Neoplasms

All Conditions

Eye Diseases

Symptoms and General Pathology

Carcinoma

Carcinoma, Squamous Cell

Carcinoma, Basal Cell

Eyelid Neoplasms

Adenocarcinoma, Sebaceous

Facies

Facial Neoplasms

Head and Neck Neoplasms

Eye Neoplasms

Eyelid Diseases

patients in this group received both Mohs surgery and cryotherapy.

patients in this group received only Mohs surgery.

Mohs surgery

cryotherapy

Huasheng Yang, M.D, PHD

Huasheng Yang, Doctor

This study aim to investigate whether the prognosis of eyelid malignant tumor is better treated with Mohs surgery combind with cryotherapy than Mohs surgery only.

This study is a randomized perspective study. American Joint Committee on Cancer was applied to define the cancer stage of patients recruited. Patients with Tis to T3cN0M0 will be randomized to receive Mohs surgery or Mohs suregery conbind cryotherapy. Patients will be followed for 3 years.

Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.

Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors: a Prospective Randomized Controlled Study.

measure the tumor recurrence rate for the two groups at three years

measure the tumor progression rate for the two groups at three years

measure the mortality rate for the two groups(Cancer-related death and non-Cancer-related death) at three years

numbers of participants with side effects

Sun Yat-sen University

Diseases and Abnormalities at or Before Birth

Infections

Congenital Abnormalities

Papilloma

Abscess

Neoplasms, Squamous Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Central Nervous System Depressants

All Drugs and Chemicals

Anti-Arrhythmia Agents

Channel Blockers

Vasoconstrictor Agents

Respiratory System Agents

Anesthetics

Lidocaine

Epinephrine

Anesthetics, Local

Racepinephrine

Epinephryl borate

Sodium Channel Blockers

Diuretics, Potassium Sparing

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

Adrenergic beta-Agonists

Bronchodilator Agents

Anti-Asthmatic Agents

Mydriatics

Sympathomimetics

Patients receiving bacteriostatic saline as local anesthesia for in-office minor eyelid procedures at University of California, San Francisco Medical Center, Oculoplastics department

Patients receiving lidocaine with epinephrine as local anesthesia for in-office minor eyelid procedures at University of California, San Francisco Medical Center, Oculoplastics department

Following research and procedural consent, local anesthetic injection will be carried out using a standard 1 cc of local anesthetic corresponding to the study arm (0.9% bacteriostatic saline or 1% lidocaine with 1:100,000 epinephrine). Prior to anesthetic administration, the procedure site will be cleaned using standard measures. A 30 gauge needle on a 3 centimeter cubed volume syringe will be utilized. Five minutes will be given for local anesthetic to take effect.

0.9% Bacteriostatic Local Anesthetic Injection

Following research and procedural consent, local anesthetic injection will be carried out using a standard 1 cc of local anesthetic consisting of a commercially available mixture of 1% lidocaine with 1:100,000 epinephrine. Prior to anesthetic administration, the procedure site will be cleaned using standard measures. A 30 gauge needle on a 3 centimeter cubed volume syringe will be utilized. Five minutes will be given for local anesthetic to take effect.

1% Lidocaine with 1:100,000 epinephrine Local Anesthetic Injection

Following anesthesia administration, patient will proceed with recommended eyelid lesion removal. The procedure site will be cleaned according to standard protocol, and standard technique for lesion removal will be performed, which will vary according to type of lesion but may involve use of Westcott scissors, forceps, #15 or #11 blades or other oculoplastics administration. The exact procedural details will be at the discretion of the surgeon.

Eyelid Lesion Removal

Robert Kersten, MD

The investigators aim to assess whether bacteriostatic saline provides the same level of anesthesia as traditional local anesthesia while reducing pain associated with medication infusion in minor eyelid procedures

Benzoyl alcohol is an aromatic alcohol that has been used in healthcare primarily as an antibacterial preservative agent in bacteriostatic saline. It has also been shown to have anesthetic properties, and has been demonstrated to cause less pain with infusion compared to lidocaine, while maintaining adequate pain relief. The use of bacteriostatic saline alone as an anesthetic for incisional procedures in the periocular area has not yet been studied. The purpose of this study was to determine whether bacteriostatic saline provides an adequate level of anesthesia for minor in-office eyelid procedures while allowing for reducing pain associated with medication infusion compared with traditional local anesthetic agents. To assess this, the investigators will recruit 150 patients aged 18 or older undergoing minor eyelid procedures including eyelid biopsies, chalazion removal from outpatient oculoplastics clinics at UCSF. Patients will be randomized in a 1:1 fashion to undergo local anesthetic with either 1% lidocaine with 1:100,000 epinephrine or 0.9% bacteriostatic saline. Primary outcome measure will be pain level on a scale of 1-10 with regards to injection and procedure itself. These will be compared between the two groups. The investigators hypothesize that bacteriostatic saline is superior to lidocaine with epinephrine in terms of pain with injection, but will result in a similar pain level during the procedure.

Patient and provider performing procedure will be masked to local anesthesia type

Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures

Pain on a scale of 0-10 during injection process (0 being no pain, 10 being worst pain ever experienced). These will be patient-reported verbally and recorded immediately after injection.

Pain on a scale of 0-10 during procedure (0 being no pain, 10 being worst pain ever experienced). These will be patient-reported verbally and recorded immediately after procedure.

Need for additional anesthesia to complete procedure

Physician-assessed level of bleeding after procedure (mild, moderate, severe). These will be physician-reported verbally and recorded immediately after procedure.

University of California, San Francisco

Skin and Connective Tissue Diseases

Keratosis, Actinic

Keratosis

Nevus, Pigmented

Nevus

Skin Diseases

Melanoma

Nevi and Melanomas

The study investigates the use of the Ultrapulse Carbon Dioxide Laser for the excision of eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

Ultra-pulsed Carbon Dioxide Laser

Dingqiao Wang, PhD

Xianchai Lin, Doctor

Xianchai Lin, PhD

This study aims to assess the long-term efficacy and safety of ultrapulse carbon dioxide (CO₂) laser excision in the treatment of eyelid tumors, including xanthelasma, pigmented nevi, keratoses, and so on.

-Background: The assessment of the efficacy and safety of Ultrapulse CO₂ laser in treating eyelid lesions is crucial for clinical applications. This study aims to evaluate the effectiveness of super-pulsed CO₂ laser in treating different types of eyelid lesions, particularly marginal and large lesions, to provide comprehensive clinical guidance and decision support.

-Main Objectives: A retrospective analysis of the efficacy and safety of Ultrapulse CO₂ laser treatment for various types of eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

-Study Design: This study will include 1000 patients diagnosed with eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on. All patients undergoing Ultrapulse CO₂ laser treatment. The evaluation will focus on the efficacy and safety of Ultrapulse CO₂ laser treatment for different types of eyelid lesions.

-Study Population and Anticipated Enrollment: Patients with eyelid lesions (n=1000)

-Inclusion Criteria: Clinically diagnosed with eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

No history of photosensitivity, bleeding, or coagulation disorders Willing to attend follow-up appointments as scheduled

-Exclusion Criteria: Presence of infection in the target area Allergy to lidocaine Keloid-prone or poor skin repair ability Pregnant or lactating Recent history of severe infectious diseases, active skin diseases, or major diseases affecting the cardiovascular, liver, kidney, endocrine, and hematopoietic systems History of malignant tumors or immune system disorders

Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors

The lesion clearance rate was classified as the proportion of the lesion cleared (\<50%; 50-75%; 76-99%; or \>99%).

Recurrence was defined as the regrowth of a new xanthelasma lesion within the previously excised area.

Lesion recurred, minor trichiasis, partial sparse to absent eyelashes, hypertrophic scar, hyperpigmentation

Investigator's Global Assessment (IGA) score for measuring improvement in clinical outcomes: 1=worsened; 2=no change; 3=minor improvement; 4=moderate improvement; 5=marked improvement; 6=near-total improvement; and 7=total improvement.

Patient satisfaction was evaluated subjectively by the physician on a f ve-point scale, as follows: 0=no change; 1=minor improvement; 2=moderate improvement; 3=marked improvement; 4=near-total or total improvement.

Number of treatment sessions for complete clearance

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.	NCT05072327	Eyelid Tumor	Mohs surgery cryotherapy	-	Sun Yat-sen University
Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures	NCT05294640	Eyelid Tumor Eyelid Bump Eyelid Deformit... Eyelid Abscess Eyelid Boil Eyelid Papillom... Anesthesia, Loc... Ophthalmology	0.9% Bacteriost... 1% Lidocaine wi... Eyelid Lesion R...	18 Years - 110 Years	University of California, San Francisco
Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures	NCT05294640	Eyelid Tumor Eyelid Bump Eyelid Deformit... Eyelid Abscess Eyelid Boil Eyelid Papillom... Anesthesia, Loc... Ophthalmology	0.9% Bacteriost... 1% Lidocaine wi... Eyelid Lesion R...	18 Years - 110 Years	University of California, San Francisco
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University

Spots Global Cancer Trial Database for eyelid tumor

Every month we try and update this database with for eyelid tumor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.