Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Rare Diseases

Melanoma

Skin Neoplasms

Nevus, Pigmented

Nevus

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Nevi and Melanomas

Skin Diseases

Neuroendocrine Tumor

Neuroepithelioma

Malignant Melanoma is a deadly skin cancer that can be cured if diagnosed early. To date atypical pigmented skin lesions are diagnosed by appearance alone and many moles and lesions are excised unnecessarily and on the other hand malignant lesions are missed and diagnosed too late. In this study a protein conjugated to a florescent dye is spread on a suspicious pigmented lesion, the hypothesis is that this protein binds to malignant cells only and thus with a special camera that picks up the dye we can find pigmented lesions with early malignant transformation.

Early Diagnosis of Malignant Transformation of Pigmentary Skin Lesions

Early Diagnosis of Malignant Melanoma Transformation in Pigmentary Skin Lesions

Hadassah Medical Organization

Eye Diseases

Symptoms and General Pathology

Keratosis, Actinic

Keratosis

Eyelid Neoplasms

Facies

Facial Neoplasms

Head and Neck Neoplasms

Eye Neoplasms

Eyelid Diseases

The study investigates the use of the Ultrapulse Carbon Dioxide Laser for the excision of eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

Ultra-pulsed Carbon Dioxide Laser

Dingqiao Wang, PhD

Xianchai Lin, Doctor

Xianchai Lin, PhD

This study aims to assess the long-term efficacy and safety of ultrapulse carbon dioxide (CO₂) laser excision in the treatment of eyelid tumors, including xanthelasma, pigmented nevi, keratoses, and so on.

-Background: The assessment of the efficacy and safety of Ultrapulse CO₂ laser in treating eyelid lesions is crucial for clinical applications. This study aims to evaluate the effectiveness of super-pulsed CO₂ laser in treating different types of eyelid lesions, particularly marginal and large lesions, to provide comprehensive clinical guidance and decision support.

-Main Objectives: A retrospective analysis of the efficacy and safety of Ultrapulse CO₂ laser treatment for various types of eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

-Study Design: This study will include 1000 patients diagnosed with eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on. All patients undergoing Ultrapulse CO₂ laser treatment. The evaluation will focus on the efficacy and safety of Ultrapulse CO₂ laser treatment for different types of eyelid lesions.

-Study Population and Anticipated Enrollment: Patients with eyelid lesions (n=1000)

-Inclusion Criteria: Clinically diagnosed with eyelid lesions, including xanthelasma, pigmented nevi, keratoses, and so on.

No history of photosensitivity, bleeding, or coagulation disorders Willing to attend follow-up appointments as scheduled

-Exclusion Criteria: Presence of infection in the target area Allergy to lidocaine Keloid-prone or poor skin repair ability Pregnant or lactating Recent history of severe infectious diseases, active skin diseases, or major diseases affecting the cardiovascular, liver, kidney, endocrine, and hematopoietic systems History of malignant tumors or immune system disorders

Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors

The lesion clearance rate was classified as the proportion of the lesion cleared (\<50%; 50-75%; 76-99%; or \>99%).

Recurrence was defined as the regrowth of a new xanthelasma lesion within the previously excised area.

Lesion recurred, minor trichiasis, partial sparse to absent eyelashes, hypertrophic scar, hyperpigmentation

Investigator's Global Assessment (IGA) score for measuring improvement in clinical outcomes: 1=worsened; 2=no change; 3=minor improvement; 4=moderate improvement; 5=marked improvement; 6=near-total improvement; and 7=total improvement.

Patient satisfaction was evaluated subjectively by the physician on a f ve-point scale, as follows: 0=no change; 1=minor improvement; 2=moderate improvement; 3=marked improvement; 4=near-total or total improvement.

Number of treatment sessions for complete clearance

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Early Diagnosis of Malignant Transformation of Pigmentary Skin Lesions	NCT01167998	Malignant Melan... Pigmented Nevi Skin Neoplasm		18 Years -	Hadassah Medical Organization
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University
Efficacy and Safety of Ultrapulse Carbon Dioxide Laser Treatment in Eyelid Tumors	NCT06206681	Eyelid Tumor Xanthelasma Pal... Pigmented Nevi Keratosis	Ultra-pulsed Ca...	18 Years - 80 Years	Sun Yat-sen University

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