Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Nutritional and Metabolic Diseases

Lung Neoplasms

Malnutrition

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Nutrition Disorders

Microbial composition using probiotics,3 capsules/times,3 times/day for 3 to 4 weeks

Microbiota modulation using probiotics,3 capsules/times,3 times/day for 3 to 4 weeks

Probiotics

placebo

Yanqing Li, MD.PhD.

Probiotics modulate the gut microflora and immune status in lung cancer who need chemotherapy.

Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications. Probiotics may restore the intestinal immunity, mucosal barrier and nutrient absorption.

Intestinal Microflora in Lung Cancer After Chemotherapy

Primary coordination of fecal samples' 16s(%) rDNA will be compared between two groups using Braycurtis distance based Primary coordination analysis(PCoA)

Shandong University

Vice president of Qilu Hospital

Digestive System Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Microbial composition using Probiotic，3 capsules / times, 2 times / day for 4 weeks

Microbiota modulation using placebo，3 capsules / times, 2 times / day for 4 weeks

Probiotic

placebo（for probiotic）

Ming Li, MD

Yang Tian, MD

Yanqing Li, MD.PhD

Probiotics modulate the gut microflora and immune status in CRC,which can reduce the side effects of chemotherapy such as diarrhea,infection,neutropenia etc.

Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications; Probiotics may restore the intestinal immunity, mucosal barrier, and nutrient absorption.The adverse effects of chemotherapy and the malnutrition status may be relieved via probiotic administration.

Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy

Effects of Gut Microflora on the Immune and Nutritional Status of CRC Patients After Chemotherapy

Primary coordination of fecal samples' 16s rDNA (ribosomal DNA) will be compared between two Groups using Braycurtis distance based Primary coordination analysis (PCoA).

The total concentration of Short-chain fatty acids in the in feces of patients after chemotherapy.

Adverse effects includes vomiting, nausea, diarrhea and abdominal pain.

Immune status indexes include percentage of Neutrophils, total lymphocytes, lymphocyte subgroups, plasma immunoglobulin level, CRP (C reactive protein).

Nutritional status indexes include BMI, percentage of body weight changes, plasma albumin and prealbumin.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intestinal Microflora in Lung Cancer After Chemotherapy	NCT02771470	Lung Cancer Effects of Chem... Tumor Immunity Malnutrition	Probiotics placebo	18 Years - 80 Years	Shandong University
Intestinal Microflora in Lung Cancer After Chemotherapy	NCT02771470	Lung Cancer Effects of Chem... Tumor Immunity Malnutrition	Probiotics placebo	18 Years - 80 Years	Shandong University
Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy	NCT02169388	Gastrointestina... Colorectal Canc... Effects of Chem... Tumor Immunity Malnutrition	Probiotic placebo（for pro...	18 Years - 80 Years	Shandong University

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