Spots Global Cancer Trial Database for A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
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Trial Identification
Brief Title: A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
Official Title: A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
Study ID: NCT05638269
Interventions
Study Description
Brief Summary: The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them. This study aims to systematically characterize the gut microbiota of various critical chronic diseases, compare the similarities and differences of the microbiome signatures linked to different regions and diseases, and further investigate their impacts on microbiota-based diagnostic models.
Detailed Description: Many studies demonstrate that microbial dysbiosis has been linked to many human pathologies. However, the current understanding of the identification of the disease-associated microbiome signatures remains limited, largely owing to the heterogeneity of microbial community structures which are shaped by the host. Undoubtedly, profiles of microbial biomarkers require validation in large, independent, population-based cohorts from different districts. Based on these, the investigator plan to organize a multicentric cross-sectional cohort, not only to systematically characterize the gut microbiota of various critical chronic diseases, such as liver cancer, gastric cancer, pancreatic cancer, lung cancer, nasopharyngeal cancer, hypertension, acute coronary syndrome, primary aldosteronism, epilepsy, chronic kidney disease, and subclinical hypothyroidism but also to compare the similarities and differences of the microbiome signatures linked to different regions and different diseases and to further investigate their impacts on microbiota-based diagnostic models. In this study, for each kind of disease, the investigators expect to recruit 500 patients with a confirmed diagnosis and 500 sex- and age-matched controls, to record their information related to demography, body measurement, lifestyle, diet, medication, diseases, and biochemistry, and to collect their feces, saliva, urine and blood samples.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Emergency General Hospital, Chaoyang, Beijing, China
The People's Hospital Of Nanchuan Chongqing, Nanchuan, Chongqing, China
YongChuan hospital of Chongqing Medical Univeristy, Yongchuan, Chongqing, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
Fujian Provincial Hospital, Fuzhou, Fujian, China
Fujian Cancer Hospital, Fuzhou, Fujian, China
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
Lanzhou University Second Hospital, Lanzhou, Gansu, China
The Sixth Affiliated Hospital of South China University of Technology (Foshan Nanhai District People's Hospital ), Foshan, Guangdong, China
The First Affiliated Hospital of Jinan University（Guangzhou Overseas Chinese Hospital ）, Guangzhou, Guangdong, China
The seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
Zhongshan City People's Hospital, Zhongshan, Guangdong, China
The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
Wuzhou Red Cross Hospital, Tongliao, Guangxi, China
The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China
The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Hainan Traditional Chinese Medicine Hospital, Haikou, Hainan, China
Daqing People's Hospital（The Fifth Affiliated Hospital of Harbin Medical University）, Daqing, Heilongjiang, China
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Jixi Ji Mine Hospital, Jixi, Heilongjiang, China
Qiqihar Hospital of Traditional Chinese Medicine, Qiqihar, Heilongjiang, China
Luoyang Maternal and Child Health Hospital, Luoyang, Henan, China
Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine,Medical College of Henan University of Science and Technology, Luoyang, Henan, China
Shangqiu First People's Hospital, Shangqiu, Henan, China
Wuhan Mental Health Center, Wuhan, Hubei, China
Xiangyang Central Hospital, Xiangyang, Hubei, China
Nanzhang People's Hospital, Xianyang, Hubei, China
Zhuzhou Central Hospital, Zhuzhou, Hunan, China
Affiliated Hospital of Inner Mongolia Minzu University, Wuzhou, Inner Mongolia Autonomous Region, China
Wuxi No.2 People's Hospital, Wuxi, Jiangsu, China
Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi, China
First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangx, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangx, China
Chang Zhi Yi Xue Yuan Fu Shu He Ji Yi Yuan, Changzhi, Shanxi, China
The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
The Hospital of Shanxi University of Chinese Medicine, Taiyuan, Shanxi, China
Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, Shanxi, China
The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shanxi, China
The General Hospital of Western Theater Command PLA, Chengdu, Sichuan, China
Guang'an People's Hospital, Guang'an, Sichuan, China
The People's Hospital of Leshan, Leshan, Sichuan, China
Tianjin Beichen Hospital, Beichen, Tianjin, China
Tianjin Binhai New Area Dagang Hospital, Binhai, Tianjin, China
Tianjing Medical University Cancer Institute & Hospital, Hexi, Tianjin, China
The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang Uygur Autonomous Region, China
First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
Qunjing Hospital of Traditional Chinese Medicine, Qujing, Yunnan, China
Hwa Mei Hospital,University of Chinese Academy of Sciences, Ningbo, Zhejiang, China
Contact Details
Name: Yan He
Affiliation: Zhujiang Hospital
Role: STUDY_CHAIR
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