Symptoms and General Pathology

All Conditions

Gland and Hormone Related Diseases

Neoplasms

Nervous System Diseases

Rare Diseases

Syndrome

Cushing Syndrome

ACTH-Secreting Pituitary Adenoma

Pituitary ACTH Hypersecretion

Adenoma

Pituitary Diseases

Adrenocortical Hyperfunction

Adrenal Gland Diseases

Endocrine System Diseases

Hypothalamic Diseases

Brain Diseases

Central Nervous System Diseases

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Pituitary Neoplasms

Endocrine Gland Neoplasms

Cushing's Syndrome

ACTH-secreting Pituitary Adenoma

Hyperadrenalism

Vasoconstrictor Agents

Central Nervous System Depressants

All Drugs and Chemicals

Cocaine

Cushing's QoL is a validated disease specific questionnaire consisting of 12 questions on a five-point Likert scale ranging from always to never. The total score ranges from 12 to 60, with a lower score indicating a greater negative impact on health related QoL. This is converted to a 0-100 scale, 0 indicating the worst and 100 indicating the best QoL

Cushing's QoL (Quality of Life Questionnaire)

NHP is used in patients to assess general health and quality of life. This assessment consists of 38 yes/no questions that are subdivided into six scales assessing impairments: pain (eight items), energy level (three items), sleep (five items), emotional reactions (nine items), social isolation (five items) and physical mobility (eight items). A higher score indicates more impairment

Nottingham Health Profile (NHP)

HADS consists of 14 items pertaining to anxiety and depression, with each item measured on a four-point scale. Total scores for the anxiety and depression subscales range from 0 to 21. A higher score indicates greater symptomatology

Hospital Anxiety and Depression Scale (HADS)

The PSS predicts both objective biological markers of stress and increased risk of disease in patients with higher stress levels.

Perceived Stress Scale (PSS)

BDI and BIS in combination have demonstrated that depression and/or binge eating may be mediating factors for the outcome of obesity

Barratt's Impulsivity Scale (BIS)

Beck Depression Inventory (BDI)

The STAI provides data to help distinguish between anxiety and depression.

State-Trait Anxiety Inventory (STAI)

The FCQ-S consists of 15 items assessing: desire to eat, anticipation of positive reinforcement from eating, anticipation of negative reinforcement (reduction of negative affect) from eating, lack of control over eating, and (physiological) hunger; higher scores reflect stronger food craving. Participants respond, using a Likert-type scale, how much each item is true of them right now.

State Food Craving Questionnaire-State (FCQ-S)

Trait food craving will be assessed with the Food Craving Questionnaire-Trait (FCQ-T). The FCQ-T consists of 39 items assessing: intentions/plans to eat, anticipation of positive reinforcement from eating, anticipation of negative reinforcement from eating, lack of control over eating, preoccupation with food, (physiological) hunger, emotions preceding or following food cravings or eating, environmental cues that may elicit food cravings, negative emotions including guilt experienced as a consequence of food cravings, and/or indulging such cravings; higher scores again indicate higher trait craving. Individuals are asked to respond, using a Likert-type scale, how much each item is true of them in general.

Trait Food Craving Questionnaire-Trait (FCQ-T)

A validated visual analogue scale (VAS) questionnaire will be completed in the fasting state. The VAS consists of 100-mm lines with words anchored at each end describing extreme sensations of hunger, prospective consumption ("How much do you think you can eat?"), fullness, and satisfaction, as well as craving (sweet, salty, fatty or savory). Patients will be asked to make a vertical mark across the line corresponding to their feelings. Quantification will performed by measuring the distance from the left end of the line to the mark.

Visual Analogue Scale (VAS)

A validated questionnaire that assesses perceived subjective value attributed to expected/hypothetical foods and other primary reinforcers will be administered. This variant of this questionnaire was initially developed by Dr. Goldstein to assess 'liking' and 'wanting' of expected drug rewards for patients with cocaine addiction. The current assessment uses a modified version to assess 'liking' and 'wanting' for food.

Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant

Eliza Geer, MD

Marc Cohen, MD

The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.

Collecting Information About Treatment Results for Patients With Cushing's Syndrome

Treatment Outcomes for Patients With Cushing's Syndrome: a Prospective Data Collection Study

Memorial Sloan Kettering Cancer Center

Digestive System Diseases

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Psychological and quality of life questionnaires

Questionnaires administration

FFMQ is a 39-item measure consisting of five subscales (observing, describing, acting with awareness, non-judging of inner experience, and non-reactivity to inner experience).

Five Facet Mindfulness Questionnaire (FFMQ)

The LMS Tis a 21-item questionnaire, assessing four domains associated with mindful thinking: novelty-seeking, engagement, novelty producing, and flexibility.

Langer Mindfulness Scale (LMS)

The CFS is 12-item self-report test assessing awareness.

Cognitive Flexibility Scale (CFS)

The LOT is a 10-item, self-administered scale assessing generalized expectancies for positive versus negative outcomes.

Life Orientation Test (LOT)

The MLS is a 6-item questionnaire that includes 3 factors : chance, powerful others, and internality.

Mini Locus of Control test (MLS)

The HADS is a 14-items rated on a four-point Likert scale. The questionnaire was designed to screen for the presence and severity of depression (HADS-D) and anxiety (HADS-A) in people with a physical symptomatology

The PSS is 14-item self-report tool commonly used to provide a global measure of perceived stress in daily life.

The TSA is a 20-item scale that evaluates the three components of alexithymia: difficulty to identify feelings and distinguish between feelings and bodily sensations of emotional arousal difficulty, describing feelings to others, and a cognitive style that is literal, utilitarian, and externally oriented.

Toronto Alexithymia Scale (TAS)

Annalisa Maroli, PhD

Francesca De Lucia, MD

Antonino Spinelli, MD, PhD

This is an observation pilot trial aimed to study to the association between mindfulness and other psychological factors, including both protective and risk factors, with recovery of functional ability following colorectal cancer surgery.

Preliminary evidence suggests that there are multiple variables that may influence the functional recovery following colorectal cancer surgery, some of which deal with the psychological domain. Distress and depression can negatively affect the perceptions of functional ability, while resilience and effective coping styles promote a better psychological adaptation to challenging situations. Furthermore, psychosocial prehabilitation and interventions have been proposed as a feasible and cost-effective way to positively influence the recovery after surgery in association with the Enhanced Recovery After Surgery (ERAS) protocol.

In particular, mindfulness is proved to be associated with higher quality of life in different medical conditions, including oncological patients and has been also associated with improved clinical outcomes.

The aim of the study is to investigate the association of mindfulness and other psychological predictors with functional and quality of life outcomes in patients undergoing colorectal surgery for oncological condition.

Psychological Predictors in Colorectal Cancer Surgery Recovery

Psychological Predictors of Post-surgical Recovery in Colorectal Cancer Patients: a Pilot Cohort Study

Length of stay calculated in days from the day of surgery until the day of discharge

Quality of Life will be assessed by using the European Organization for Research and Treatment of Cancer Quality of Life core Questionnaire (EORTC-QLQ-C30) and the European Organisation for Research and Treatment of Cancer Quality of life Questionnaire ColoRectal specific module (EORTC-QLQ-CR29)

Quality of Life will be assessed by using the European Organization for Research and Treatment of Cancer quality of Life core Questionnaire (EORTC-QLQ-C30) and the European Organisation for Research and Treatment of Cancer Quality of life Questionnaire ColoRectal specific module (EORTC-QLQ-CR29)

Istituto Clinico Humanitas

Behaviors and Mental Disorders

Quality of Life

Dermatologic Agents

Coal Tar

A concurrent supportive care intervention (intervention arm) Study assessments will be conducted at baseline (t0); at 3-6 weeks +/- 1 week from Day 1 of receiving investigational therapy, prior to sharing information on treatment response and before the first planned scan to evaluate extent of disease (t1); and at 8-12 weeks (the end of the 3 month total study time period) (t2).intervention arm will have at least monthly visits with a supportive care clinician

A concurrent supportive care intervention (intervention arm) Study assessments will be conducted at baseline (t0); at 3-6 weeks +/- 1 week from Day 1 of receiving investigational therapy, prior to sharing information on treatment response and before the first planned scan to evaluate extent of disease (t1); and at 8-12 weeks (the end of the 3 month total study time period) (t2).intervention arm will have at least monthly visits with a supportive care clinicianTo receive the investigational cancer treatment alone (control arm) no monthly visit with a supportive care clinician.

Study assessments will be conducted at baseline (t0); at 3-6 weeks +/- 1 week from Day 1 of receiving investigational therapy, prior to sharing information on treatment response and before the first planned scan to evaluate extent of disease (t1); and at 8-12 weeks (the end of the 3 month total study time period) (t2).

Expectations Survey (CanCORS)

Values Survey (Serious Illness Care Program)

Functional Assessment of Cancer Therapy-General (FACT-G)

NCCN Distress Thermometer

Quality of Communication (QOC)

Monthly visits with a supportive care clinician

visits with a supportive care clinician

Andrew Epstein, MD

This study will test whether adding personalized supportive care to medical treatment on a clinical trial affects the study participants' ability and desire to discuss their symptoms, their concerns about the future, and their approach to coping with cancer. The effects of supportive care on participants' responses to questions about these topics will be compared with those of other study participants who are being treated for cancer in a clinical trial, but are not receiving personalized supportive care.

Investigating the Impact of Proactive Palliative Care

Evaluating the Impact of Proactive Palliative Care in Patients Initiating Phase I Targeted or Immune-Based Cancer Therapeutics: A Randomized Controlled Trial

using the CanCORS Expectations Survey, which will assess, on a 4-point Likert-type scale, patients' expectations for therapeutic benefit after talking with their doctors about their experimental drug

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Collecting Information About Treatment Results for Patients With Cushing's Syndrome	NCT03364803	Cushing's Disea... Cushing Syndrom... Cushing Disease	Cushing's QoL (... Nottingham Heal... Hospital Anxiet... Perceived Stres... Barratt's Impul... Beck Depression... State-Trait Anx... State Food Crav... Trait Food Crav... Visual Analogue... Sensitivity to ...	14 Years -	Memorial Sloan Kettering Cancer Center
Psychological Predictors in Colorectal Cancer Surgery Recovery	NCT03781193	Colorectal Canc...	Questionnaires ... Five Facet Mind... Langer Mindfuln... Cognitive Flexi... Life Orientatio... Mini Locus of C... Hospital Anxiet... Perceived Stres... Toronto Alexith...	18 Years -	Istituto Clinico Humanitas
Psychological Predictors in Colorectal Cancer Surgery Recovery	NCT03781193	Colorectal Canc...	Questionnaires ... Five Facet Mind... Langer Mindfuln... Cognitive Flexi... Life Orientatio... Mini Locus of C... Hospital Anxiet... Perceived Stres... Toronto Alexith...	18 Years -	Istituto Clinico Humanitas
Investigating the Impact of Proactive Palliative Care	NCT03667378	Metastatic Soli... Locally Advance...	Expectations Su... Values Survey (... Functional Asse... NCCN Distress T... Hospital Anxiet... Quality of Comm... visits with a s...	18 Years -	Memorial Sloan Kettering Cancer Center
Collecting Information About Treatment Results for Patients With Cushing's Syndrome	NCT03364803	Cushing's Disea... Cushing Syndrom... Cushing Disease	Cushing's QoL (... Nottingham Heal... Hospital Anxiet... Perceived Stres... Barratt's Impul... Beck Depression... State-Trait Anx... State Food Crav... Trait Food Crav... Visual Analogue... Sensitivity to ...	14 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for hospital anxiety and depression scale (hads)