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FUSA therapy and standard of care PD-1 blockade. FUSA therapy will be administered on day 8.

FUSA therapy, standard of care PD-1 blockade, and intratumoral poly-ICLC will be administered on day 8.

FUSA therapy will be administered on day 1.

FUSA therapy and intratumoral poly-ICLC will be administered on day 1.

The Echopulse device delivers focused ultrasound ablation (FUSA) therapy. FUSA is a technology that delivers continuous high-intensity focused ultrasound to ablate tissue.

Echopulse

PD-1 therapy FDA approved for use on a 3-week schedule will be used per standard of care.

Standard of Care PD-1 Therapy

Lynn Dengel, MD, MSc

This study evaluates whether it is safe to Focused Ultrasound Ablation (FUSA) treatments with and without PD-1 blockade and with and without intratumoral poly-ICLC. A device called the Echopulse will be used for the FUSA therapy. Patients will be assigned to 1 of 2 cohorts depending on their disease and treatment status. In Cohort 1, patients will receive FUSA therapy while receiving PD-1 blockade therapy as part of standard clinical care treatment. In Cohort 2, patients who discontinue or are ineligible for PD-1 blockade therapy will undergo FUSA without concurrent systemic therapy, with the goal of utilizing the FUSA to boost the innate immune response. The optional secondary regimen will combine FUSA (+/- PD-1 blockade) with intratumoral poly-ICLC.

Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors

Pilot Evaluation of Focused Ultrasound Ablation and Focused Ultrasound Ablation Plus PD-1 Antibody Blockade in Advanced Solid Tumors

De-identified individual participant data that underlie the results of this study may be shared.

Incidence and severity of adverse events and incidence of dose-limiting toxicities (DLTs).

Proportion of participants achieving at least a 2-fold increase in CD8+ T cell infiltration per mm2.

Proportion of participants achieving at least a 2-fold increase in CD8+ T cell infiltration per mm2

Theraclion

Craig L Slingluff, Jr

Professor of Surgery; Director, Human Immune Therapy Center

Spots Global Cancer Trial Database for fusa

Every month we try and update this database with for fusa cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for fusa

Every month we try and update this database with for fusa cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for fusa cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.