cancer Chronic Kidney ... Acute Coronary ... Epilepsy Gastric Cancer Primary Aldoste... Subclinical hyp...	no intervention	18 Years - 75 Years	Zhujiang Hospital

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