Neoplasms

All Conditions

Digestive System Diseases

Carcinoma

Carcinoma, Hepatocellular

All Drugs and Chemicals

Imidacloprid

Immunosuppressive Agents

take advantage of RFA to destroy hepatocellular carcinoma by high temperature

radiofrequency ablation

Zhe Tang, Dr.

The study aims to find whether patients with advanced HCC can get more benefits from RFA +PD-1 immunosuppressant (carrizumab) compared with carrizumab alone, considering with the result of PFS.

The study aims to find whether patients with advanced HCC can get more benefits from RFA +PD-1 immunosuppressant (carrizumab) compared with carrizumab alone, considering with the result of PFS. 120 patients were enrolled into two groups respectively, the experimental group and reference group.

RFA Plus Carrizumab vs Carrizumab Alone for HCC

Radiofrequency Ablation Plus Carrizumab vs Carrizumab Alone for Moderate or Advanced Hepatocellular Carcinoma: A Real World Study

Time from patients received treatment fist time to disease progress or death

The ratio of patients with regressive disease ,including complete response and partial response

The ratio of patients with regressive or stable disease, including complete response, partial response and stable disease.

Time from the random assignment to death (the last follow-up time for patients lost to follow-up, the end of study for patients still alive

Time from the first time of complete regression or partial regression to progressive disease or death

Second Affiliated Hospital, School of Medicine, Zhejiang University

Respiratory Tract (Lung and Bronchial) Diseases

Nutritional and Metabolic Diseases

Lung Neoplasms

Malnutrition

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Nutrition Disorders

Microbial composition using probiotics,3 capsules/times,3 times/day for 3 to 4 weeks

Microbiota modulation using probiotics,3 capsules/times,3 times/day for 3 to 4 weeks

Probiotics

placebo

Yanqing Li, MD.PhD.

Probiotics modulate the gut microflora and immune status in lung cancer who need chemotherapy.

Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications. Probiotics may restore the intestinal immunity, mucosal barrier and nutrient absorption.

Intestinal Microflora in Lung Cancer After Chemotherapy

Primary coordination of fecal samples' 16s(%) rDNA will be compared between two groups using Braycurtis distance based Primary coordination analysis(PCoA)

Shandong University

Vice president of Qilu Hospital

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Uterine Cervical Neoplasms

Insulin Resistance

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Hyperinsulinism

Metabolic Diseases

Glucose Metabolism Disorders

Central Nervous System Depressants

Hypoglycemic Agents

Anesthetics

Insulin

Insulin, Globin Zinc

receive 300mL of an oral carbohydrate liquid supplement 2 hour before surgery

fast on standard hospital protocol (8 hour fasting for solid and 4 hour fasting for clear liquid

patients undergoing neoadjuvant chemotherapy and radical hysterectomy with bilateral pelvic lymph node dissection were randomized to receive 300mL of an oral carbohydrate liquid supplement 2 hour before surgery

oral carbohydrate liquid

To evaluate the effects of preoperative oral carbohydrate on postoperative insulin resistance and tumor immunity in cervical cancer patients with neoadjuvant chemotherapy.

Fifty-one patients undergoing neoadjuvant chemotherapy and radical hysterectomy with bilateral pelvic lymph node dissection were randomized to receive 300mL of an oral carbohydrate liquid supplement 2 hour before surgery(CHO group) or to fast on standard hospital protocol (8 hour fasting for solid and 4 hour fasting for clear liquid)(FAST group).According to inclusion and exclusion standards, twenty-six patients undergoing the same surgery and standard fasting were selected as control group. Baseline and postoperative measurements of insulin sensitivity were assessed in term of fasting plasma glucose(FPG),fastingainsulin(FINS),HOMA-insulinaresistance(HOMA-IR),HOMA-insulin secretion function index(HOMA-IX) , HOMA-beta cell function index(HOMA-β),serum C-peptide and glucagon.Baseline and postoperative measurements of tumor immunity were evaluated using NK cell and T-cell dynamics.VAS score was introduced to assess preoperative comfort.

Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period

Effects of Drug or Drink Intervention and Temperature Protectionon for Cervical Cancer Patients on Insulin Resistance and Tumor Immunity

The patient's insulin resistance was determined by fasting plasma glucose(FPG),fastingainsulin(FINS), andHOMA-IR=FPG（mmol/L）×FINS（mIU/L）/22.5

The patient's tumor immune level was determined by changes in T cells (CD3+、CD4+、CD8+、CD44+) and NK cells in the patient's blood

Fujian Cancer Hospital

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Leukemia

Graft vs Host Disease

Neoplasms by Histologic Type

Hematologic Diseases

Homologous Wasting Disease

Acute Graft Versus Host Disease

Dermatologic Agents

Methoxsalen

Furocoumarins

Photosensitizing Agents

Oral 8-Methoxypsoralene (8-MOP), (0.4-0.8 mg/kg), are given 1.5-2 hours before phototherapy. Ultraviolet light type A (UVA, 320-400 nm) is administered in a Waldmann UV1000 supine unit through 26 100-W fluorescent PUVA lamps (Waldmann F85), if needed, UVA is given in a half body unit with 15 100-W PUVA-lamps (Waldmann F85), (Waldmann UV3003K), (Waldmann, Villingen-Schwenningen, Germany). Eye protection is applied during 24 h after oral 8-MOP and the genital area are shielded in males during therapy.The UVA is initiated at 0.2-1.5 J/cm2 and is amplified by 0.25-0.5 J/cm2 after two treatments if photo toxicity is absent. PUVA is given to the patients 3-5 times each week.

Photochemotherapy

Nicolas Feldreich, M.D.

Olle Ringden, Professor

Brigitta Omazic, PhD

Cure of leukemia after hematopoietic stem cell transplantation (HSCT) is sustained by the anti-leukemic effect of the grafted cells (graft-versus-leukemia (GVL)). However, it is not known whether the tumor-immunity is affected by photochemotherapy (psoralene photosensitization and ultraviolet light radiation) administered to attenuate graft-versus host disease (GVHD).

The present study aim to investigate what happens to the GVL after photochemotherapy of aGVHD in a predominantly retrospective setting with 10-years follow-up after HSCT

This is a 10-year follow-up of patients with Acute-myeloid-leukemia (AML) or acute-lymphatic-leukemia (ALL). AML is diagnosed by the French-American-British criteria (FAB-criteria) and ALL is separated into chief forms by immunohistological methods. All patients underwent myeloablative Hematopoietic Stem Cell Transplantation (HSCT) between 1985 and 2005 at the center for allogeneic stem cell transplantation (CAST) at Karolinska University Hospital. All patient receive GVHD-prophylaxis.

The risk for relapse after HSCT is graded into low-risk if the disease is in first complete remission before HSCT, all other disease states are classified as high-risk.

Eligible patients received photochemotherapy (Ultraviolet radiation type A on skin photosensitized by oral 8-methoxypsoralen) for acute graft-versus-host disease (GVHD within 100-days after HSCT). Photochemotherapy may be given as primary or later aGVHD therapy. Patients with aGVHD after booster doses of stem-cells or donor-lymphocyte-infusions are not included.

Additional treatment are registered where present. Methotrexate is not considered as an additional GVHD treatment as intravenous methotrexate a part of the governing GVHD prophylaxis and as the effects of methotrexate as a secondary aGVHD treatment is weak.

At the start, the end, at maximum and up until two weeks after end of PUVA-therapy the GVHD is diagnosed in accordance with Glucksberg and indexed by CIBMTR.

Relapse is diagnosed when leukemic cells is present extra medullary or with a bone marrow biopsy with ≥ 30% blasts. Early relapse is diagnosed when the medulla contain 5 - 30% blasts

The primary outcome is GVL i.e. abscence of relapse in malignant disease or minimal residual disease (MRD) i.e. threatening relapse in malignant disease demanding donor lymphocyte infusion (DLI).

Primary predictor: Time-to-treatment by photochemotherapy at day 0 - 7 vs. start at day 8 ≤ of aGVHD.

Continuous secondary predictor: Time-to-treatment by photochemotherapy as a continuous variable (days after start of aGVHD).

Binary secondary predictors: Risk (Low/High), Sibling donor-recipient (Yes/No), Mismatched related (Yes/No), Unrelated donor (Yes/No), (Male recipients of female grafts (Yes/No), T-cell depletion or Anti-Thymocyte Globulin (Yes/No).

Categorical secondary predictors: AGVHD organ disease stage and disease grade; Skin (+, ++, +++, ++++), Liver (+, ++, +++, ++++), Gastro-intestinal (+, ++, +++, ++++), Center for International Blood and Marrow Transplant Research CIBMTR index (A, B, C, D) respectively.

Statistical analysis:

Cox proportional Hazards ratio is used to conduct a univariate data analysis of all adequate variables in patient characteristics and disease towards the primary outcome. In the analysis, death, DLI or retransplantation due to graft-failure was treated as a competing event. The primary predictor (binary) and all binary or categorical covariates identified from the patient and disease characteristics are to be included in a multivariate forward regression analysis, controlled for with backward regression based on the log-likelihood method. P=0.05 is considered as significant and p=0.10 as a trend. StatSoft, Inc. (2013). STATISTICA (data analysis software system), version 12. www.statsoft.com. are used for statistical computation.

Photochemotherapy and Graft-versus-leukemia in Acute-leukemia

Photochemotherapy of Acute Graft-versus-host Disease (aGVHD) of the Skin - is Graft-versus-leukemia Preserved in Patients Transplanted for Acute Leukemia?

i.e. abscence of relapse in malignant disease or minimal residual disease (MRD) i.e. threatening relapse in malignant disease demanding donor lymphocyte infusion (DLI).

Karolinska University Hospital

M.D.

Gastrointestinal Neoplasms

Digestive System Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Microbial composition using Probiotic，3 capsules / times, 2 times / day for 4 weeks

Microbiota modulation using placebo，3 capsules / times, 2 times / day for 4 weeks

Probiotic

placebo（for probiotic）

Ming Li, MD

Yang Tian, MD

Yanqing Li, MD.PhD

Probiotics modulate the gut microflora and immune status in CRC,which can reduce the side effects of chemotherapy such as diarrhea,infection,neutropenia etc.

Chemotherapy destroys the intestinal mucosal barrier, affects intestinal flora, causing bacterial translocation, infection and other complications; Probiotics may restore the intestinal immunity, mucosal barrier, and nutrient absorption.The adverse effects of chemotherapy and the malnutrition status may be relieved via probiotic administration.

Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy

Effects of Gut Microflora on the Immune and Nutritional Status of CRC Patients After Chemotherapy

Primary coordination of fecal samples' 16s rDNA (ribosomal DNA) will be compared between two Groups using Braycurtis distance based Primary coordination analysis (PCoA).

The total concentration of Short-chain fatty acids in the in feces of patients after chemotherapy.

Adverse effects includes vomiting, nausea, diarrhea and abdominal pain.

Immune status indexes include percentage of Neutrophils, total lymphocytes, lymphocyte subgroups, plasma immunoglobulin level, CRP (C reactive protein).

Nutritional status indexes include BMI, percentage of body weight changes, plasma albumin and prealbumin.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
RFA Plus Carrizumab vs Carrizumab Alone for HCC	NCT04150744	Tumor Immunity Immunosuppressi... Radiofrequency ...	radiofrequency ...	18 Years - 75 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
Intestinal Microflora in Lung Cancer After Chemotherapy	NCT02771470	Lung Cancer Effects of Chem... Tumor Immunity Malnutrition	Probiotics placebo	18 Years - 80 Years	Shandong University
RFA Plus Carrizumab vs Carrizumab Alone for HCC	NCT04150744	Tumor Immunity Immunosuppressi... Radiofrequency ...	radiofrequency ...	18 Years - 75 Years	Second Affiliated Hospital, School of Medicine, Zhejiang University
Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period	NCT03872635	Anesthesia Cervical Cancer Carbohydrate Tumor Immunity	oral carbohydra...	18 Years - 70 Years	Fujian Cancer Hospital
Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period	NCT03872635	Anesthesia Cervical Cancer Carbohydrate Tumor Immunity	oral carbohydra...	18 Years - 70 Years	Fujian Cancer Hospital
Photochemotherapy and Graft-versus-leukemia in Acute-leukemia	NCT02631993	ALL AML Acute GVHD Tumor Immunity	Photochemothera...	-	Karolinska University Hospital
Photochemotherapy and Graft-versus-leukemia in Acute-leukemia	NCT02631993	ALL AML Acute GVHD Tumor Immunity	Photochemothera...	-	Karolinska University Hospital
Intestinal Microflora in Lung Cancer After Chemotherapy	NCT02771470	Lung Cancer Effects of Chem... Tumor Immunity Malnutrition	Probiotics placebo	18 Years - 80 Years	Shandong University
Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy	NCT02169388	Gastrointestina... Colorectal Canc... Effects of Chem... Tumor Immunity Malnutrition	Probiotic placebo（for pro...	18 Years - 80 Years	Shandong University

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